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miR‐155 modulates microglia‐mediated immune response by down‐regulating SOCS‐1 and promoting cytokine and nitric oxide production AL Cardoso, JR Guedes, L Pereira de Almeida, MC Pedroso de Lima Immunology 135 (1), 73-88, 2012 | 357 | 2012 |
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease N Deglon, JL Tseng, JC Bensadoun, AD Zurn, Y Arsenijevic, ... Human gene therapy 11 (1), 179-190, 2000 | 355 | 2000 |
Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels L Pereira de Almeida, CA Ross, D Zala, P Aebischer, N Deglon The Journal of Neuroscience 22 (9), 3473-3483, 2002 | 266 | 2002 |
Gene therapy for the CNS using AAVs: the impact of systemic delivery by AAV9 J Saraiva, RJ Nobre, LP de Almeida Journal of Controlled Release 241, 94-109, 2016 | 255 | 2016 |
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease I Nascimento-Ferreira, T Santos-Ferreira, L Sousa-Ferreira, G Auregan, ... Brain 134 (5), 1400-1415, 2011 | 234 | 2011 |
MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma PM Costa, AL Cardoso, C Custódia, P Cunha, LP de Almeida, ... Journal of Controlled Release 207, 31-39, 2015 | 202 | 2015 |
Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease LP de Almeida, D Zala, P Aebischer, N Deglon Neurobiology of disease 8 (3), 433-446, 2001 | 202 | 2001 |
Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease S Alves, I Nascimento-Ferreira, G Auregan, R Hassig, N Dufour, ... PloS one 3 (10), e3341, 2008 | 193 | 2008 |
Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model JR Guedes, CM Custodia, RJ Silva, LP de Almeida, MC Pedroso de Lima, ... Human molecular genetics 23 (23), 6286-6301, 2014 | 184 | 2014 |
Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation? A Marcelo, R Koppenol, LP de Almeida, CA Matos, C Nóbrega Cell death & disease 12 (6), 592, 2021 | 149 | 2021 |
Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado–Joseph disease AT Simoes, N Gonçalves, A Koeppen, N Deglon, S Kügler, CB Duarte, ... Brain 135 (8), 2428-2439, 2012 | 149 | 2012 |
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice C Nóbrega, I Nascimento-Ferreira, I Onofre, D Albuquerque, H Hirai, ... PloS one 8 (1), e52396, 2013 | 145 | 2013 |
Machado–Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy CA Matos, LP de Almeida, C Nóbrega Journal of neurochemistry 148 (1), 8-28, 2019 | 136 | 2019 |
Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases J Duarte-Neves, LP de Almeida, C Cavadas Neurobiology of disease 95, 210-224, 2016 | 133 | 2016 |
Silencing ataxin-3 mitigates degeneration in a rat model of Machado–Joseph disease: no role for wild-type ataxin-3? S Alves, I Nascimento-Ferreira, N Dufour, R Hassig, G Auregan, ... Human molecular genetics 19 (12), 2380-2394, 2010 | 133 | 2010 |
Role of hypothalamic neurogenesis in feeding regulation L Sousa-Ferreira, LP de Almeida, C Cavadas Trends in Endocrinology & Metabolism 25 (2), 80-88, 2014 | 132 | 2014 |
Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's … E Regulier, L Pereira de Almeida, B Sommer, P Aebischer, N Deglon Human gene therapy 13 (16), 1981-1990, 2002 | 131 | 2002 |