Preclinical mouse solid tumour models: status quo, challenges and perspectives N Gengenbacher, M Singhal, HG Augustin Nature Reviews Cancer 17 (12), 751-765, 2017 | 340 | 2017 |
Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence MR Garcia, B Steinbauer, K Srivastava, M Singhal, F Mattijssen, A Maida, ... Cell metabolism 26 (6), 842-855. e5, 2017 | 257 | 2017 |
Endothelial Tie1–mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis S La Porta, L Roth, M Singhal, C Mogler, C Spegg, B Schieb, X Qu, ... The Journal of clinical investigation 128 (2), 834-845, 2018 | 101 | 2018 |
STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis Y Shen, X Wang, Y Liu, M Singhal, C Gürkaşlar, AF Valls, Y Lei, W Hu, ... Science Signaling 14 (712), eabj8393, 2021 | 82 | 2021 |
Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis S Jagadeeshan, YR Krishnamoorthy, M Singhal, A Subramanian, ... Oncogene 34 (4), 455-464, 2015 | 65 | 2015 |
Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis M Singhal, N Gengenbacher, AA Abdul Pari, M Kamiyama, L Hai, ... Science translational medicine 13 (609), eabe6805, 2021 | 50 | 2021 |
P21-activated kinase 1 (Pak1) signaling influences therapeutic outcome in pancreatic cancer S Jagadeeshan, A Subramanian, S Tentu, S Beesetti, M Singhal, ... Annals of oncology 27 (8), 1546-1556, 2016 | 46 | 2016 |
LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency MN O’Connor, DM Kallenberg, C Camilli, C Pilotti, A Dritsoula, ... Med 2 (11), 1231-1252. e10, 2021 | 40 | 2021 |
Endothelial cell fitness dictates the source of regenerating liver vasculature M Singhal, X Liu, D Inverso, K Jiang, J Dai, H He, S Bartels, W Li, ... Journal of Experimental Medicine 215 (10), 2497-2508, 2018 | 40 | 2018 |
Beyond angiogenesis: exploiting angiocrine factors to restrict tumor progression and metastasis M Singhal, HG Augustin Cancer research 80 (4), 659-662, 2020 | 36 | 2020 |
Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma AA Abdul Pari, M Singhal, C Huebers, C Mogler, B Schieb, A Gampp, ... Cancer research 80 (12), 2586-2598, 2020 | 32 | 2020 |
Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization MA Karreman, AT Bauer, G Solecki, AS Berghoff, CD Mayer, K Frey, ... Cancer research 83 (8), 1299-1314, 2023 | 30 | 2023 |
Timed Ang2-targeted therapy identifies the angiopoietin–tie pathway as key regulator of fatal lymphogenous metastasis N Gengenbacher, M Singhal, C Mogler, L Hai, L Milde, AAA Pari, ... Cancer discovery 11 (2), 424-445, 2021 | 30 | 2021 |
Primary tumor–derived systemic nANGPTL4 inhibits metastasis C Hübers, AA Abdul Pari, D Grieshober, M Petkov, A Schmidt, T Messmer, ... Journal of Experimental Medicine 220 (1), e20202595, 2022 | 28 | 2022 |
Emerging paradigms in metastasis research AA Abdul Pari, M Singhal, HG Augustin Journal of Experimental Medicine 218 (1), e20190218, 2020 | 26 | 2020 |
Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody M Singhal, N Gengenbacher, S La Porta, S Gehrs, J Shi, M Kamiyama, ... EMBO Molecular Medicine 12 (6), e11164, 2020 | 23 | 2020 |
Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions A Kumar, M Singhal, C Chopra, S Srinivasan, RP Surabhi, R Kanumuri, ... Oncogene 35 (37), 4857-4865, 2016 | 15 | 2016 |
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice N Tisch, C Mogler, A Stojanovic, R Luck, EA Korhonen, A Ellerkmann, ... EMBO Molecular Medicine 14 (6), e14121, 2022 | 13 | 2022 |
Molecular mechanism of regulation of MTA1 expression by granulocyte colony-stimulating factor AS Kumar, S Jagadeeshan, A Subramanian, SB Chidambaram, ... Journal of Biological Chemistry 291 (23), 12310-12321, 2016 | 13 | 2016 |
Sphingosine-1-phosphate recruits macrophages and microglia and induces a pro-tumorigenic phenotype that favors glioma progression L Arseni, R Sharma, N Mack, D Nagalla, S Ohl, T Hielscher, M Singhal, ... Cancers 15 (2), 479, 2023 | 11 | 2023 |