Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation LJ Sharpe, V Howe, NA Scott, W Luu, L Phan, JM Berk, M Hochstrasser, ... Journal of Biological Chemistry 294 (7), 2436-2448, 2019 | 45 | 2019 |
The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6 NA Scott, LJ Sharpe, IM Capell-Hattam, SJ Gullo, W Luu, AJ Brown Biochemical Journal 477 (2), 541-555, 2020 | 32 | 2020 |
The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond NA Scott, LJ Sharpe, AJ Brown Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2021 | 28 | 2021 |
Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron NK Chua, NA Scott, AJ Brown Biochemical Journal 476 (18), 2545-2560, 2019 | 16 | 2019 |
Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6 L Qian, NA Scott, IM Capell-Hattam, EA Draper, NM Fenton, W Luu, ... Journal of Lipid Research 64 (5), 100362, 2023 | 13 | 2023 |
The role of the rhomboid superfamily in ER protein quality control: From mechanisms and functions to diseases S Bhaduri, NA Scott, SE Neal Cold Spring Harbor Perspectives in Biology 15 (2), a041248, 2023 | 4 | 2023 |
SC5D is the sixth enzyme in cholesterol biosynthesis targeted by the E3 ubiquitin ligase MARCHF6. NM Fenton, L Qian, NA Scott, EG Paine, LJ Sharpe, AJ Brown Biochimica et Biophysica acta. Molecular and Cell Biology of Lipids, 159482 …, 2024 | 1 | 2024 |
The Mammalian Rhomboid-like Derlins Regulate Endoplasmic Reticulum Morphology E Jordahl, N Scott, S Neal Journal of Biological Chemistry 299 (3), 104080, 2023 | | 2023 |
The E3 ubiquitin ligase MARCHF6 is a critical regulator of cholesterol metabolism N Scott UNSW Sydney, 2021 | | 2021 |
Squalene Monooxygenase at the Nexus between Cholesterol Homeostasis and Proteostasis NK Chua, V Howe, N Jatana, G Hart-Smith, NA Scott, L Thukral, AJ Brown The FASEB Journal 34 (S1), 1-1, 2020 | | 2020 |