Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism T Farge, E Saland, F De Toni, N Aroua, M Hosseini, R Perry, C Bosc, ... Cancer discovery 7 (7), 716-735, 2017 | 807 | 2017 |
High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells L Poulain, P Sujobert, F Zylbersztejn, S Barreau, L Stuani, M Lambert, ... Leukemia 31 (11), 2326-2335, 2017 | 144 | 2017 |
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites C Bosc, N Broin, M Fanjul, E Saland, T Farge, C Courdy, A Batut, ... Nature communications 11 (1), 4056, 2020 | 142 | 2020 |
Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia S Bertoli, E Paubelle, E Bérard, E Saland, X Thomas, S Tavitian, ... European journal of haematology 102 (2), 131-142, 2019 | 99 | 2019 |
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia L Stuani, M Sabatier, E Saland, G Cognet, N Poupin, C Bosc, FA Castelli, ... Journal of Experimental Medicine 218 (5), 2021 | 91 | 2021 |
Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia C Bosc, E Saland, A Bousard, N Gadaud, M Sabatier, G Cognet, T Farge, ... Nature cancer 2 (11), 1204-1223, 2021 | 79 | 2021 |
Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia N Aroua, E Boet, M Ghisi, ML Nicolau-Travers, E Saland, R Gwilliam, ... Cancer Discovery 10 (10), 1544-1565, 2020 | 70 | 2020 |
Targeting myeloperoxidase disrupts mitochondrial redox balance and overcomes cytarabine resistance in human acute myeloid leukemia M Hosseini, HR Rezvani, N Aroua, C Bosc, T Farge, E Saland, ... Cancer Research 79 (20), 5191-5203, 2019 | 62 | 2019 |
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells C Larrue, N Guiraud, PL Mouchel, M Dubois, T Farge, M Gotanègre, ... Nature communications 12 (1), 422, 2021 | 51 | 2021 |
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia M Sabatier, R Birsen, L Lauture, S Mouche, P Angelino, J Dehairs, ... Cancer discovery 13 (7), 1720-1747, 2023 | 49 | 2023 |
CD36 drives metastasis and relapse in acute myeloid leukemia T Farge, J Nakhle, D Lagarde, G Cognet, N Polley, R Castellano, ... Cancer research 83 (17), 2824-2838, 2023 | 34 | 2023 |
Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia C Cerella, A Gaigneaux, A Mazumder, JY Lee, E Saland, F Radogna, ... Leukemia 31 (3), 755-759, 2017 | 33 | 2017 |
Mesenchymal stromal cells confer chemoresistance to myeloid leukemia blasts through Side Population functionality and ABC transporter activation L Boutin, P Arnautou, A Trignol, A Ségot, T Farge, C Desterke, S Soave, ... Haematologica 105 (4), 987, 2019 | 32 | 2019 |
Activation of vitamin D receptor pathway enhances differentiating capacity in acute myeloid leukemia with isocitrate dehydrogenase mutations M Sabatier, E Boet, S Zaghdoudi, N Guiraud, A Hucteau, N Polley, ... Cancers 13 (20), 5243, 2021 | 13 | 2021 |
Thrombospondin-1 silencing improves lymphocyte infiltration in tumors and response to anti-PD-1 in triple-negative breast cancer E Marcheteau, T Farge, M Pérès, G Labrousse, J Tenet, S Delmas, ... Cancers 13 (16), 4059, 2021 | 12 | 2021 |
Dendrogenin A enhances anti-leukemic effect of anthracycline in acute myeloid leukemia PL Mouchel, N Serhan, R Betous, T Farge, E Saland, P De Medina, ... Cancers 12 (10), 2933, 2020 | 9 | 2020 |
The combination of ATRA and dasatinib for differentiation therapy in acute myeloid leukemias with IDH mutations H Boutzen, E Saland, M Cathebras, C Larrue, T Farge, N Serhan, ... Blood 126 (23), 2542, 2015 | 5 | 2015 |
C/EBPα confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress in FLT3-mutant leukemia M Sabatier, R Birsen, L Lauture, J Dehairs, P Angelino, S Mouche, ... bioRxiv, 2022.04. 15.488522, 2022 | 2 | 2022 |
Mitochondrial determinants of response and resistance to venetoclax plus cytarabine duplet therapy in acute myeloid leukemia C Bosc, N Gadaud, A Bousard, M Sabatier, G Cognet, E Saland, T Farge, ... BioRxiv, 2020.08. 17.253856, 2020 | 2 | 2020 |
Inflammation regulates long non-coding RNA-PTTG1-1: 1 in myeloid leukemia S Chateauvieux, A Gaigneaux, D Gérard, M Orsini, F Morceau, ... haematologica 105 (6), e280, 2020 | 2 | 2020 |