Profound Treg perturbations correlate with COVID-19 severity S Galván-Peña, J Leon, K Chowdhary, DA Michelson, B Vijaykumar, ... Proceedings of the National Academy of Sciences 118 (37), e2111315118, 2021 | 159 | 2021 |
P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner NS Merle, R Paule, J Leon, M Daugan, T Robe-Rybkine, V Poillerat, ... Proceedings of the National Academy of Sciences 116 (13), 6280-6285, 2019 | 116 | 2019 |
Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis I Boudhabhay, V Poillerat, A Grunenwald, C Torset, J Leon, MV Daugan, ... Kidney International 99 (3), 581-597, 2021 | 77 | 2021 |
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction B Lamarthée, A Marchal, S Charbonnier, T Blein, J Leon, E Martin, ... Nature communications 12 (1), 6446, 2021 | 53 | 2021 |
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations D Zemmour, LM Charbonnier, J Leon, E Six, S Keles, M Delville, ... Nature immunology 22 (5), 607-619, 2021 | 48 | 2021 |
Heme drives susceptibility of glomerular endothelium to complement overactivation due to inefficient upregulation of heme oxygenase-1 O May, NS Merle, A Grunenwald, V Gnemmi, J Leon, C Payet, ... Frontiers in Immunology 9, 3008, 2018 | 46 | 2018 |
Complement activation during intravascular hemolysis: Implication for sickle cell disease and hemolytic transfusion reactions NS Merle, I Boudhabhay, J Leon, V Fremeaux-Bacchi, LT Roumenina Transfusion Clinique et Biologique 26 (2), 116-124, 2019 | 45 | 2019 |
FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression RN Ramirez, K Chowdhary, J Leon, D Mathis, C Benoist Science immunology 7 (67), eabj9836, 2022 | 41 | 2022 |
Membranous nephropathy posttransplantation: an update of the pathophysiology and management J Leon, MJ Pérez-Sáez, I Batal, LH Beck Jr, HG Rennke, G Canaud, ... Transplantation 103 (10), 1990-2002, 2019 | 38 | 2019 |
Complement‐driven hemolytic uremic syndrome J Leon, MB LeStang, R Sberro‐Soussan, A Servais, D Anglicheau, ... American Journal of Hematology 98, S44-S56, 2023 | 35 | 2023 |
A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface J Leon, DA Michelson, J Olejnik, K Chowdhary, HS Oh, AJ Hume, ... Proceedings of the National Academy of Sciences 119 (1), e2116853118, 2022 | 33 | 2022 |
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis F Leng, W Zhang, RN Ramirez, J Leon, Y Zhong, L Hou, K Yuki, ... Immunity 55 (8), 1354-1369. e8, 2022 | 29 | 2022 |
Hemopexin as an inhibitor of hemolysis-induced complement activation V Poillerat, T Gentinetta, J Leon, A Wassmer, M Edler, C Torset, D Luo, ... Frontiers in Immunology 11, 1684, 2020 | 27 | 2020 |
Chronic histiocytic intervillositis: manifestation of placental alloantibody-mediated rejection A Benachi, M Rabant, J Martinovic, H Bouchghoul, AJ Vivanti, J Leon, ... American Journal of Obstetrics and Gynecology 225 (6), 662. e1-662. e11, 2021 | 25 | 2021 |
Effect of combined gluten-free, dairy-free diet in children with steroid-resistant nephrotic syndrome: an open pilot trial J Leon, MJ Pérez-Sáez, A Uffing, N Murakami, A Watanabe, P Cureton, ... Kidney international reports 3 (4), 851-860, 2018 | 24 | 2018 |
Efficacy and safety of direct oral anticoagulants in kidney transplantation: a single-center pilot experience J Leon, L Sabbah, O Aubert, D Anglicheau, X Delavenne, J Zuber, ... Transplantation 104 (12), 2625-2631, 2020 | 22 | 2020 |
Immunological impact of a gluten-free dairy-free diet in children with kidney disease: a feasibility study MJ Pérez-Sáez, A Uffing, J Leon, N Murakami, A Watanabe, TJ Borges, ... Frontiers in Immunology 12, 624821, 2021 | 18 | 2021 |
Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction J Leon, K Chowdhary, W Zhang, RN Ramirez, I André, S Hur, D Mathis, ... Cell reports 42 (8), 2023 | 14 | 2023 |
A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control scurfy syndrome M Delville, F Bellier, J Leon, R Klifa, S Lizot, H Vinçon, S Sobrino, ... Blood, The Journal of the American Society of Hematology 137 (17), 2326-2336, 2021 | 13 | 2021 |
Circulating FH protects kidneys from tubular injury during systemic hemolysis NS Merle, J Leon, V Poillerat, A Grunenwald, I Boudhabhay, S Knockaert, ... Frontiers in Immunology 11, 1772, 2020 | 12 | 2020 |