| Search-and-replace genome editing without double-strand breaks or donor DNA AV Anzalone, PB Randolph, JR Davis, AA Sousa, LW Koblan, JM Levy, ... Nature 576 (7785), 149-157, 2019 | 4149 | 2019 |
| Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors AV Anzalone, LW Koblan, DR Liu Nature biotechnology 38 (7), 824-844, 2020 | 1930 | 2020 |
| Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction LW Koblan, JL Doman, C Wilson, JM Levy, T Tay, GA Newby, JP Maianti, ... Nature biotechnology 36 (9), 843-846, 2018 | 929 | 2018 |
| Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C: G-to-T: A base editors with higher efficiency and product purity AC Komor, KT Zhao, MS Packer, NM Gaudelli, AL Waterbury, LW Koblan, ... Science advances 3 (8), eaao4774, 2017 | 871 | 2017 |
| Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity MF Richter, KT Zhao, E Eton, A Lapinaite, GA Newby, BW Thuronyi, ... Nature biotechnology 38 (7), 883-891, 2020 | 813 | 2020 |
| Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses JM Levy, WH Yeh, N Pendse, JR Davis, E Hennessey, R Butcher, ... Nature biomedical engineering 4 (1), 97-110, 2020 | 420 | 2020 |
| Continuous evolution of base editors with expanded target compatibility and improved activity BW Thuronyi, LW Koblan, JM Levy, WH Yeh, C Zheng, GA Newby, ... Nature biotechnology 37 (9), 1070-1079, 2019 | 410 | 2019 |
| In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice LW Koblan, MR Erdos, C Wilson, WA Cabral, JM Levy, ZM Xiong, ... Nature 589 (7843), 608-614, 2021 | 405 | 2021 |
| Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing AV Anzalone, XD Gao, CJ Podracky, AT Nelson, LW Koblan, A Raguram, ... Nature biotechnology 40 (5), 731-740, 2022 | 404 | 2022 |
| Base editing of haematopoietic stem cells rescues sickle cell disease in mice GA Newby, JS Yen, KJ Woodard, T Mayuranathan, CR Lazzarotto, Y Li, ... Nature 595 (7866), 295-302, 2021 | 316 | 2021 |
| Massively parallel assessment of human variants with base editor screens RE Hanna, M Hegde, CR Fagre, PC DeWeirdt, AK Sangree, Z Szegletes, ... Cell 184 (4), 1064-1080. e20, 2021 | 264 | 2021 |
| Efficient C• G-to-G• C base editors developed using CRISPRi screens, target-library analysis, and machine learning LW Koblan, M Arbab, MW Shen, JA Hussmann, AV Anzalone, JL Doman, ... Nature biotechnology 39 (11), 1414-1425, 2021 | 191 | 2021 |
| Adenine base editing in an adult mouse model of tyrosinaemia CQ Song, T Jiang, M Richter, LH Rhym, LW Koblan, MP Zafra, ... Nature biomedical engineering 4 (1), 125-130, 2020 | 190 | 2020 |
| A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity DA Bachovchin, LW Koblan, W Wu, Y Liu, Y Li, P Zhao, I Woznica, Y Shu, ... Nature chemical biology 10 (8), 656-663, 2014 | 93 | 2014 |
| CRISPR technologies for genome, epigenome and transcriptome editing L Villiger, J Joung, L Koblan, J Weissman, OO Abudayyeh, ... Nature Reviews Molecular Cell Biology, 1-24, 2024 | 63 | 2024 |
| Deciphering cell states and genealogies of human haematopoiesis C Weng, F Yu, D Yang, M Poeschla, LA Liggett, MG Jones, X Qiu, ... Nature 627 (8003), 389-398, 2024 | 54 | 2024 |
| High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases JL Bessen, LK Afeyan, V Dančík, LW Koblan, DB Thompson, C Leichner, ... Nature Communications 10 (1), 1937, 2019 | 41 | 2019 |
| Incorporation of unnatural amino acids into proteins using base editing JP Maianti, DR Liu, LW Koblan US Patent 11,542,509, 2023 | 34 | 2023 |
| Base editors and uses thereof DR Liu, LW Koblan, CG Wilson, JL Doman US Patent App. 17/057,398, 2021 | 27 | 2021 |
| Cytosine to guanine base editor DR Liu, LW Koblan US Patent 11,542,496, 2023 | 24 | 2023 |