| Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers IB Hilton, AM D'ippolito, CM Vockley, PI Thakore, GE Crawford, TE Reddy, ... Nature biotechnology 33 (5), 510-517, 2015 | 2212 | 2015 |
| RNA-guided gene activation by CRISPR-Cas9–based transcription factors P Perez-Pinera, DD Kocak, CM Vockley, AF Adler, AM Kabadi, ... Nature methods 10 (10), 973-976, 2013 | 1732 | 2013 |
| In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy CE Nelson, CH Hakim, DG Ousterout, PI Thakore, EA Moreb, RMC Rivera, ... Science 351 (6271), 403-407, 2016 | 1381 | 2016 |
| Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements PI Thakore, AM D'ippolito, L Song, A Safi, NK Shivakumar, AM Kabadi, ... Nature methods 12 (12), 1143-1149, 2015 | 1067 | 2015 |
| Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy DG Ousterout, AM Kabadi, PI Thakore, WH Majoros, TE Reddy, ... Nature communications 6 (1), 6244, 2015 | 555 | 2015 |
| Editing the epigenome: technologies for programmable transcription and epigenetic modulation PI Thakore, JB Black, IB Hilton, CA Gersbach Nature methods 13 (2), 127-137, 2016 | 527 | 2016 |
| Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells EP Mimitou, CA Lareau, KY Chen, AL Zorzetto-Fernandes, Y Hao, ... Nature biotechnology 39 (10), 1246-1258, 2021 | 372 | 2021 |
| Cycling cancer persister cells arise from lineages with distinct programs Y Oren, M Tsabar, MS Cuoco, L Amir-Zilberstein, HF Cabanos, JC Hütter, ... Nature 596 (7873), 576-582, 2021 | 348 | 2021 |
| Metabolic modeling of single Th17 cells reveals regulators of autoimmunity A Wagner, C Wang, J Fessler, D DeTomaso, J Avila-Pacheco, J Kaminski, ... Cell 184 (16), 4168-4185. e21, 2021 | 339 | 2021 |
| Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients DG Ousterout, P Perez-Pinera, PI Thakore, AM Kabadi, MT Brown, X Qin, ... Molecular Therapy 21 (9), 1718-1726, 2013 | 232 | 2013 |
| Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion CJ Frangieh, JC Melms, PI Thakore, KR Geiger-Schuller, P Ho, ... Nature genetics 53 (3), 332-341, 2021 | 198 | 2021 |
| Calcitonin gene-related peptide negatively regulates alarmin-driven type 2 innate lymphoid cell responses A Wallrapp, PR Burkett, SJ Riesenfeld, SJ Kim, E Christian, ... Immunity 51 (4), 709-723. e6, 2019 | 197 | 2019 |
| RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors PI Thakore, JB Kwon, CE Nelson, DC Rouse, MP Gemberling, ML Oliver, ... Nature communications 9 (1), 1674, 2018 | 173 | 2018 |
| Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity A Schnell, L Huang, M Singer, A Singaraju, RM Barilla, BML Regan, ... Cell 184 (26), 6281-6298. e23, 2021 | 171 | 2021 |
| Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes E Kiner, E Willie, B Vijaykumar, K Chowdhary, H Schmutz, J Chandler, ... Nature immunology 22 (2), 216-228, 2021 | 170 | 2021 |
| Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases DG Ousterout, AM Kabadi, PI Thakore, P Perez-Pinera, MT Brown, ... Molecular Therapy 23 (3), 523-532, 2015 | 141 | 2015 |
| RNA-guided gene editing and gene regulation CA Gersbach, IB Hilton, P Perez-Pinera, AM Kabadi, PI Thakore, ... US Patent 10,704,060, 2020 | 140 | 2020 |
| CRISPR-based epigenome editing of cytokine receptors for the promotion of cell survival and tissue deposition in inflammatory environments N Farhang, JM Brunger, JD Stover, PI Thakore, B Lawrence, F Guilak, ... Tissue Engineering Part A 23 (15-16), 738-749, 2017 | 99 | 2017 |
| Massively parallel phenotyping of coding variants in cancer with Perturb-seq O Ursu, JT Neal, E Shea, PI Thakore, L Jerby-Arnon, L Nguyen, D Dionne, ... Nature biotechnology 40 (6), 896-905, 2022 | 87 | 2022 |
| Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function D He, H Xu, H Zhang, R Tang, Y Lan, R Xing, S Li, E Christian, Y Hou, ... Immunity 55 (1), 159-173. e9, 2022 | 86 | 2022 |