Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer’s disease S Lee, X Zheng, J Krishnamoorthy, MG Savelieff, HM Park, JR Brender, ... Journal of the American Chemical Society 136 (1), 299-310, 2014 | 208 | 2014 |
Resolution of Oligomeric Species during the Aggregation of Aβ1–40 Using 19F NMR Y Suzuki, JR Brender, MT Soper, J Krishnamoorthy, Y Zhou, BT Ruotolo, ... Biochemistry 52 (11), 1903-1912, 2013 | 125 | 2013 |
Indolicidin targets duplex DNA: structural and mechanistic insight through a combination of spectroscopy and microscopy A Ghosh, RK Kar, J Jana, A Saha, B Jana, J Krishnamoorthy, D Kumar, ... ChemMedChem 9 (9), 2052-2058, 2014 | 118 | 2014 |
High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification SA Kotler, JR Brender, S Vivekanandan, Y Suzuki, K Yamamoto, ... Scientific reports 5 (1), 11811, 2015 | 117 | 2015 |
Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at … JR Brender, J Krishnamoorthy, MFM Sciacca, S Vivekanandan, L D’Urso, ... The journal of physical chemistry B 119 (7), 2886-2896, 2015 | 105 | 2015 |
Lipopolysaccharide from gut microbiota modulates α-synuclein aggregation and alters its biological function D Bhattacharyya, GM Mohite, J Krishnamoorthy, N Gayen, S Mehra, ... ACS chemical neuroscience 10 (5), 2229-2236, 2019 | 104 | 2019 |
Lipid composition-dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78) DK Lee, JR Brender, MFM Sciacca, J Krishnamoorthy, C Yu, ... Biochemistry 52 (19), 3254-3263, 2013 | 79 | 2013 |
Accurate machine-learning-based classification of leukemia from blood smear images K Dese, H Raj, G Ayana, T Yemane, W Adissu, J Krishnamoorthy, T Kwa Clinical Lymphoma Myeloma and Leukemia 21 (11), e903-e914, 2021 | 78 | 2021 |
Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide JR Brender, J Krishnamoorthy, GML Messina, A Deb, S Vivekanandan, ... Chemical Communications 49 (32), 3339-3341, 2013 | 78 | 2013 |
Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1 PH Bernardo, T Sivaraman, KF Wan, J Xu, J Krishnamoorthy, CM Song, ... Journal of medicinal chemistry 53 (5), 2314-2318, 2010 | 62 | 2010 |
Inhibition and degradation of amyloid beta (Aβ40) fibrillation by designed small peptide: A combined spectroscopy, microscopy, and cell toxicity study A Ghosh, N Pradhan, S Bera, A Datta, J Krishnamoorthy, NR Jana, ... ACS chemical neuroscience 8 (4), 718-722, 2017 | 53 | 2017 |
Probing transient non-native states in amyloid beta fiber elongation by NMR JR Brender, A Ghosh, SA Kotler, J Krishnamoorthy, S Bera, V Morris, ... Chemical Communications 55 (31), 4483-4486, 2019 | 52 | 2019 |
Synthetic flavonoids, aminoisoflavones: interaction and reactivity with metal-free and metal-associated amyloid-β species AS DeToma, J Krishnamoorthy, Y Nam, HJ Lee, JR Brender, A Kochi, ... Chemical science (Royal Society of Chemistry: 2010) 5 (12), 4851, 2014 | 40 | 2014 |
Auto-FACE: an NMR based binding site mapping program for fast chemical exchange protein-ligand systems J Krishnamoorthy, VCK Yu, YK Mok PloS one 5 (2), e8943, 2010 | 34 | 2010 |
Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1 PH Bernardo, T Sivaraman, KF Wan, J Xu, J Krishnamoorthy, CM Song, ... Pure and Applied Chemistry 83 (3), 723-731, 2011 | 31 | 2011 |
Comparison of synthetic neuronal model membrane mimics in amyloid aggregation at atomic resolution S Bera, N Gayen, SA Mohid, D Bhattacharyya, J Krishnamoorthy, ... ACS Chemical Neuroscience 11 (13), 1965-1977, 2020 | 25 | 2020 |
Side-Chain Dynamics Reveals Transient Association of Aβ1–40 Monomers with Amyloid Fibers J Krishnamoorthy, JR Brender, S Vivekanandan, N Jahr, A Ramamoorthy The Journal of Physical Chemistry B 116 (46), 13618-13623, 2012 | 25 | 2012 |
De-speckling breast cancer ultrasound images using a rotationally invariant block matching based non-local means (RIBM-NLM) method G Ayana, K Dese, H Raj, J Krishnamoorthy, T Kwa Diagnostics 12 (4), 862, 2022 | 18 | 2022 |
Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: A high-resolution NMR study R Yesuvadian, J Krishnamoorthy, A Ramamoorthy, A Bhunia Biochemical and Biophysical Research Communications 447 (4), 590-595, 2014 | 18 | 2014 |
Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-β AS DeToma, J Krishnamoorthy, Y Nam, HJ Lee, JR Brender, A Kochi, ... Chemical Science 5 (12), 4851-4862, 2014 | 18 | 2014 |