Ikuti
Celeste M Karch
Celeste M Karch
Professor of Psychiatry, Washington University in St Louis
Email yang diverifikasi di wustl.edu - Beranda
Judul
Dikutip oleh
Dikutip oleh
Tahun
Alzheimer’s disease risk genes and mechanisms of disease pathogenesis
CM Karch, AM Goate
Biological psychiatry 77 (1), 43-51, 2015
15402015
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ...
Neuron 97 (6), 1284-1298. e7, 2018
5972018
Alzheimer’s disease genetics: from the bench to the clinic
CM Karch, C Cruchaga, AM Goate
Neuron 83 (1), 11-26, 2014
5502014
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
C Cruchaga, CM Karch, SC Jin, BA Benitez, Y Cai, R Guerreiro, O Harari, ...
Nature 505 (7484), 550-554, 2014
5472014
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
NR Barthélemy, Y Li, N Joseph-Mathurin, BA Gordon, J Hassenstab, ...
Nature medicine 26 (3), 398-407, 2020
5282020
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ...
PLoS medicine 14 (3), e1002258, 2017
4302017
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ...
Stem cell reports 9 (2), 600-614, 2017
4292017
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease
C Cruchaga, JSK Kauwe, O Harari, SC Jin, Y Cai, CM Karch, BA Benitez, ...
Neuron 78 (2), 256-268, 2013
4222013
Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains
CM Karch, AT Jeng, P Nowotny, J Cady, C Cruchaga, AM Goate
PloS one 7 (11), e50976, 2012
4042012
Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening
C Wang, ME Ward, R Chen, K Liu, TE Tracy, X Chen, M Xie, PD Sohn, ...
Stem cell reports 9 (4), 1221-1233, 2017
3322017
Coding variants in TREM2 increase risk for Alzheimer's disease
SC Jin, BA Benitez, CM Karch, B Cooper, T Skorupa, D Carrell, JB Norton, ...
Human molecular genetics 23 (21), 5838-5846, 2014
3312014
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang, S Hsu, L Ibanez, ...
Nature neuroscience 22 (11), 1903-1912, 2019
3012019
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
S Da Mesquita, Z Papadopoulos, T Dykstra, L Brase, FG Farias, M Wall, ...
Nature 593 (7858), 255-260, 2021
2832021
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ...
Science translational medicine 11 (505), eaau2291, 2019
2542019
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
TCW Julia, L Qian, NH Pipalia, MJ Chao, SA Liang, Y Shi, BR Jain, ...
Cell 185 (13), 2213-2233. e25, 2022
2352022
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt
Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009
2352009
Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
M Suárez-Calvet, E Morenas-Rodríguez, G Kleinberger, K Schlepckow, ...
Molecular neurodegeneration 14, 1-14, 2019
2332019
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ...
elife 5, e20391, 2016
2192016
Extracellular tau levels are influenced by variability in tau that is associated with tauopathies
CM Karch, AT Jeng, AM Goate
Journal of Biological Chemistry, 2012
2092012
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
A Drieu, S Du, SE Storck, J Rustenhoven, Z Papadopoulos, T Dykstra, ...
Nature 611 (7936), 585-593, 2022
1772022
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