| Reassessment of exosome composition DK Jeppesen, AM Fenix, JL Franklin, JN Higginbotham, Q Zhang, ... Cell 177 (2), 428-445. e18, 2019 | 2493 | 2019 |
| The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor AE Powell, Y Wang, Y Li, EJ Poulin, AL Means, MK Washington, ... Cell 149 (1), 146-158, 2012 | 796 | 2012 |
| Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS MD Beckler, JN Higginbotham, JL Franklin, AJ Ham, PJ Halvey, ... Molecular & cellular proteomics 12 (2), 343-355, 2013 | 625 | 2013 |
| Amphiregulin exosomes increase cancer cell invasion JN Higginbotham, MD Beckler, JD Gephart, JL Franklin, G Bogatcheva, ... Current Biology 21 (9), 779-786, 2011 | 415 | 2011 |
| KRAS-dependent sorting of miRNA to exosomes DJ Cha, JL Franklin, Y Dou, Q Liu, JN Higginbotham, M Demory Beckler, ... Elife 4, e07197, 2015 | 395 | 2015 |
| Transfer of functional cargo in exomeres Q Zhang, JN Higginbotham, DK Jeppesen, YP Yang, W Li, ET McKinley, ... Cell reports 27 (3), 940-954. e6, 2019 | 365 | 2019 |
| Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes Y Dou, DJ Cha, JL Franklin, JN Higginbotham, DK Jeppesen, AM Weaver, ... Scientific reports 6 (1), 37982, 2016 | 326 | 2016 |
| Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets Q Zhang, DK Jeppesen, JN Higginbotham, R Graves-Deal, VQ Trinh, ... Nature cell biology 23 (12), 1240-1254, 2021 | 310 | 2021 |
| The enterocyte microvillus is a vesicle-generating organelle RE McConnell, JN Higginbotham, DA Shifrin, DL Tabb, RJ Coffey, ... Journal of Cell Biology 185 (7), 1285-1298, 2009 | 295 | 2009 |
| Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells SA Hinger, DJ Cha, JL Franklin, JN Higginbotham, Y Dou, J Ping, L Shu, ... Cell reports 25 (3), 715-725. e4, 2018 | 159 | 2018 |
| The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid WJR James N Higginbotham, Prem Seth, R Michael Blaese Hum Gene Ther. 2002 Jan 1;13(1):129-41. doi: 10.1089/10430340152712683. PMID …, 0 | 154* | |
| Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting JN Higginbotham, Q Zhang, DK Jeppesen, AM Scott, HC Manning, ... Journal of Extracellular Vesicles 5 (1), 29254, 2016 | 132 | 2016 |
| Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions DA Shifrin, RE McConnell, R Nambiar, JN Higginbotham, RJ Coffey, ... Current biology 22 (7), 627-631, 2012 | 129 | 2012 |
| Comprehensive isolation of extracellular vesicles and nanoparticles Q Zhang, DK Jeppesen, JN Higginbotham, JL Franklin, RJ Coffey Nature protocols 18 (5), 1462-1487, 2023 | 111 | 2023 |
| Immunodominance of the VH1–46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation … C Tian, GK Luskin, KM Dischert, JN Higginbotham, BE Shepherd, ... The Journal of Immunology 180 (5), 3279-3288, 2008 | 67 | 2008 |
| Evidence for preferential Ig gene usage and differential TdT and exonuclease activities in human naive and memory B cells C Tian, GK Luskin, KM Dischert, JN Higginbotham, BE Shepherd, ... Molecular immunology 44 (9), 2173-2183, 2007 | 67 | 2007 |
| Angiotensin-converting enzyme 2–containing small extracellular vesicles and exomeres bind the severe acute respiratory syndrome coronavirus 2 spike protein Q Zhang, DK Jeppesen, JN Higginbotham, JL Franklin, JE Crowe Jr, ... Gastroenterology 160 (3), 958-961. e3, 2021 | 49* | 2021 |
| Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis Z Cao, C Li, JN Higginbotham, JL Franklin, DL Tabb, R Graves-Deal, ... Molecular & Cellular Proteomics 7 (9), 1651-1667, 2008 | 49 | 2008 |
| Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma … G Nangami, R Koumangoye, JS Goodwin, AM Sakwe, D Marshall, ... Experimental cell research 328 (2), 388-400, 2014 | 47 | 2014 |
| Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia KC Ray, ME Moss, JL Franklin, CJ Weaver, J Higginbotham, Y Song, ... Oncogene 33 (7), 823-831, 2014 | 47 | 2014 |
