Követés
Alex Gutteridge
Alex Gutteridge
Head of Bioinformatics at Dunad Therapeutics
E-mail megerősítve itt: dunadtx.com
Cím
Hivatkozott rá
Hivatkozott rá
Év
Prediction of drug–target interaction networks from the integration of chemical and genomic spaces
Y Yamanishi, M Araki, A Gutteridge, W Honda, M Kanehisa
Bioinformatics 24 (13), i232-i240, 2008
12382008
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
J Zheng, V Haberland, D Baird, V Walker, PC Haycock, MR Hurle, ...
Nature genetics 52 (10), 1122-1131, 2020
5552020
Understanding nature's catalytic toolkit
A Gutteridge, JM Thornton
Trends in biochemical sciences 30 (11), 622-629, 2005
2942005
SBML Level 3: an extensible format for the exchange and reuse of biological models
SM Keating, D Waltemath, M König, F Zhang, A Dräger, C Chaouiya, ...
Molecular systems biology 16 (8), e9110, 2020
2522020
Using a neural network and spatial clustering to predict the location of active sites in enzymes
A Gutteridge, GJ Bartlett, JM Thornton
Journal of molecular biology 330 (4), 719-734, 2003
2462003
Single-cell RNAseq reveals seven classes of colonic sensory neuron
JRF Hockley, TS Taylor, G Callejo, AL Wilbrey, A Gutteridge, K Bach, ...
Gut 68 (4), 633-644, 2019
2402019
Molecular and functional variation in iPSC-derived sensory neurons
J Schwartzentruber, S Foskolou, H Kilpinen, J Rodrigues, K Alasoo, ...
Nature genetics 50 (1), 54-61, 2018
2252018
Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia
L Cao, A McDonnell, A Nitzsche, A Alexandrou, PP Saintot, AJC Loucif, ...
Science translational medicine 8 (335), 335ra56-335ra56, 2016
2062016
Conformational changes observed in enzyme crystal structures upon substrate binding
A Gutteridge, J Thornton
Journal of molecular biology 346 (1), 21-28, 2005
1972005
Subtype-selective small molecule inhibitors reveal a fundamental role for Nav1. 7 in nociceptor electrogenesis, axonal conduction and presynaptic release
AJ Alexandrou, AR Brown, ML Chapman, M Estacion, J Turner, MA Mis, ...
PloS one 11 (4), e0152405, 2016
1872016
Characterizing human stem cell–derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research
GT Young, A Gutteridge, HDE Fox, AL Wilbrey, L Cao, LT Cho, AR Brown, ...
Molecular Therapy 22 (8), 1530-1543, 2014
1582014
MIMOX: a web tool for phage display based epitope mapping
J Huang, A Gutteridge, W Honda, M Kanehisa
BMC bioinformatics 7, 1-10, 2006
1272006
Conformational change in substrate binding, catalysis and product release: an open and shut case?
A Gutteridge, J Thornton
FEBS letters 567 (1), 67-73, 2004
1182004
Directing differentiation of human embryonic stem cells toward anterior neural ectoderm using small molecules
B Surmacz, H Fox, A Gutteridge, S Lubitz, P Whiting
Stem Cells 30 (9), 1875-1884, 2012
1002012
Effective function annotation through catalytic residue conservation
RA George, RV Spriggs, GJ Bartlett, A Gutteridge, MW MacArthur, ...
Proceedings of the National Academy of Sciences 102 (35), 12299-12304, 2005
892005
Nutrient control of eukaryote cell growth: a systems biology study in yeast
A Gutteridge, P Pir, JI Castrillo, PD Charles, KS Lilley, SG Oliver
BMC biology 8, 1-20, 2010
882010
Molecular mechanisms mediating retinal reactive gliosis following bone marrow mesenchymal stem cell transplantation
A Tassoni, A Gutteridge, AC Barber, A Osborne, KR Martin
Stem cells 33 (10), 3006-3016, 2015
852015
Optimizing the leveraging of real-world data to improve the development and use of medicines
ML Berger, C Lipset, A Gutteridge, K Axelsen, P Subedi, D Madigan
Value in Health 18 (1), 127-130, 2015
792015
The genetic control of growth rate: a systems biology study in yeast
P Pir, A Gutteridge, J Wu, B Rash, DB Kell, N Zhang, SG Oliver
BMC systems biology 6, 1-17, 2012
722012
Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle
A Fisher, RA Seaborne, TM Hughes, A Gutteridge, CE Stewart, ...
FASEB journal, 2017
642017
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Cikkek 1–20