| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13536* | 2021 |
| Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies JR Mazzulli, YH Xu, Y Sun, AL Knight, PJ McLean, GA Caldwell, ... Cell 146 (1), 37-52, 2011 | 1491 | 2011 |
| Dopamine-modified α-synuclein blocks chaperone-mediated autophagy M Martinez-Vicente, Z Talloczy, S Kaushik, AC Massey, J Mazzulli, ... The Journal of clinical investigation 118 (2), 777-788, 2008 | 837 | 2008 |
| Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease LF Burbulla, P Song, JR Mazzulli, E Zampese, YC Wong, S Jeon, ... Science 357 (6357), 1255-1261, 2017 | 826 | 2017 |
| Patient-customized oligonucleotide therapy for a rare genetic disease J Kim, C Hu, C Moufawad El Achkar, LE Black, J Douville, A Larson, ... New England Journal of Medicine 381 (17), 1644-1652, 2019 | 625 | 2019 |
| Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson’s disease O Cooper, H Seo, S Andrabi, C Guardia-Laguarta, J Graziotto, ... Science translational medicine 4 (141), 141ra90-141ra90, 2012 | 566 | 2012 |
| Identification and rescue of α-synuclein toxicity in Parkinson patient–derived neurons CY Chung, V Khurana, PK Auluck, DF Tardiff, JR Mazzulli, F Soldner, ... Science 342 (6161), 983-987, 2013 | 530 | 2013 |
| Acetylation targets mutant huntingtin to autophagosomes for degradation H Jeong, F Then, TJ Melia, JR Mazzulli, L Cui, JN Savas, C Voisine, ... Cell 137 (1), 60-72, 2009 | 494 | 2009 |
| Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells K Cao, JJ Graziotto, CD Blair, JR Mazzulli, MR Erdos, D Krainc, FS Collins Science translational medicine 3 (89), 89ra58-89ra58, 2011 | 426 | 2011 |
| Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway H Jeong, DE Cohen, L Cui, A Supinski, JN Savas, JR Mazzulli, ... Nature medicine 18 (1), 159-165, 2012 | 408 | 2012 |
| α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models JR Mazzulli, F Zunke, O Isacson, L Studer, D Krainc Proceedings of the National Academy of Sciences 113 (7), 1931-1936, 2016 | 393 | 2016 |
| Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity M Usenovic, E Tresse, JR Mazzulli, JP Taylor, D Krainc Journal of Neuroscience 32 (12), 4240-4246, 2012 | 349 | 2012 |
| Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson's patient midbrain neurons JR Mazzulli, F Zunke, T Tsunemi, NJ Toker, S Jeon, LF Burbulla, ... Journal of Neuroscience 36 (29), 7693-7706, 2016 | 290 | 2016 |
| Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration DE Mor, E Tsika, JR Mazzulli, NS Gould, H Kim, MJ Daniels, S Doshi, ... Nature neuroscience 20 (11), 1560-1568, 2017 | 245 | 2017 |
| Reversible conformational conversion of α-synuclein into toxic assemblies by glucosylceramide F Zunke, AC Moise, NR Belur, E Gelyana, I Stojkovska, H Dzaferbegovic, ... Neuron 97 (1), 92-107. e10, 2018 | 239 | 2018 |
| Parkin and PINK1 patient iPSC-derived midbrain dopamine neurons exhibit mitochondrial dysfunction and α-synuclein accumulation SY Chung, S Kishinevsky, JR Mazzulli, J Graziotto, A Mrejeru, ... Stem cell reports 7 (4), 664-677, 2016 | 231 | 2016 |
| Is Parkinson’s disease a lysosomal disorder? AD Klein, JR Mazzulli Brain 141 (8), 2255-2262, 2018 | 190 | 2018 |
| Cytosolic catechols inhibit α-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates JR Mazzulli, AJ Mishizen, BI Giasson, DR Lynch, SA Thomas, ... Journal of Neuroscience 26 (39), 10068-10078, 2006 | 189 | 2006 |
| Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits PJ Schultheis, SM Fleming, AK Clippinger, J Lewis, T Tsunemi, B Giasson, ... Human molecular genetics 22 (10), 2067-2082, 2013 | 163 | 2013 |
| LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance M Rothaug, F Zunke, JR Mazzulli, M Schweizer, H Altmeppen, ... Proceedings of the National Academy of Sciences 111 (43), 15573-15578, 2014 | 145 | 2014 |