Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines Q Cao, C Anyansi, X Hu, L Xu, L Xiong, W Tang, MTS Mok, C Cheng, ... Nature genetics 49 (10), 1428-1436, 2017 | 228 | 2017 |
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy J Zhou, M Liu, H Sun, Y Feng, L Xu, AWH Chan, JH Tong, J Wong, ... Gut 67 (5), 931-944, 2018 | 193 | 2018 |
Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors L Xu, C Zou, S Zhang, TSM Chu, Y Zhang, W Chen, C Zhao, L Yang, Z Xu, ... Journal of hematology & oncology 15 (1), 87, 2022 | 110 | 2022 |
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma W Yang, Y Feng, J Zhou, OKW Cheung, J Cao, J Wang, W Tang, Y Tu, ... Science translational medicine 13 (588), eaaz6804, 2021 | 105 | 2021 |
Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer Y Jia, P Li, L Fang, H Zhu, L Xu, H Cheng, J Zhang, F Li, Y Feng, Y Li, J Li, ... Cell discovery 2 (1), 1-20, 2016 | 104 | 2016 |
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma H Sun, W Yang, Y Tian, X Zeng, J Zhou, MTS Mok, W Tang, Y Feng, L Xu, ... Nature communications 9 (1), 5214, 2018 | 98 | 2018 |
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming L Xiong, F Wu, Q Wu, L Xu, OK Cheung, W Kang, MT Mok, LLM Szeto, ... Nature communications 10 (1), 335, 2019 | 91 | 2019 |
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis YY Lee, MTS Mok, W Kang, W Yang, W Tang, F Wu, L Xu, M Yan, Z Yu, ... Nucleic acids research 46 (17), 8832-8847, 2018 | 41 | 2018 |
Dysregulated lysine acetyltransferase 2B promotes inflammatory bowel disease pathogenesis through transcriptional repression of interleukin-10 AHC Bai, WKK Wu, L Xu, SH Wong, MY Go, AWH Chan, M Harbord, ... Journal of Crohn's and Colitis 10 (6), 726-734, 2016 | 37 | 2016 |
Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers B Li, H Chen, S Yang, F Chen, L Xu, Y Li, M Li, C Zhu, F Shao, X Zhang, ... Molecular cancer 22 (1), 71, 2023 | 28 | 2023 |
Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis F Wu, L Xu, Y Tu, OKW Cheung, LLM Szeto, MTS Mok, W Yang, W Kang, ... Cancer letters 525, 115-130, 2022 | 25 | 2022 |
Immune related biomarkers for cancer metastasis to the brain WW Chen, TSM Chu, LL Xu, CN Zhao, WS Poon, GKK Leung, FM Kong Experimental Hematology & Oncology 11 (1), 105, 2022 | 5 | 2022 |
Unveiling KLHL23 as a key immune regulator in hepatocellular carcinoma through integrated analysis L Xu, B Li, Y Liu, Z Hu, Q Dan, B Xu, H Xiang, Y Chen, T Zheng, D Sun, ... Aging (Albany NY) 16 (22), 13608, 2024 | | 2024 |