Ikuti
Paraskevi Giannakakou
Paraskevi Giannakakou
Professor of pharmacology in Medicine, Weill Cornell
Email yang diverifikasi di med.cornell.edu
Judul
Dikutip oleh
Dikutip oleh
Tahun
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation
H Zhang, D Freitas, HS Kim, K Fabijanic, Z Li, H Chen, MT Mark, H Molina, ...
Nature cell biology 20 (3), 332-343, 2018
15582018
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
NJ Mabjeesh, D Escuin, TM LaVallee, VS Pribluda, GM Swartz, ...
Cancer cell 3 (4), 363-375, 2003
9442003
Paclitaxel-resistant human ovarian cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization
P Giannakakou, DL Sackett, YK Kang, Z Zhan, JTM Buters, T Fojo, ...
Journal of Biological Chemistry 272 (27), 17118-17125, 1997
9161997
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®)
RJ Kowalski, P Giannakakou, E Hamel
Journal of Biological Chemistry 272 (4), 2534-2541, 1997
7191997
Synthesis of epothilones A and B in solid and solution phase
KC Nicolaou, N Winssinger, J Pastor, S Ninkovic, F Sarabia, Y He, ...
Nature 387 (6630), 268-272, 1997
6341997
A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
P Giannakakou, R Gussio, E Nogales, KH Downing, D Zaharevitz, ...
Proceedings of the National Academy of Sciences 97 (6), 2904-2909, 2000
6292000
Targeting microtubules for cancer chemotherapy
J Zhou, P Giannakakou
Current Medicinal Chemistry-Anti-Cancer Agents 5 (1), 65-71, 2005
6262005
Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death
MV Blagosklonny, P Giannakakou, WS El-Deiry, DGI Kingston, PI Higgs, ...
Cancer research 57 (1), 130-135, 1997
5171997
Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
TH Wang, HS Wang, H Ichijo, P Giannakakou, JS Foster, T Fojo, ...
Journal of Biological Chemistry 273 (9), 4928-4936, 1998
5031998
Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer
MS Darshan, MS Loftus, M Thadani-Mulero, BP Levy, D Escuin, XK Zhou, ...
Cancer research 71 (18), 6019-6029, 2011
5022011
Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody
JP Gleghorn, ED Pratt, D Denning, H Liu, NH Bander, ST Tagawa, ...
Lab on a Chip 10 (1), 27-29, 2010
4762010
p53 is associated with cellular microtubules and is transported to the nucleus by dynein
P Giannakakou, DL Sackett, Y Ward, KR Webster, MV Blagosklonny, ...
Nature cell biology 2 (10), 709-717, 2000
4672000
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more …
RJ Kowalski, P Giannakakou, SP Gunasekera, RE Longley, BW Day, ...
Molecular pharmacology 52 (4), 613-622, 1997
3421997
Prospective multicenter validation of androgen receptor splice variant 7 and hormone therapy resistance in high-risk castration-resistant prostate cancer: the PROPHECY study
AJ Armstrong, S Halabi, J Luo, DM Nanus, P Giannakakou, ...
Journal of Clinical Oncology 37 (13), 1120-1129, 2019
3392019
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for …
DE Pryor, A O'Brate, G Bilcer, JF Díaz, Y Wang, Y Wang, M Kabaki, ...
Biochemistry 41 (29), 9109-9115, 2002
3112002
Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
P Giannakakou, R Robey, T Fojo, MV Blagosklonny
Oncogene 20 (29), 3806-3813, 2001
3062001
Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device
BJ Kirby, M Jodari, MS Loftus, G Gakhar, ED Pratt, C Chanel-Vos, ...
PloS one 7 (4), e35976, 2012
3012012
The importance of p53 location: nuclear or cytoplasmic zip code?
A O’Brate, P Giannakakou
Drug resistance updates 6 (6), 313-322, 2003
2992003
A SIRT2-selective inhibitor promotes c-Myc oncoprotein degradation and exhibits broad anticancer activity
H Jing, J Hu, B He, YLN Abril, J Stupinski, K Weiser, M Carbonaro, ...
Cancer cell 29 (3), 297-310, 2016
2902016
Androgen receptor splice variants determine taxane sensitivity in prostate cancer
M Thadani-Mulero, L Portella, S Sun, M Sung, A Matov, RL Vessella, ...
Cancer research 74 (8), 2270-2282, 2014
2792014
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