| HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice R Hoefflin, S Harlander, S Schäfer, P Metzger, F Kuo, D Schönenberger, ... Nature communications 11 (1), 4111, 2020 | 211 | 2020 |
| Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours A Gavish, M Tyler, AC Greenwald, R Hoefflin, D Simkin, ... Nature 618 (7965), 598-606, 2023 | 207 | 2023 |
| Integrative spatial analysis reveals a multi-layered organization of glioblastoma AC Greenwald, NG Darnell, R Hoefflin, D Simkin, CW Mount, LNG Castro, ... Cell 187 (10), 2485-2501. e26, 2024 | 76 | 2024 |
| Personalized clinical decision making through implementation of a molecular tumor board: a German single-center experience R Hoefflin, AL Geißler, R Fritsch, R Claus, J Wehrle, P Metzger, M Reiser, ... JCO Precision Oncology 2, 1-16, 2018 | 75 | 2018 |
| Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity R Hoefflin, B Lahrmann, G Warsow, D Hübschmann, C Spath, B Walter, ... Nature Communications 7 (1), ncomms11845, 2016 | 55 | 2016 |
| Transitioning the molecular tumor board from proof of concept to clinical routine: a German single-center analysis R Hoefflin, A Lazarou, ME Hess, M Reiser, J Wehrle, P Metzger, AV Frey, ... Cancers 13 (5), 1151, 2021 | 43 | 2021 |
| Phenotypic drug screening and target validation for improved personalized therapy reveal the complexity of phenotype-genotype correlations in clear cell renal cell carcinoma M Schneider, J Schüler, R Höfflin, N Korzeniewski, C Grüllich, W Roth, ... Urologic Oncology: Seminars and Original Investigations 32 (6), 877-884, 2014 | 13 | 2014 |
| A spatial expression atlas of the adult human proximal small intestine Y Harnik, O Yakubovsky, R Hoefflin, R Novoselsky, K Bahar Halpern, ... Nature 632 (8027), 1101-1109, 2024 | 10 | 2024 |
| Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation—Immune signature … P Apostolova, S Kreutmair, C Toffalori, M Punta, S Unger, AC Burk, ... British journal of haematology 203 (2), 264-281, 2023 | 9 | 2023 |
| ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma P Seidel, A Rubarth, K Zodel, A Peighambari, F Neumann, Y Federkiel, ... JCI insight 7 (24), e156087, 2022 | 9 | 2022 |
| HIF-1alpha and HIF-2alpha differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. Nat Commun. 2020; 11 (1): 4111 R Hoefflin, S Harlander, S Schäfer, P Metzger, F Kuo, D Schönenberger, ... Epub 2020/08/19. doi: 10.1038/s41467-020-17873-3. PubMed PMID: 32807776, 0 | 9 | |
| Transitioning the molecular tumor board from proof of concept to clinical routine: a German single-center analysis. Cancers 13 (5): 1151 R Hoefflin, A Lazarou, ME Hess, M Reiser, J Wehrle, P Metzger, ... | 8 | 2021 |
| Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma R Hoefflin, S Harlander, BA Abhari, A Peighambari, M Adlesic, P Seidel, ... Cancers 13 (19), 4801, 2021 | 5 | 2021 |
| Intratumoral heterogeneity in renal cell carcinoma: Molecular basis and translational implications R Höfflin, W Roth, H Sültmann, C Grüllich, G Hatiboglu, J Nyarangi-Dix, ... Der Urologe 54, 800-803, 2015 | 4 | 2015 |
| Primary Results of Patients with Genitourinary Malignancies Presented at a Molecular Tumor Board J Michaelis, R Himmelsbach, P Metzger, S Lassmann, M Börries, ... Urologia Internationalis 108 (5), 383-391, 2024 | 1 | 2024 |
| Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment D Schmidt, C Endres, R Hoefflin, G Andrieux, M Zwick, N Karantzelis, ... Cancer research 84 (18), 2985-3003, 2024 | | 2024 |
| The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution M Tyler, A Gavish, C Barbolin, R Tschernichovsky, R Hoefflin, M Mints, ... bioRxiv, 2024.10. 11.617836, 2024 | | 2024 |
| Molecular Heterogeneity of Renal Cell Carcinoma W Hou, R Hoefflin, C Grüllich, M Hohenfellner, S Duensing Urologic Oncology, 529-536, 2019 | | 2019 |
| Schwerkranke Krebs-Patienten profitieren von erweiterter Molekular-Diagnostik R Hoefflin TumorDiagn u Ther, 39, 2018 | | 2018 |
| Entstehungsmechanismen der intratumoralen Heterogenität beim Nierenzellkarzinom RF Höfflin | | 2016 |