| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13583* | 2021 |
| The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands LA Cowart, S Wei, MH Hsu, EF Johnson, MU Krishna, JR Falck, ... Journal of Biological Chemistry 277 (38), 35105-35112, 2002 | 236 | 2002 |
| Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes SB Russo, CF Baicu, A Van Laer, T Geng, H Kasiganesan, MR Zile, ... The Journal of clinical investigation 122 (11), 3919-3930, 2012 | 219 | 2012 |
| Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes BA Law, X Liao, KS Moore, A Southard, P Roddy, R Ji, Z Szulc, ... The FASEB Journal 32 (3), 1403, 2018 | 199 | 2018 |
| Sphingolipids in metabolic disease: The good, the bad, and the unknown CD Green, M Maceyka, LA Cowart, S Spiegel Cell metabolism 33 (7), 1293-1306, 2021 | 189 | 2021 |
| Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae F Alvarez-Vasquez, KJ Sims, LA Cowart, Y Okamoto, EO Voit, YA Hannun Nature 433 (7024), 425-430, 2005 | 179 | 2005 |
| Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function LA Cowart, LM Obeid Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2007 | 171 | 2007 |
| Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity B Jaishy, Q Zhang, HS Chung, C Riehle, J Soto, S Jenkins, P Abel, ... Journal of lipid research 56 (3), 546-561, 2015 | 123 | 2015 |
| Sphingolipids in obesity, type 2 diabetes, and metabolic disease SB Russo, JS Ross, LA Cowart Sphingolipids in disease, 373-401, 2013 | 122 | 2013 |
| Sphingolipids: players in the pathology of metabolic disease LA Cowart Trends in Endocrinology & Metabolism 20 (1), 34-42, 2009 | 108 | 2009 |
| Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins GM Jenkins, LA Cowart, P Signorelli, BJ Pettus, CE Chalfant, YA Hannun Journal of Biological Chemistry 277 (45), 42572-42578, 2002 | 106 | 2002 |
| SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes T Geng, A Sutter, MD Harland, BA Law, JS Ross, D Lewin, A Palanisamy, ... Journal of lipid research 56 (12), 2359-2371, 2015 | 105 | 2015 |
| Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity W Hu, J Bielawski, F Samad, AH Merrill Jr, LA Cowart Journal of lipid research 50 (9), 1852-1862, 2009 | 103 | 2009 |
| Isc1 regulates sphingolipid metabolism in yeast mitochondria H Kitagaki, LA Cowart, N Matmati, SV de Avalos, SA Novgorodov, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1768 (11), 2849-2861, 2007 | 102 | 2007 |
| Sphingolipids function as downstream effectors of a fungal PAQR NY Villa, BR Kupchak, I Garitaonandia, JL Smith, E Alonso, C Alford, ... Molecular pharmacology 75 (4), 866-875, 2009 | 100 | 2009 |
| Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance W Hu, J Ross, T Geng, SE Brice, LA Cowart Journal of Biological Chemistry 286 (19), 16596-16605, 2011 | 99 | 2011 |
| Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages J Jin, X Zhang, Z Lu, DM Perry, Y Li, SB Russo, LA Cowart, YA Hannun, ... American Journal of Physiology-Endocrinology and Metabolism 305 (7), E853-E867, 2013 | 97 | 2013 |
| Myristate-derived d16: 0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties SB Russo, R Tidhar, AH Futerman, LA Cowart Journal of Biological Chemistry 288 (19), 13397-13409, 2013 | 86 | 2013 |
| Modulation of sphingolipid metabolism by the phosphatidylinositol-4-phosphate phosphatase Sac1p through regulation of phosphatidylinositol in Saccharomyces cerevisiae SE Brice, CW Alford, LA Cowart Journal of Biological Chemistry 284 (12), 7588-7596, 2009 | 81 | 2009 |
| Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis LA Cowart, YA Hannun Journal of Biological Chemistry 282 (16), 12330-12340, 2007 | 81 | 2007 |
