| Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity … MA Blaskovich, J Sun, A Cantor, J Turkson, R Jove, SM Sebti Cancer research 63 (6), 1270-1279, 2003 | 782 | 2003 |
| Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes EC Lerner, Y Qian, MA Blaskovich, RD Fossum, A Vogt, J Sun, AD Cox, ... Journal of Biological Chemistry 270 (45), 26802-26806, 1995 | 471 | 1995 |
| Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity J Sun, MA Blaskovich, R Jove, SK Livingston, D Coppola, SM Sebti Oncogene 24 (20), 3236-3245, 2005 | 346 | 2005 |
| Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human … J Sun, Y Qian, AD Hamilton, SM Sebti Oncogene 16 (11), 1467-1473, 1998 | 302 | 1998 |
| Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the … J Sun, MA Blaskovich, D Knowles, Y Qian, J Ohkanda, RD Bailey, ... Cancer research 59 (19), 4919-4926, 1999 | 294 | 1999 |
| Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion J Sun, Y Qian, AD Hamilton, SM Sebti Cancer research 55 (19), 4243-4247, 1995 | 289 | 1995 |
| Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice Z Chen, J Sun, A Pradines, G Favre, J Adnane, SM Sebti Journal of Biological Chemistry 275 (24), 17974-17978, 2000 | 269 | 2000 |
| Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis K Jiang, J Sun, J Cheng, JY Djeu, S Wei, S Sebti Molecular and cellular biology 24 (12), 5565-5576, 2004 | 237 | 2004 |
| The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21WAF1/CIP1/SDI1 in a p53-independent manner A Vogt, J Sun, Y Qian, AD Hamilton, SM Sebti Journal of Biological Chemistry 272 (43), 27224-27229, 1997 | 234 | 1997 |
| Inhibition of angiogenesis by Aβ peptides D Paris, K Townsend, A Quadros, J Humphrey, J Sun, S Brem, ... Angiogenesis 7, 75-85, 2004 | 179 | 2004 |
| GGTI-298 Induces G0-G1 Block and Apoptosis Whereas FTI-277 Causes G2-M Enrichment in A549 Cells K Miquel, A Pradines, J Sun, Y Qian, AD Hamilton, SM Sebti, G Favre Cancer research 57 (10), 1846-1850, 1997 | 172 | 1997 |
| Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice MA Blaskovich, Q Lin, FL Delarue, J Sun, HS Park, D Coppola, ... Nature biotechnology 18 (10), 1065-1070, 2000 | 171 | 2000 |
| The BH3 α-helical mimic BH3-M6 disrupts Bcl-XL, Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax-and Bim-dependent manner A Kazi, J Sun, K Doi, SS Sung, Y Takahashi, H Yin, JM Rodriguez, ... Journal of Biological Chemistry 286 (11), 9382-9392, 2011 | 163 | 2011 |
| Disruption of the Rb-Raf-1 interaction inhibits tumor growth and angiogenesis P Dasgupta, J Sun, S Wang, G Fusaro, V Betts, J Padmanabhan, ... Molecular and cellular biology 24 (21), 9527-9541, 2004 | 130 | 2004 |
| Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors J Sun, D Wang, RK Jain, A Carie, S Paquette, E Ennis, MA Blaskovich, ... Oncogene 24 (29), 4701-4709, 2005 | 128 | 2005 |
| Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins J Wei, S Kitada, MF Rega, A Emdadi, H Yuan, J Cellitti, JL Stebbins, ... Molecular cancer therapeutics 8 (4), 904-913, 2009 | 102 | 2009 |
| Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice J Sun, J Ohkanda, D Coppola, H Yin, M Kothare, B Busciglio, ... Cancer research 63 (24), 8922-8929, 2003 | 101 | 2003 |
| CEP1612, a Dipeptidyl Proteasome Inhibitor, Induces p21WAF1 and p27KIP1 Expression and Apoptosis and Inhibits the Growth of the Human Lung … J Sun, S Nam, CS Lee, B Li, D Coppola, AD Hamilton, QP Dou, SM Sebti Cancer research 61 (4), 1280-1284, 2001 | 101 | 2001 |
| Bcl-XL-Templated Assembly of Its Own Protein−Protein Interaction Modulator from Fragments Decorated with Thio Acids and Sulfonyl Azides X Hu, J Sun, HG Wang, R Manetsch Journal of the American Chemical Society 130 (42), 13820-13821, 2008 | 95 | 2008 |
| Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor J Sun, MA Blaskovich, RK Jain, F Delarue, D Paris, S Brem, ... Cancer research 64 (10), 3586-3592, 2004 | 92 | 2004 |