Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration JV Andersen, KH Markussen, E Jakobsen, A Schousboe, ... Neuropharmacology 196, 108719, 2021 | 274 | 2021 |
Microglia-specific metabolic changes in neurodegeneration BI Aldana Journal of molecular biology 431 (9), 1830-1842, 2019 | 124 | 2019 |
Integrative characterization of the R6/2 mouse model of Huntington’s disease reveals dysfunctional astrocyte metabolism NH Skotte, JV Andersen, A Santos, BI Aldana, CW Willert, A Nørremølle, ... Cell reports 23 (7), 2211-2224, 2018 | 87 | 2018 |
Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B Y Zhang, B Schmid, NK Nikolaisen, MA Rasmussen, BI Aldana, M Agger, ... Stem cell reports 8 (3), 648-658, 2017 | 86 | 2017 |
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease JV Andersen, SK Christensen, EW Westi, M Diaz-delCastillo, H Tanila, ... Neurobiology of disease 148, 105198, 2021 | 79 | 2021 |
Alterations in cerebral cortical glucose and glutamine metabolism precedes amyloid plaques in the APPswe/PSEN1dE9 mouse model of Alzheimer’s disease JV Andersen, SK Christensen, BI Aldana, JD Nissen, H Tanila, ... Neurochemical research 42, 1589-1598, 2017 | 77 | 2017 |
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease JV Andersen, NH Skotte, SK Christensen, FS Polli, M Shabani, ... Cell Death & Disease 12 (11), 954, 2021 | 64 | 2021 |
The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction F Chan, NZ Lax, CM Voss, BI Aldana, S Whyte, A Jenkins, C Nicholson, ... Brain 142 (2), 391-411, 2019 | 63 | 2019 |
Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply JV Andersen, EW Westi, E Jakobsen, N Urruticoechea, K Borges, ... Molecular brain 14, 1-13, 2021 | 58 | 2021 |
Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia BI Aldana, Y Zhang, P Jensen, A Chandrasekaran, SK Christensen, ... Molecular Brain 13, 1-17, 2020 | 58 | 2020 |
Sertraline reduces IL-1β and TNF-α mRNA expression and overcomes their rise induced by seizures in the rat hippocampus M Sitges, CD Gómez, BI Aldana PLoS One 9 (11), e111665, 2014 | 52 | 2014 |
Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function LF McNair, JV Andersen, BI Aldana, MC Hohnholt, JD Nissen, Y Sun, ... Journal of Neuroscience 39 (25), 4847-4863, 2019 | 51 | 2019 |
Functional metabolic mapping reveals highly active branched-chain amino acid metabolism in human astrocytes, which is impaired in iPSC-derived astrocytes in Alzheimer's disease C Salcedo, JV Andersen, KT Vinten, LH Pinborg, HS Waagepetersen, ... Frontiers in aging neuroscience 13, 736580, 2021 | 50 | 2021 |
Warburg effect metabolism drives neoplasia in a Drosophila genetic model of epithelial cancer T Eichenlaub, R Villadsen, FCP Freitas, D Andrejeva, BI Aldana, ... Current Biology 28 (20), 3220-3228. e6, 2018 | 49 | 2018 |
Extensive astrocyte metabolism of γ‐aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex JV Andersen, E Jakobsen, EW Westi, MEK Lie, CM Voss, BI Aldana, ... Glia 68 (12), 2601-2612, 2020 | 40 | 2020 |
Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line B Schmid, KR Prehn, N Nimsanor, BIA Garcia, U Poulsen, I Jørring, ... Stem Cell Research 34, 101349, 2019 | 40 | 2019 |
Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-13C]Glucose and [1,2-13C]Acetate as Substrates LF McNair, R Kornfelt, AB Walls, JV Andersen, BI Aldana, JD Nissen, ... Neurochemical Research 42, 810-826, 2017 | 40 | 2017 |
Lactate-mediated protection of retinal ganglion cells R Vohra, BI Aldana, G Bulli, DM Skytt, H Waagepetersen, LH Bergersen, ... Journal of Molecular Biology 431 (9), 1878-1888, 2019 | 38 | 2019 |
Role of histaminergic system in blood–brain barrier dysfunction associated with neurological disorders I Banuelos-Cabrera, MG Valle-Dorado, BI Aldana, SA Orozco-Suárez, ... Archives of medical research 45 (8), 677-686, 2014 | 35 | 2014 |
Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non‐synaptic mouse brain mitochondria JV Andersen, E Jakobsen, HS Waagepetersen, BI Aldana Journal of Neuroscience Research 97 (8), 961-974, 2019 | 33 | 2019 |