| Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells SB Kim, HR Kim, MC Park, S Cho, PC Goughnour, D Han, I Yoon, YH Kim, ... Journal of Cell Biology 216 (7), 2201-2216, 2017 | 92 | 2017 |
| Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction JH Kim, C Lee, M Lee, H Wang, K Kim, SJ Park, I Yoon, J Jang, H Zhao, ... Nature communications 8 (1), 732, 2017 | 90 | 2017 |
| Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway M Lee, JH Kim, I Yoon, C Lee, M Fallahi Sichani, JS Kang, J Kang, M Guo, ... Proceedings of the National Academy of Sciences 115 (23), E5279-E5288, 2018 | 89 | 2018 |
| Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 I Yoon, M Nam, HK Kim, HS Moon, S Kim, J Jang, JA Song, SJ Jeong, ... Science 367 (6474), 205-210, 2020 | 84 | 2020 |
| Integrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers JH Lee, XM Zhao, I Yoon, JY Lee, NH Kwon, YY Wang, KM Lee, MJ Lee, ... Cell discovery 2 (1), 1-14, 2016 | 81 | 2016 |
| A threonyl-tRNA synthetase-mediated translation initiation machinery SJ Jeong, S Park, LT Nguyen, J Hwang, EY Lee, HK Giong, JS Lee, ... Nature communications 10 (1), 1357, 2019 | 60 | 2019 |
| Functional and pathologic association of aminoacyl-tRNA synthetases with cancer Y Sung, I Yoon, JM Han, S Kim Experimental & Molecular Medicine 54 (5), 553-566, 2022 | 37 | 2022 |
| Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration SJ Jeong, JH Kim, BJ Lim, I Yoon, J Song, H Moon, D Kim, DK Lee, S Kim Experimental & Molecular Medicine 50 (1), e424-e424, 2018 | 37 | 2018 |
| Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation S Kim, I Yoon, J Son, J Park, K Kim, JH Lee, SY Park, BS Kang, JM Han, ... Cell Reports 35 (4), 2021 | 32 | 2021 |
| Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1 S Cho, SB Kim, Y Lee, EC Song, U Kim, HY Kim, JH Suh, PC Goughnour, ... Journal for immunotherapy of cancer 8 (1), e000277, 2020 | 24 | 2020 |
| Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor S Yoon, JH Kim, I Yoon, C Kim, SE Kim, Y Koh, SJ Jeong, J Lee, S Kim, ... Bioorganic & Medicinal Chemistry Letters 26 (13), 3038-3041, 2016 | 19 | 2016 |
| O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine K Kim, HC Yoo, BG Kim, S Kim, Y Sung, I Yoon, YC Yu, SJ Park, JH Kim, ... Nature communications 13 (1), 2904, 2022 | 18 | 2022 |
| Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors S Yoon, JH Kim, Y Koh, PT Tran, J Ann, I Yoon, J Jang, WK Kim, S Lee, ... Bioorganic & Medicinal Chemistry 25 (15), 4145-4152, 2017 | 15 | 2017 |
| Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors S Yoon, D Zuo, JH Kim, I Yoon, J Ann, SE Kim, D Cho, WK Kim, S Lee, ... Bioorganic & Medicinal Chemistry 26 (14), 4073-4079, 2018 | 12 | 2018 |
| Nucleophilic Cyclization/Electrophilic Substitution of (2, 2-Dialkoxyethyl) ureas: Highly Regioselective Access to Novel 4-(Het) arylimidazolidinones and Benzo [d][1, 3 … AV Smolobochkin, AS Gazizov, NK Otegen, JK Voronina, AG Strelnik, ... Synthesis 52 (21), 3263-3271, 2020 | 10 | 2020 |
| Disease association and therapeutic routes of aminoacyl-tRNA synthetases I Yoon, U Kim, J Choi, S Kim Trends in Molecular Medicine 30 (1), 89-105, 2024 | 9 | 2024 |
| AIMP1 negatively regulates adipogenesis by inhibiting PPARγ JH Kim, JH Lee, MC Park, I Yoon, K Kim, M Lee, HS Choi, JM Han, S Kim Journal of cell science 127 (20), 4483-4493, 2014 | 9 | 2014 |
| Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1 I Yoon, S Kim, M Cho, KA You, J Son, C Lee, JH Suh, DJ Bae, JM Kim, ... EMBO Molecular Medicine 15 (7), e16940, 2023 | 8 | 2023 |
| Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of mammalian target of rapamycin complex 1 (mTORC1) S Yoon, SE Kim, JH Kim, I Yoon, PT Tran, J Ann, C Kim, WS Byun, S Lee, ... Bioorganic & Medicinal Chemistry 27 (6), 1099-1109, 2019 | 7 | 2019 |
| EPRS1 Controls the TGF-β Signaling Pathway via Interaction with TβRI in Hepatic Stellate Cell I Yoon, JA Song, JH Suh, S Kim, J Son, JH Kim, SY Jang, KY Hwang, ... Molecular and cellular biology 43 (5), 223-240, 2023 | 3 | 2023 |
