Metabolic and Vascular Imaging Biomarkers for Brain Aging and Alzheimer’s Disease AL Lin, A Gjedde, H Fahmeed Frontiers in Aging Neuroscience, 2020 | 1183* | 2020 |
Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice D Ma, AC Wang, I Parikh, SJ Green, JD Hoffman, G Chlipala, MP Murphy, ... Scientific reports 8 (1), 1-10, 2018 | 318 | 2018 |
Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex AL Lin, PT Fox, J Hardies, TQ Duong, JH Gao Proceedings of the National Academy of Sciences 107 (18), 8446-8451, 2010 | 269 | 2010 |
Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease AL Lin, W Zheng, JJ Halloran, RR Burbank, SA Hussong, MJ Hart, ... Journal of Cerebral Blood Flow & Metabolism 33 (9), 1412-1421, 2013 | 227 | 2013 |
Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease AL Lin, JB Jahrling, W Zhang, N DeRosa, V Bakshi, P Romero, V Galvan, ... Journal of Cerebral Blood Flow & Metabolism 37 (1), 217-226, 2017 | 153 | 2017 |
Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model JD Hoffman, LM Yanckello, G Chlipala, TC Hammond, SD McCulloch, ... PloS one 14 (8), e0221828, 2019 | 142 | 2019 |
How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story A Richardson, V Galvan, AL Lin, S Oddo Experimental gerontology 68, 51-58, 2015 | 134 | 2015 |
Age drives distortion of brain metabolic, vascular and cognitive functions, and the gut microbiome JD Hoffman, I Parikh, SJ Green, G Chlipala, RP Mohney, M Keaton, ... Frontiers in Aging Neuroscience 9, 298, 2017 | 121 | 2017 |
Complex IV-deficient Surf1-/- mice initiate mitochondrial stress responses P DA, D SS, L Y, H S, L AL, B A, S Y, S L, V C, Z M, V Remmen H. Biochem J 462 (2), 359-371, 2014 | 118 | 2014 |
Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals ET Ighodaro, EL Abner, DW Fardo, AL Lin, Y Katsumata, FA Schmitt, ... Journal of Cerebral Blood Flow & Metabolism 37 (1), 201-216, 2017 | 107 | 2017 |
Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF AL Lin, PT Fox, Y Yang, H Lu, LH Tan, JH Gao Magnetic Resonance in Medicine: An Official Journal of the International …, 2008 | 107 | 2008 |
β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline TC Hammond, X Xing, C Wang, D Ma, K Nho, PK Crane, F Elahi, ... Communications biology 3 (1), 352, 2020 | 106 | 2020 |
Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain AL Lin, W Zhang, X Gao, L Watts Neurobiology of aging 36 (7), 2296-2303, 2015 | 102 | 2015 |
Multimodal bioimaging using a rare earth doped Gd 2 O 2 S: Yb/Er phosphor with upconversion luminescence and magnetic resonance properties G Ajithkumar, B Yoo, DE Goral, PJ Hornsby, AL Lin, U Ladiwala, ... Journal of Materials Chemistry B 1 (11), 1561-1572, 2013 | 100 | 2013 |
Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions I Parikh, J Guo, KH Chuang, Y Zhong, RG Rempe, JD Hoffman, ... Aging (Albany NY) 8 (11), 2814, 2016 | 98 | 2016 |
Methylene blue as a cerebral metabolic and hemodynamic enhancer AL Lin, E Poteet, F Du, RC Gourav, R Liu, Y Wen, A Bresnen, S Huang, ... Public Library of Science 7 (10), e46585, 2012 | 88 | 2012 |
Early shifts of brain metabolism by caloric restriction preserve white matter integrity and long-term memory in aging mice J Guo, V Bakshi, AL Lin Frontiers in aging neuroscience 7, 213, 2015 | 74 | 2015 |
mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging CE Van Skike, AL Lin, R Roberts Burbank, JJ Halloran, SF Hernandez, ... Aging Cell 19 (1), e13057, 2020 | 70 | 2020 |
Bimodal imaging using neodymium doped gadolinium fluoride nanocrystals with nearinfrared to nearinfrared downconversion luminescence and magnetic resonance properties M CL, A G, P M, Y BG, E ZG, P F, D A, T L, L AL, D VP, S DK J. Mater. Chem. B., 2013 | 65 | 2013 |
Blood longitudinal (T 1) and transverse (T 2) relaxation time constants at 11.7 Tesla AL Lin, Q Qin, X Zhao, TQ Duong Magnetic Resonance Materials in Physics, Biology and Medicine 25, 245-249, 2012 | 63 | 2012 |