| TREM2 modulation remodels the tumor myeloid landscape enhancing anti-PD-1 immunotherapy M Molgora, E Esaulova, W Vermi, J Hou, Y Chen, J Luo, S Brioschi, ... Cell 182 (4), 886-900. e17, 2020 | 501 | 2020 |
| Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice? Y Chen, M Colonna Journal of Experimental Medicine 218 (9), 2021 | 238 | 2021 |
| TREM2 drives microglia response to amyloid-β via SYK-dependent and-independent pathways S Wang, R Sudan, V Peng, Y Zhou, S Du, CM Yuede, T Lei, J Hou, Z Cai, ... Cell 185 (22), 4153-4169. e19, 2022 | 211 | 2022 |
| Apolipoprotein E: structural insights and links to Alzheimer disease pathogenesis Y Chen, MR Strickland, A Soranno, DM Holtzman Neuron 109 (2), 205-221, 2021 | 207 | 2021 |
| Activated microglia mitigate Aβ-associated tau seeding and spreading M Gratuze, Y Chen, S Parhizkar, N Jain, MR Strickland, JR Serrano, ... Journal of Experimental Medicine 218 (8), e20210542, 2021 | 151 | 2021 |
| TREM2 dependent and independent functions of microglia in Alzheimer’s disease J Hou, Y Chen, G Grajales-Reyes, M Colonna Molecular neurodegeneration 17 (1), 84, 2022 | 96 | 2022 |
| Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma D Kirschenbaum, K Xie, F Ingelfinger, Y Katzenelenbogen, K Abadie, ... Cell 187 (1), 149-165. e23, 2024 | 76 | 2024 |
| APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread Y Chen, S Song, S Parhizkar, J Lord, Y Zhu, MR Strickland, C Wang, ... Cell 187 (2), 428-445. e20, 2024 | 51 | 2024 |
| TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma R Sun, R Han, C McCornack, S Khan, GT Tabor, Y Chen, J Hou, H Jiang, ... Science Advances 9 (19), eade3559, 2023 | 50 | 2023 |
| Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice S Parhizkar, G Gent, Y Chen, N Rensing, M Gratuze, G Strout, S Sviben, ... Science translational medicine 15 (693), eade6285, 2023 | 43 | 2023 |
| Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination J Hou, Y Zhou, Z Cai, M Terekhova, A Swain, PS Andhey, RM Guimaraes, ... Cell reports 42 (4), 2023 | 37 | 2023 |
| Probing the ATP site of GRP78 with nucleotide triphosphate analogs SJ Hughes, T Antoshchenko, Y Chen, H Lu, JC Pizarro, HW Park PloS one 11 (5), e0154862, 2016 | 37 | 2016 |
| Repurposing drugs to target the malaria parasite unfolding protein response Y Chen, C Murillo-Solano, MG Kirkpatrick, T Antoshchenko, HW Park, ... Scientific Reports 8 (1), 10333, 2018 | 36 | 2018 |
| Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53 T Chao, X Zhou, B Cao, P Liao, H Liu, Y Chen, HW Park, SX Zeng, H Lu Nature communications 7 (1), 13755, 2016 | 35 | 2016 |
| Two-faced behavior of microglia in Alzheimer’s disease Y Chen, M Colonna Nature neuroscience 25 (1), 3-4, 2022 | 33 | 2022 |
| Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains TM Bigley, M Xiong, M Ali, Y Chen, C Wang, JR Serrano, A Eteleeb, ... Molecular neurodegeneration 17 (1), 10, 2022 | 13 | 2022 |
| Spontaneous and induced adaptive immune responses in Alzheimer’s disease: new insights into old observations Y Chen, M Colonna Current Opinion in Immunology 77, 102233, 2022 | 12 | 2022 |
| New insights into innate immunity in Alzheimer’s disease: From APOE protective variants to therapies Y Chen, DM Holtzman Trends in Immunology 45 (10), 768-782, 2024 | 5 | 2024 |
| A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside … A Mrozek, T Antoshchenko, Y Chen, C Zepeda-Velázquez, D Smil, ... Frontiers in molecular biosciences 9, 956095, 2022 | 3 | 2022 |
| Microglia esprit de corps: sharing the burden of eliminating toxic aggregates Y Chen, M Colonna Cell 184 (20), 5082-5084, 2021 | 3 | 2021 |
Marco ColonnaWashington University St LouisE-mail megerősítve itt: wustl.edu