Artikel dengan mandat akses publik - Timothy J EganPelajari lebih lanjut
Tidak tersedia di mana pun: 8
Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with Plasmodium falciparum Multidrug Resistance-Associated Protein and …
JG Woodland, R Hunter, PJ Smith, TJ Egan
ACS Chemical Biology 13 (10), 2939-2948, 2018
Mandat: National Research Foundation, South Africa
Synthesis, characterization and pharmacological evaluation of ferrocenyl azines and their rhodium (I) complexes
T Stringer, H Guzgay, JM Combrinck, M Hopper, DT Hendricks, PJ Smith, ...
Journal of Organometallic Chemistry 788, 1-8, 2015
Mandat: National Research Foundation, South Africa
Solution structures of chloroquine–ferriheme complexes modeled using MD simulation and investigated by EXAFS spectroscopy
D Kuter, V Streltsov, N Davydova, GA Venter, KJ Naidoo, TJ Egan
Journal of inorganic biochemistry 154, 114-125, 2016
Mandat: National Research Foundation, South Africa
Fe (III) protoporphyrin IX encapsulated in a zinc metal–organic framework shows dramatically enhanced peroxidatic activity
NA Dare, L Brammer, SA Bourne, TJ Egan
Inorganic Chemistry 57 (3), 1171-1183, 2018
Mandat: National Research Foundation, South Africa
Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates
A Uddin, S Gupta, R Shoaib, B Aneja, I Irfan, K Gupta, N Rawat, ...
European Journal of Medicinal Chemistry 264, 115969, 2024
Mandat: Department of Science & Technology, India
Structural-activity relationship of metallo-aminoquines as next generation antimalarials
M Abid, S Singh, TJ Egan, MC Joshi
Current topics in medicinal chemistry 22 (6), 436-472, 2022
Mandat: Department of Science & Technology, India
THC shows activity against cultured Plasmodium falciparum
ACC de Sousa, JM Combrinck, K Maepa, TJ Egan
Bioorganic & Medicinal Chemistry Letters 54, 128442, 2021
Mandat: National Research Foundation, South Africa
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum, and Synergize with Clinical …
J Okombo, M Kumar, D Redhi, KJ Wicht, L Wiesner, TJ Egan, K Chibale
ACS Infectious Diseases 9 (3), 653-667, 2023
Mandat: UK Medical Research Council, National Research Foundation, South Africa
Tersedia di suatu tempat: 50
Insights into the role of heme in the mechanism of action of antimalarials
JM Combrinck, TE Mabotha, KK Ncokazi, MA Ambele, D Taylor, PJ Smith, ...
ACS chemical biology 8 (1), 133-137, 2013
Mandat: US National Institutes of Health
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
EM Guantai, K Ncokazi, TJ Egan, J Gut, PJ Rosenthal, PJ Smith, ...
Bioorganic & medicinal chemistry 18 (23), 8243-8256, 2010
Mandat: US National Institutes of Health
A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine
SK Dhingra, D Redhi, JM Combrinck, T Yeo, J Okombo, PP Henrich, ...
MBio 8 (3), 10.1128/mbio. 00303-17, 2017
Mandat: US National Institutes of Health, National Research Foundation, South Africa
Enone–and chalcone–chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies
EM Guantai, K Ncokazi, TJ Egan, J Gut, PJ Rosenthal, R Bhampidipati, ...
Journal of medicinal chemistry 54 (10), 3637-3649, 2011
Mandat: US National Institutes of Health
Crystallization of synthetic haemozoin (β-haematin) nucleated at the surface of lipid particles
AN Hoang, KK Ncokazi, KA de Villiers, DW Wright, TJ Egan
Dalton Transactions 39 (5), 1235-1244, 2010
Mandat: US National Institutes of Health
The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor
J Gildenhuys, T Roex, TJ Egan, KA de Villiers
Journal of the American Chemical Society 135 (3), 1037-1047, 2013
Mandat: US National Institutes of Health
The Neutral Lipid Composition Present in the Digestive Vacuole of Plasmodium falciparum Concentrates Heme and Mediates β-Hematin Formation with an …
AN Hoang, RD Sandlin, A Omar, TJ Egan, DW Wright
Biochemistry 49 (47), 10107-10116, 2010
Mandat: US National Institutes of Health
Heme detoxification in the malaria parasite: A target for antimalarial drug development
KA de Villiers, TJ Egan
Accounts of chemical research 54 (11), 2649-2659, 2021
Mandat: US National Institutes of Health, National Research Foundation, South Africa
Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials
JM Combrinck, KY Fong, L Gibhard, PJ Smith, DW Wright, TJ Egan
Malaria journal 14, 1-14, 2015
Mandat: US National Institutes of Health, UK Medical Research Council, National …
Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo [3, 2-c] quinolines with various substituents at C2, C6 …
N Wang, KJ Wicht, K Imai, M Wang, TA Ngoc, R Kiguchi, M Kaiser, ...
Bioorganic & medicinal chemistry 22 (9), 2629-2642, 2014
Mandat: UK Medical Research Council
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in …
K Singh, J Okombo, C Brunschwig, F Ndubi, L Barnard, C Wilkinson, ...
Journal of medicinal chemistry 60 (4), 1432-1448, 2017
Mandat: National Research Foundation, South Africa
Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity
RD Sandlin, KY Fong, KJ Wicht, HM Carrell, TJ Egan, DW Wright
International Journal for Parasitology: Drugs and Drug Resistance 4 (3), 316-325, 2014
Mandat: US National Institutes of Health
Informasi terbitan dan pendanaan ditentukan secara otomatis oleh program komputer