| Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor–mutant lung adenocarcinomas with acquired resistance to kinase inhibitors MN Balak, Y Gong, GJ Riely, R Somwar, AR Li, MF Zakowski, A Chiang, ... Clinical cancer research 12 (21), 6494-6501, 2006 | 998 | 2006 |
| ARN-509: a novel antiandrogen for prostate cancer treatment NJ Clegg, J Wongvipat, JD Joseph, C Tran, S Ouk, A Dilhas, Y Chen, ... Cancer research 72 (6), 1494-1503, 2012 | 804 | 2012 |
| Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90 C Schneider, L Sepp-Lorenzino, E Nimmesgern, O Ouerfelli, ... Proceedings of the National Academy of Sciences 93 (25), 14536-14541, 1996 | 522 | 1996 |
| Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer L Regales, Y Gong, R Shen, E de Stanchina, I Vivanco, A Goel, ... The Journal of clinical investigation 119 (10), 3000-3010, 2009 | 482 | 2009 |
| Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’protein N Abdul-Manan, B Aghazadeh, GA Liu, A Majumdar, O Ouerfelli, ... Nature 399 (6734), 379-383, 1999 | 439 | 1999 |
| Loss of BAP1 function leads to EZH2-dependent transformation LM LaFave, W Béguelin, R Koche, M Teater, B Spitzer, A Chramiec, ... Nature medicine 21 (11), 1344-1349, 2015 | 388 | 2015 |
| Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation JR Peterson, LC Bickford, D Morgan, AS Kim, O Ouerfelli, MW Kirschner, ... Nature structural & molecular biology 11 (8), 747-755, 2004 | 223 | 2004 |
| HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans S Marubayashi, P Koppikar, T Taldone, O Abdel-Wahab, N West, ... The Journal of clinical investigation 120 (10), 3578-3593, 2010 | 214 | 2010 |
| Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates G Ragupathi, F Koide, PO Livingston, YS Cho, A Endo, Q Wan, ... Journal of the American Chemical Society 128 (8), 2715-2725, 2006 | 202 | 2006 |
| Sequence characteristics of functional siRNAs B Jagla, N Aulner, PD Kelly, DA Song, A Volchuk, A Zatorski, D Shum, ... Rna 11 (6), 864-872, 2005 | 199 | 2005 |
| The polycomb repressor complex 1 drives double-negative prostate cancer metastasis by coordinating stemness and immune suppression W Su, HH Han, Y Wang, B Zhang, B Zhou, Y Cheng, A Rumandla, ... Cancer cell 36 (2), 139-155. e10, 2019 | 192 | 2019 |
| Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling E Petrova, J Rios-Esteves, O Ouerfelli, JF Glickman, MD Resh Nature chemical biology 9 (4), 247-249, 2013 | 188 | 2013 |
| Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines R Somwar, H Erdjument-Bromage, E Larsson, D Shum, WW Lockwood, ... Proceedings of the National Academy of Sciences 108 (39), 16375-16380, 2011 | 172 | 2011 |
| Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer PJ Sabbatini, G Ragupathi, C Hood, CA Aghajanian, M Juretzka, ... Clinical cancer research 13 (14), 4170-4177, 2007 | 168 | 2007 |
| CSF1/CSF1R signaling inhibitor pexidartinib (PLX3397) reprograms tumor-associated macrophages and stimulates T-cell infiltration in the sarcoma microenvironment T Fujiwara, MA Yakoub, A Chandler, AB Christ, G Yang, O Ouerfelli, ... Molecular cancer therapeutics 20 (8), 1388-1399, 2021 | 154 | 2021 |
| Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase LPS de Carvalho, H Zhao, CE Dickinson, NM Arango, CD Lima, ... Chemistry & biology 17 (4), 323-332, 2010 | 122 | 2010 |
| Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials B Gold, M Pingle, SJ Brickner, N Shah, J Roberts, M Rundell, WC Bracken, ... Proceedings of the National Academy of Sciences 109 (40), 16004-16011, 2012 | 121 | 2012 |
| From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine J Zhu, Q Wan, D Lee, G Yang, MK Spassova, O Ouerfelli, G Ragupathi, ... Journal of the American Chemical Society 131 (26), 9298-9303, 2009 | 119 | 2009 |
| CRISPR-Cas III-A Csm6 CARF domain is a ring nuclease triggering stepwise cA4 cleavage with ApA> p formation terminating RNase activity N Jia, R Jones, G Yang, O Ouerfelli, DJ Patel Molecular cell 75 (5), 944-956. e6, 2019 | 116 | 2019 |
| Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells J Vaubourgeix, G Lin, N Dhar, N Chenouard, X Jiang, H Botella, T Lupoli, ... Cell host & microbe 17 (2), 178-190, 2015 | 109 | 2015 |
