| Uncovering the unexplored diversity of thioamidated ribosomal peptides in Actinobacteria using the RiPPER genome mining tool J Santos-Aberturas, G Chandra, L Frattaruolo, R Lacret, TH Pham, ... Nucleic Acids Research 47 (9), 4624-4637, 2019 | 143 | 2019 |
| PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis N Anton, J Santos-Aberturas, MV Mendes, SM Guerra, JF Martín, ... Microbiology 153 (9), 3174-3183, 2007 | 138 | 2007 |
| Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation JF Aparicio, EG Barreales, TD Payero, CM Vicente, A de Pedro, ... Applied microbiology and biotechnology 100 (1), 61-78, 2016 | 126 | 2016 |
| Fully automatized high‐throughput enzyme library screening using a robotic platform M Dörr, MPC Fibinger, D Last, S Schmidt, J Santos‐Aberturas, D Böttcher, ... Biotechnology and Bioengineering 113 (7), 1421-1432, 2016 | 119 | 2016 |
| Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin MV Mendes, E Recio, N Antón, SM Guerra, J Santos-Aberturas, JF Martín, ... Chemistry & biology 14 (3), 279-290, 2007 | 88 | 2007 |
| Dissecting bottromycin biosynthesis using comparative untargeted metabolomics WJK Crone, NM Vior, J Santos‐Aberturas, LG Schmitz, FJ Leeper, ... Angewandte Chemie 128 (33), 9791-9795, 2016 | 80 | 2016 |
| Functional conservation of PAS–LuxR transcriptional regulators in polyene macrolide biosynthesis J Santos-Aberturas, TD Payero, CM Vicente, SM Guerra, C Canibano, ... Metabolic engineering 13 (6), 756-767, 2011 | 74 | 2011 |
| Structure of cytochrome P450 PimD suggests epoxidation of the polyene macrolide pimaricin occurs via a hydroperoxoferric intermediate PM Kells, H Ouellet, J Santos-Aberturas, JF Aparicio, LM Podust Chemistry & biology 17 (8), 841-851, 2010 | 70 | 2010 |
| Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506) C Barreiro, C Prieto, A Sola-Landa, E Solera, M Martínez-Castro, ... Journal of bacteriology 194 (14), 3756-3757, 2012 | 64 | 2012 |
| Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes J Santos-Aberturas, CM Vicente, SM Guerra, TD Payero, JF Martín, ... Journal of Biological Chemistry 286 (11), 9150-9161, 2011 | 63 | 2011 |
| FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis D Goranovič, M Blažič, V Magdevska, J Horvat, E Kuščer, T Polak, ... BMC microbiology 12, 1-15, 2012 | 59 | 2012 |
| PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis CM Vicente, J Santos-Aberturas, SM Guerra, TD Payero, JF Martín, ... Microbial cell factories 8, 1-13, 2009 | 51 | 2009 |
| In-depth high-throughput screening of protein engineering libraries by split-GFP direct crude cell extract data normalization J Santos-Aberturas, M Dörr, GS Waldo, UT Bornscheuer Chemistry & biology 22 (10), 1406-1414, 2015 | 48 | 2015 |
| PAS-LuxR transcriptional control of filipin biosynthesis in S. avermitilis CM Vicente, J Santos-Aberturas, TD Payero, EG Barreales, A de Pedro, ... Applied microbiology and biotechnology 98, 9311-9324, 2014 | 48 | 2014 |
| Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors F Leipoldt, J Santos-Aberturas, DP Stegmann, F Wolf, A Kulik, R Lacret, ... Nature Communications 8 (1), 1965, 2017 | 44 | 2017 |
| LAL Regulators SCO0877 and SCO7173 as Pleiotropic Modulators of Phosphate Starvation Response and Actinorhodin Biosynthesis in Streptomyces coelicolor SM Guerra, A Rodriguez-Garcia, J Santos-Aberturas, CM Vicente, ... PLoS One 7 (2), e31475, 2012 | 42 | 2012 |
| Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis Y Martínez-Burgo, J Santos-Aberturas, A Rodríguez-García, EG Barreales, ... Frontiers in microbiology 10, 580, 2019 | 38 | 2019 |
| Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives TD Payero, CM Vicente, Á Rumbero, EG Barreales, J Santos-Aberturas, ... Microbial Cell Factories 14, 1-14, 2015 | 38 | 2015 |
| Hierarchical control on polyene macrolide biosynthesis: PimR modulates pimaricin production via the PAS-LuxR transcriptional activator PimM J Santos-Aberturas, CM Vicente, TD Payero, L Martin-Sanchez, ... PLoS One 7 (6), e38536, 2012 | 38 | 2012 |
| Macroamidine formation in bottromycins is catalyzed by a divergent YcaO enzyme L Franz, S Adam, J Santos-Aberturas, AW Truman, J Koehnke Journal of the American Chemical Society 139 (50), 18158-18161, 2017 | 34 | 2017 |
