| Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations Y Cho, S Gorina, PD Jeffrey, NP Pavletich Science 265 (5170), 346-355, 1994 | 3356 | 1994 |
| Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex PD Jeffrey, AA Russo, K Polyak, E Gibbs, J Hurwitz, J Massagué, ... Nature 376 (6538), 313-320, 1995 | 1931 | 1995 |
| Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex N Zheng, BA Schulman, L Song, JJ Miller, PD Jeffrey, P Wang, C Chu, ... Nature 416 (6882), 703-709, 2002 | 1769 | 2002 |
| Structural basis for inhibition of the epidermal growth factor receptor by cetuximab S Li, KR Schmitz, PD Jeffrey, JJW Wiltzius, P Kussie, KM Ferguson Cancer cell 7 (4), 301-311, 2005 | 1385 | 2005 |
| Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex AA Russo, PD Jeffrey, AK Patten, J Massagué, NP Pavletich Nature 382 (6589), 325-331, 1996 | 1237 | 1996 |
| Structure of a c-Cbl–UbcH7 complex: RING domain function in ubiquitin-protein ligases N Zheng, P Wang, PD Jeffrey, NP Pavletich Cell 102 (4), 533-539, 2000 | 1085 | 2000 |
| Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation CR Antonescu, P Besmer, T Guo, K Arkun, G Hom, B Koryotowski, ... Clinical cancer research 11 (11), 4182-4190, 2005 | 1001 | 2005 |
| BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure H Yang, PD Jeffrey, J Miller, E Kinnucan, Y Sun, NH Thoma, N Zheng, ... Science 297 (5588), 1837-1848, 2002 | 894 | 2002 |
| Structural basis of cyclin-dependent kinase activation by phosphorylation AA Russo, PD Jeffrey, NP Pavletich Nature structural biology 3 (8), 696-700, 1996 | 847 | 1996 |
| Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms PD Jeffrey, S Gorina, NP Pavletich Science 267 (5203), 1498-1502, 1995 | 804 | 1995 |
| Structure of a β-TrCP1-Skp1-β-catenin complex: destruction motif binding and lysine specificity of the SCFβ-TrCP1 ubiquitin ligase G Wu, G Xu, BA Schulman, PD Jeffrey, JW Harper, NP Pavletich Molecular cell 11 (6), 1445-1456, 2003 | 772 | 2003 |
| Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex BA Schulman, AC Carrano, PD Jeffrey, Z Bowen, ERE Kinnucan, ... Nature 408 (6810), 381-386, 2000 | 771 | 2000 |
| Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein A Oberstein, PD Jeffrey, Y Shi Journal of Biological Chemistry 282 (17), 13123-13132, 2007 | 708 | 2007 |
| Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a AA Russo, L Tong, JO Lee, PD Jeffrey, NP Pavletich Nature 395 (6699), 237-243, 1998 | 692 | 1998 |
| Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms Y Xu, L Feng, PD Jeffrey, Y Shi, FMM Morel Nature 452 (7183), 56-61, 2008 | 657 | 2008 |
| Structure of the protein phosphatase 2A holoenzyme Y Xu, Y Xing, Y Chen, Y Chao, Z Lin, E Fan, WY Jong, S Strack, ... Cell 127 (6), 1239-1251, 2006 | 602 | 2006 |
| Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling JP Himanen, MJ Chumley, M Lackmann, C Li, WA Barton, PD Jeffrey, ... Nature neuroscience 7 (5), 501-509, 2004 | 596 | 2004 |
| BET inhibitor resistance emerges from leukaemia stem cells CY Fong, O Gilan, EYN Lam, AF Rubin, S Ftouni, D Tyler, K Stanley, ... Nature 525 (7570), 538-542, 2015 | 544 | 2015 |
| Structural basis of UV DNA-damage recognition by the DDB1–DDB2 complex A Scrima, R Koníčková, BK Czyzewski, Y Kawasaki, PD Jeffrey, ... Cell 135 (7), 1213-1223, 2008 | 506 | 2008 |
| Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14 M Hu, P Li, L Song, PD Jeffrey, TA Chernova, KD Wilkinson, RE Cohen, ... The EMBO journal 24 (21), 3747-3756, 2005 | 503 | 2005 |
