| Human induced pluripotent stem cell-derived microglia-like cells harboring TREM2 missense mutations show specific deficits in phagocytosis P Garcia-Reitboeck, A Phillips, TM Piers, C Villegas-Llerena, M Butler, ... Cell Reports 24 (9), 2300-2311, 2018 | 158 | 2018 |
| Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions W Liu, O Taso, R Wang, S Bayram, AC Graham, P Garcia-Reitboeck, ... Human molecular genetics 29 (19), 3224-3248, 2020 | 150 | 2020 |
| The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans X Xiang, TM Piers, B Wefers, K Zhu, A Mallach, B Brunner, G Kleinberger, ... Molecular neurodegeneration 13, 1-14, 2018 | 129 | 2018 |
| A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia TM Piers, K Cosker, A Mallach, GT Johnson, R Guerreiro, J Hardy, ... The FASEB Journal 34 (2), 2436-2450, 2020 | 124 | 2020 |
| Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome K Cosker, A Mallach, J Limaye, TM Piers, J Staddon, SJ Neame, J Hardy, ... Scientific Reports 11 (1), 13316, 2021 | 50 | 2021 |
| Post mortem examination of Parkinson's disease brains suggests decline in mitochondrial biomass, reversed by deep brain stimulation of subthalamic nucleus A Mallach, M Weinert, J Arthur, D Gveric, TS Tierney, KN Alavian The FASEB Journal 33 (6), 6957-6961, 2019 | 28 | 2019 |
| Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer’s disease mouse model, as revealed by spatial transcriptomics A Mallach, M Zielonka, V van Lieshout, Y An, JH Khoo, M Vanheusden, ... Cell Reports 43 (6), 2024 | 20 | 2024 |
| Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss AS Popescu, CA Butler, DH Allendorf, TM Piers, A Mallach, J Roewe, ... Glia 71 (4), 974-990, 2023 | 20 | 2023 |
| Differential stimulation of pluripotent stem cell-derived human microglia leads to exosomal proteomic changes affecting neurons A Mallach, J Gobom, C Arber, TM Piers, J Hardy, S Wray, H Zetterberg, ... Cells 10 (11), 2866, 2021 | 14 | 2021 |
| The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles A Mallach, J Gobom, H Zetterberg, J Hardy, TM Piers, S Wray, JM Pocock Brain communications 3 (2), fcab009, 2021 | 14 | 2021 |
| Molecular basis for mitochondrial signaling DP Hoogerheide, A Rovini, SM Bezrukov Springer, 2017 | 7 | 2017 |
| Microglial signalling pathway deficits associated with the R47H TREM2 variant linked to AD indicate inability to activate inflammasome K Cosker, A Mallach, J Limaye, TM Piers, J Staddon, SJ Neame, J Hardy, ... Biorxiv, 2020.09. 08.288043, 2020 | 4 | 2020 |
| The 18 kDa Translocator protein (TSPO): cholesterol trafficking and the biology of a prognostic and therapeutic mitochondrial target M Frison, AK Mallach, E Kennedy, M Campanella Molecular basis for mitochondrial signaling, 285-315, 2017 | 4 | 2017 |
| Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2 I Nazish, A Mamais, A Mallach, C Bettencourt, A Kaganovich, T Warner, ... Cells 13 (1), 53, 2023 | 1 | 2023 |
| Applying high-resolution spatial transcriptomics to characterize the amyloid plaque cell niche in Alzheimer’s Disease A Mallach, M Zielonka, V van Lieshout, Y An, JH Khoo, M Vanheusden, ... bioRxiv, 2023.06. 29.546675, 2023 | 1 | 2023 |
| Fibrinogen signalling in human iPSC-derived microglia K Cosker, E Boorman, F Vasilopoulou, A Mallach, TM Piers, JM Pocock | | 2024 |
| Characterising functional effects of fibrinogen on TREM2-mutant human iPS-microglia E Boorman, A Mallach, L van Husen, Y Wang, J Pocock GLIA 71, E305-E305, 2023 | | 2023 |
| Microglial exosome secretion coupled to TREM2: implications on neuron-like cells AK Mallach UCL (University College London), 2021 | | 2021 |
| Brain Communications A Mallach, J Gobom, H Zetterberg, J Hardy, TM Piers, S Wray, JM Pocock | | 2021 |
| Exosome secretion from TREM2 mutant iPS microglia like cells: effect on neuron-like cells A Mallach, T Piers, J Pocock GLIA 67, E524-E524, 2019 | | 2019 |
