| Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics CJ Markin, DA Mokhtari, F Sunden, MJ Appel, E Akiva, SA Longwell, ... Science 373 (6553), eabf8761, 2021 | 163 | 2021 |
| Covalent inhibition of Ubc13 affects ubiquitin signaling and reveals active site elements important for targeting CD Hodge, RA Edwards, CJ Markin, D McDonald, M Pulvino, MSY Huen, ... ACS chemical biology 10 (7), 1718-1728, 2015 | 70 | 2015 |
| An open-source, programmable pneumatic setup for operation and automated control of single-and multi-layer microfluidic devices K Brower, RR Puccinelli, CJ Markin, TC Shimko, SA Longwell, B Cruz, ... HardwareX 3, 117-134, 2018 | 55 | 2018 |
| Increased precision for analysis of protein–ligand dissociation constants determined from chemical shift titrations CJ Markin, L Spyracopoulos Journal of biomolecular NMR 53, 125-138, 2012 | 39 | 2012 |
| High-throughput affinity measurements of transcription factor and DNA mutations reveal affinity and specificity determinants AK Aditham, CJ Markin, DA Mokhtari, N DelRosso, PM Fordyce Cell Systems 12 (2), 112-127. e11, 2021 | 36 | 2021 |
| Mechanism for recognition of polyubiquitin chains: balancing affinity through interplay between multivalent binding and dynamics CJ Markin, W Xiao, L Spyracopoulos Journal of the American Chemical Society 132 (32), 11247-11258, 2010 | 33 | 2010 |
| Catalytic Proficiency of Ubiquitin Conjugation Enzymes: Balancing pKa Suppression, Entropy, and Electrostatics CJ Markin, LF Saltibus, MJ Kean, RT McKay, W Xiao, L Spyracopoulos Journal of the American Chemical Society 132 (50), 17775-17786, 2010 | 30 | 2010 |
| Stochastic gate dynamics regulate the catalytic activity of ubiquitination enzymes MK Rout, CD Hodge, CJ Markin, X Xu, JNM Glover, W Xiao, ... Journal of the American Chemical Society 136 (50), 17446-17458, 2014 | 23 | 2014 |
| Accuracy and precision of protein–ligand interaction kinetics determined from chemical shift titrations CJ Markin, L Spyracopoulos Journal of Biomolecular NMR 54, 355-376, 2012 | 20 | 2012 |
| Molecular basis for impaired DNA damage response function associated with the RAP80 ΔE81 defect CJ Markin, MK Rout, L Spyracopoulos Journal of Biological Chemistry 289 (18), 12852-12862, 2014 | 10 | 2014 |
| Dynamics of the RING Domain from Human TRAF6 by 15N NMR Spectroscopy: Implications for Biological Function CJ Markin, LF Saltibus, L Spyracopoulos Biochemistry 47 (38), 10010-10017, 2008 | 9 | 2008 |
| Context-dependent remodeling of structure in two large protein fragments MJ Schellenberg, DB Ritchie, T Wu, CJ Markin, L Spyracopoulos, ... Journal of molecular biology 402 (4), 720-730, 2010 | 8 | 2010 |
| Decoupling of catalysis and transition state analog binding from mutations throughout a phosphatase revealed by high-throughput enzymology CJ Markin, DA Mokhtari, S Du, T Doukov, F Sunden, JA Cook, ... Proceedings of the National Academy of Sciences 120 (29), e2219074120, 2023 | 7 | 2023 |
| Aptasensor-encapsulating semi-permeable proteinosomes for direct target detection in non-treated biofluids J Kim, H Yoo, S Woo, SS Oh Biosensors and Bioelectronics 251, 116062, 2024 | 3 | 2024 |
| Designing active and thermostable enzymes with sequence-only predictive models C Fannjiang, M Olivas, ER Greene, CJ Markin, B Wallace, B Krause, ... NeurIPS 2022 Workshop on Learning Meaningful Representations of Life, 2022 | 2 | 2022 |
| High-throughput binding affinity measurements for mutations spanning a transcription factor-DNA interface reveal affinity and specificity determinants AK Aditham, CJ Markin, DA Mokhtari, NV DelRosso, PM Fordyce BioRxiv, 2020.06. 22.165571, 2020 | 2 | 2020 |
| High-throughput enzymology reveals mutations throughout a phosphatase that decouple catalysis and transition state analog affinity CJ Markin, DA Mokhtari, S Du, T Doukov, F Sunden, PM Fordyce, ... bioRxiv, 2022.11. 07.515533, 2022 | 1 | 2022 |
| Leveraging Microfluidics for High‐Throughput Studies of Transcription Factor/DNA Binding P Fordyce, A Aditham, C Horton, N DelRosso, D Mokhtari, C Markin The FASEB Journal 34 (S1), 1-1, 2020 | 1 | 2020 |
| Kinetic Data: Urea, Zinc, and pH Titrations CJ Markin, DA Mokhtari OSF, 2021 | | 2021 |
| Structural Representations CJ Markin, DA Mokhtari OSF, 2021 | | 2021 |
Leo SpyracopoulosDepartment of Biochemistry, University of AlbertaPotvrđena adresa e-pošte na ualberta.ca