Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents Á Póti, H Gyergyák, E Németh, O Rusz, S Tóth, C Kovácsházi, D Chen, ... Genome biology 20, 1-13, 2019 | 107 | 2019 |
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers RA DeWeerd, E Németh, Á Póti, N Petryk, CL Chen, O Hyrien, D Szüts, ... Cell reports 38 (12), 2022 | 41 | 2022 |
BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1 D Chen, JZ Gervai, Á Póti, E Németh, Z Szeltner, B Szikriszt, Z Gyüre, ... Nature communications 13 (1), 226, 2022 | 33 | 2022 |
A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms B Szikriszt, Á Póti, E Németh, N Kanu, C Swanton, D Szüts Mutagenesis 36 (1), 75-86, 2021 | 29 | 2021 |
Two main mutational processes operate in the absence of DNA mismatch repair E Németh, A Lovrics, JZ Gervai, M Seki, G Rospo, A Bardelli, D Szüts DNA repair 89, 102827, 2020 | 25 | 2020 |
Precision-engineered reporter cell lines reveal ABCG2 regulation in live lung cancer cells D Kovacsics, A Brózik, B Tihanyi, Z Matula, A Borsy, N Mészáros, E Szabó, ... Biochemical Pharmacology 175, 113865, 2020 | 21 | 2020 |
The role of the N-terminal loop in the function of the colicin E7 nuclease domain A Czene, E Németh, IG Zóka, NI Jakab-Simon, T Körtvélyesi, K Nagata, ... JBIC Journal of Biological Inorganic Chemistry 18, 309-321, 2013 | 20 | 2013 |
Fine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N‐terminal mutations E Németh, T Körtvélyesi, PW Thulstrup, HEM Christensen, M Kožíšek, ... Protein Science 23 (8), 1113-1122, 2014 | 19 | 2014 |
Spontaneous mutagenesis in human cells is controlled by REV1-Polymerase ζ and PRIMPOL Z Gyüre, Á Póti, E Németh, B Szikriszt, R Lózsa, M Krawczyk, ... Cell Reports 42 (8), 2023 | 18 | 2023 |
Design of a colicin E7 based chimeric zinc-finger nuclease E Németh, GK Schilli, G Nagy, C Hasenhindl, B Gyurcsik, C Oostenbrink Journal of Computer-Aided Molecular Design 28, 841-850, 2014 | 16 | 2014 |
Preorganization of the catalytic Zn2+-binding site in the HNH nuclease motif—A solution study E Németh, M Kožíšek, GK Schilli, B Gyurcsik Journal of Inorganic Biochemistry 151, 143-149, 2015 | 15 | 2015 |
A study on the secondary structure of the metalloregulatory protein CueR: effect of pH, metal ions and DNA RK Balogh, E Németh, NC Jones, SV Hoffmann, A Jancsó, B Gyurcsik European Biophysics Journal 50 (3), 491-500, 2021 | 10 | 2021 |
Substrate binding activates the designed triple mutant of the colicin E7 metallonuclease E Németh, T Körtvélyesi, M Kožíšek, PW Thulstrup, HEM Christensen, ... JBIC Journal of Biological Inorganic Chemistry 19, 1295-1303, 2014 | 10 | 2014 |
A new insight into the zinc-dependent DNA-cleavage by the colicin E7 nuclease: a crystallographic and computational study A Czene, E Tóth, E Németh, H Otten, JCN Poulsen, HEM Christensen, ... Metallomics 6 (11), 2090-2099, 2014 | 10 | 2014 |
Intrinsic protein disorder could be overlooked in cocrystallization conditions: An SRCD case study E Németh, RK Balogh, K Borsos, A Czene, PW Thulstrup, B Gyurcsik Protein Science 25 (11), 1977-1988, 2016 | 9 | 2016 |
Chemical Approach to Biological Safety: Molecular‐Level Control of an Integrated Zinc Finger Nuclease E Németh, MN Asaka, K Kato, Z Fábián, C Oostenbrink, HEM Christensen, ... ChemBioChem 19 (1), 66-75, 2018 | 7 | 2018 |
The genomic imprint of cancer therapies helps timing the formation of metastases E Németh, M Krzystanek, L Reiniger, D Ribli, O Pipek, Z Sztupinszki, ... International journal of cancer 145 (3), 694-704, 2019 | 6 | 2019 |
DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis R Lózsa, E Németh, JZ Gervai, BG Márkus, S Kollarics, Z Gyüre, J Tóth, ... Nucleic Acids Research 51 (20), 11040-11055, 2023 | 5 | 2023 |
Recent results in the development of genebank technologies specialized for medicinal plants. E Tóth, É Németh | 4 | 1996 |
Cisplatin is more mutagenic than carboplatin or oxaliplatin at equitoxic concentrations B Szikriszt, Á Póti, E Németh, N Kanu, C Swanton, D Szüts bioRxiv, 2020.08. 11.245969, 2020 | 2 | 2020 |