Ikuti
Jian Jin
Jian Jin
Professor, Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Email yang diverifikasi di mssm.edu
Judul
Dikutip oleh
Dikutip oleh
Tahun
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8852015
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
8702012
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
5802011
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
4982013
Advancing targeted protein degradation for cancer therapy
B Dale, M Cheng, KS Park, HÜ Kaniskan, Y Xiong, J Jin
Nature Reviews Cancer 21 (10), 638-654, 2021
4252021
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
HS Huang, JA Allen, AM Mabb, IF King, J Miriyala, B Taylor-Blake, ...
Nature 481 (7380), 185-189, 2012
4162012
Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ...
Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011
3972011
Inhibition of lapatinib-induced kinome reprogramming in ERBB2-positive breast cancer by targeting BET family bromodomains
TJ Stuhlmiller, SM Miller, JS Zawistowski, K Nakamura, AS Beltran, ...
Cell reports 11 (3), 390-404, 2015
3362015
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
Y Nagai, N Miyakawa, H Takuwa, Y Hori, K Oyama, B Ji, M Takahashi, ...
Nature neuroscience 23 (9), 1157-1167, 2020
3112020
Inhibitors of protein methyltransferases and demethylases
HU Kaniskan, ML Martini, J Jin
Chemical reviews 118 (3), 989-1068, 2018
2982018
Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
S Vatansever, A Schlessinger, D Wacker, HÜ Kaniskan, J Jin, MM Zhou, ...
Medicinal research reviews 41 (3), 1427-1473, 2021
2972021
Light-induced control of protein destruction by opto-PROTAC
J Liu, H Chen, L Ma, Z He, D Wang, Y Liu, Q Lin, T Zhang, N Gray, ...
Science advances 6 (8), eaay5154, 2020
2922020
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
2832013
Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity
BD Wallace, AB Roberts, RM Pollet, JD Ingle, KA Biernat, SJ Pellock, ...
Chemistry & biology 22 (9), 1238-1249, 2015
2802015
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
XP Huang, J Karpiak, WK Kroeze, H Zhu, X Chen, SS Moy, KA Saddoris, ...
Nature 527 (7579), 477-483, 2015
2782015
In silico design of novel probes for the atypical opioid receptor MRGPRX2
K Lansu, J Karpiak, J Liu, XP Huang, JD McCorvy, WK Kroeze, T Che, ...
Nature chemical biology 13 (5), 529-536, 2017
2702017
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases
MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ...
ACS chemical biology 11 (3), 772-781, 2016
2672016
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ...
Journal of medicinal chemistry 52 (24), 7950-7953, 2009
2572009
Therapeutic targeting of RNA splicing catalysis through inhibition of protein arginine methylation
JY Fong, L Pignata, PA Goy, KC Kawabata, SCW Lee, CM Koh, D Musiani, ...
Cancer cell 36 (2), 194-209. e9, 2019
2552019
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
B Xu, DM On, A Ma, T Parton, KD Konze, SG Pattenden, DF Allison, L Cai, ...
Blood, The Journal of the American Society of Hematology 125 (2), 346-357, 2015
2522015
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