The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability FH Niesen, H Berglund, M Vedadi Nature protocols 2 (9), 2212-2221, 2007 | 2928 | 2007 |
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ... Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006 | 750 | 2006 |
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ... Nature chemical biology 7 (8), 566-574, 2011 | 579 | 2011 |
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth J Zhu, MA Sammons, G Donahue, Z Dou, M Vedadi, M Getlik, ... Nature 525 (7568), 206-211, 2015 | 527 | 2015 |
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1 KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ... ACS chemical biology 8 (6), 1324-1334, 2013 | 501 | 2013 |
Recognition and specificity determinants of the human cbx chromodomains L Kaustov, H Ouyang, M Amaya, A Lemak, N Nady, S Duan, GA Wasney, ... Journal of Biological Chemistry 286 (1), 521-529, 2011 | 360 | 2011 |
A strategy for modulation of enzymes in the ubiquitin system A Ernst, G Avvakumov, J Tong, Y Fan, Y Zhao, P Alberts, A Persaud, ... Science 339 (6119), 590-595, 2013 | 339 | 2013 |
Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity A Schuetz, J Min, A Allali-Hassani, M Schapira, M Shuen, P Loppnau, ... Journal of Biological Chemistry 283 (17), 11355-11363, 2008 | 338 | 2008 |
Structural biology of human H3K9 methyltransferases H Wu, J Min, VV Lunin, T Antoshenko, L Dombrovski, H Zeng, ... PloS one 5 (1), e8570, 2010 | 319 | 2010 |
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin A Schuetz, J Min, T Antoshenko, CL Wang, A Allali-Hassani, A Dong, ... Structure 15 (3), 377-389, 2007 | 313 | 2007 |
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms M Vedadi, J Lew, J Artz, M Amani, Y Zhao, A Dong, GA Wasney, M Gao, ... Molecular and biochemical parasitology 151 (1), 100-110, 2007 | 313 | 2007 |
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia F Grebien, M Vedadi, M Getlik, R Giambruno, A Grover, R Avellino, ... Nature chemical biology 11 (8), 571-578, 2015 | 305 | 2015 |
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ... Nature communications 3 (1), 1288, 2012 | 305 | 2012 |
In situ proteolysis for protein crystallization and structure determination A Dong, X Xu, AM Edwards Nature methods 4 (12), 1019-1021, 2007 | 294 | 2007 |
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ... Journal of medicinal chemistry 56 (21), 8931-8942, 2013 | 287 | 2013 |
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination D Yanling Zhao, G Gish, U Braunschweig, Y Li, Z Ni, FW Schmitges, ... Nature 529 (7584), 48-53, 2016 | 278 | 2016 |
Structural and chemical profiling of the human cytosolic sulfotransferases A Allali-Hassani, PW Pan, L Dombrovski, R Najmanovich, W Tempel, ... PLoS biology 5 (5), e97, 2007 | 274 | 2007 |
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ... ACS chemical biology 11 (3), 772-781, 2016 | 268 | 2016 |
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme DF Ceccarelli, X Tang, B Pelletier, S Orlicky, W Xie, V Plantevin, ... Cell 145 (7), 1075-1087, 2011 | 266 | 2011 |
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ... Journal of medicinal chemistry 52 (24), 7950-7953, 2009 | 258 | 2009 |