Christian Tyrchan

Dikutip oleh

	Semua	Sejak 2020
Kutipan	5212	3784
indeks-h	30	24
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Akses publik

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14 artikel

3 artikel

tersedia

tidak tersedia

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Ola EngkvistAstraZeneca R&D Gothenburg Orcid:0000-0003-4970-6461Email yang diverifikasi di astrazeneca.com
Matthew W D PerryMedicinal Chemistry, RIA iMed, AstraZenecaEmail yang diverifikasi di astrazeneca.com
Thierry KogejAssociate Principal Scientist, AstraZenecaEmail yang diverifikasi di astrazeneca.com
Hongming ChenAstrazeneca, Bioland Laboratory, Guangzhou LaboratoryEmail yang diverifikasi di grmh-gdl.cn
Eva NittingerComputational Chemistry, BioPharmaceuticals R&D, Early R&I, AstraZenecaEmail yang diverifikasi di astrazeneca.com
Josep Arús-PousEvinova (AstraZeneca)Email yang diverifikasi di evinova.com
Sorel MuresanGlobal R&D Manager Cleaning Goods, Nouryon, Stenungsund SwedenEmail yang diverifikasi di nouryon.com
Werngard CzechtizkyAstraZeneca, Respiratory and ImmunologyEmail yang diverifikasi di astrazeneca.com
Jean-Louis ReymondUniversity of BernEmail yang diverifikasi di unibe.ch
Marwin SeglerMicrosoft Research AI for ScienceEmail yang diverifikasi di microsoft.com
Jiazhen HeAstraZenecaEmail yang diverifikasi di astrazeneca.com
Nils PembertonMedicinal Chemistry, RIA iMed, AstraZenecaEmail yang diverifikasi di astrazeneca.com
Johan UlanderAstraZenecaEmail yang diverifikasi di astrazeneca.com
Richard J LewisMedicinal Chemistry, RIA IMED, AstraZenecaEmail yang diverifikasi di astrazeneca.com
Mark P WallerPending.AIEmail yang diverifikasi di pending.ai
Thomas BlaschkeOdyssey TherapeuticsEmail yang diverifikasi di uni-bonn.de
Dr. Björn OverRhein-Chemotechnik GmbHEmail yang diverifikasi di rhein-chemotechnik.com
Christoph SteinbeckFriedrich-Schiller-University JenaEmail yang diverifikasi di uni-jena.de
Anders HognerDirector Computational Chemistry, Research and Early Development, Cardiovascular, Renal andEmail yang diverifikasi di astrazeneca.com
Peter SjöDrugs for Neglected Disease initiativeEmail yang diverifikasi di dndi.org

Ikuti

Christian Tyrchan

Senior Director Computational Chemistry, BioPharmaceuticals R&D, Early R&I, AstraZeneca

Email yang diverifikasi di astrazeneca.com

Cheminformatics Patentinformatics Structural Design Machine Learning


Judul Urutkan menurut kutipan Urutkan menurut tahun Urutkan menurut judul	Dikutip oleh Dikutip oleh	Tahun
Generating focused molecule libraries for drug discovery with recurrent neural networks MHS Segler, T Kogej, C Tyrchan, MP Waller ACS central science 4 (1), 120-131, 2018	1614	2018
Recent developments of the chemistry development kit (CDK)-an open-source java library for chemo-and bioinformatics C Steinbeck, C Hoppe, S Kuhn, M Floris, R Guha, EL Willighagen Current pharmaceutical design 12 (17), 2111-2120, 2006	577	2006
REINVENT 2.0: an AI tool for de novo drug design T Blaschke, J Arús-Pous, H Chen, C Margreitter, C Tyrchan, O Engkvist, ... Journal of chemical information and modeling 60 (12), 5918-5922, 2020	378	2020
Randomized SMILES strings improve the quality of molecular generative models J Arús-Pous, SV Johansson, O Prykhodko, EJ Bjerrum, C Tyrchan, ... Journal of cheminformatics 11, 1-13, 2019	317	2019
Direct steering of de novo molecular generation with descriptor conditional recurrent neural networks PC Kotsias, J Arús-Pous, H Chen, O Engkvist, C Tyrchan, EJ Bjerrum Nature Machine Intelligence 2 (5), 254-265, 2020	197	2020
Structural and conformational determinants of macrocycle cell permeability B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ... Nature Chemical Biology 12 (12), 1065-1074, 2016	195	2016
SMILES-based deep generative scaffold decorator for de-novo drug design J Arús-Pous, A Patronov, EJ Bjerrum, C Tyrchan, JL Reymond, H Chen, ... Journal of cheminformatics 12, 1-18, 2020	173	2020
Matched molecular pair analysis in short: algorithms, applications and limitations C Tyrchan, E Evertsson Computational and structural biotechnology journal 15, 86-90, 2017	105	2017
Molecular optimization by capturing chemist’s intuition using deep neural networks J He, H You, E Sandström, E Nittinger, EJ Bjerrum, C Tyrchan, ... Journal of cheminformatics 13, 1-17, 2021	100	2021
Making every SAR point count: the development of Chemistry Connect for the large-scale integration of structure and bioactivity data S Muresan, P Petrov, C Southan, MJ Kjellberg, T Kogej, C Tyrchan, ... Drug Discovery Today 16 (23-24), 1019-1030, 2011	97	2011
Structural analysis and prediction of protein mutant stability using distance and torsion potentials: role of secondary structure and solvent accessibility V Parthiban, MM Gromiha, C Hoppe, D Schomburg Proteins: Structure, Function, and Bioinformatics 66 (1), 41-52, 2007	82	2007
Comparison of molecular fingerprint methods on the basis of biological profile data A Steffen, T Kogej, C Tyrchan, O Engkvist Journal of chemical information and modeling 49 (2), 338-347, 2009	74	2009
Annotated chemical patent corpus: a gold standard for text mining SA Akhondi, AG Klenner, C Tyrchan, AK Manchala, K Boppana, D Lowe, ... PloS one 9 (9), e107477, 2014	73	2014
Intramolecular hydrogen bond expectations in medicinal chemistry F Giordanetto, C Tyrchan, J Ulander ACS medicinal chemistry letters 8 (2), 139-142, 2017	72	2017
Prediction of protein thermostability with a direction‐and distance‐dependent knowledge‐based potential C Hoppe, D Schomburg Protein Science 14 (10), 2682-2692, 2005	57	2005
Impact of PROTAC linker plasticity on the solution conformations and dissociation of the ternary complex D Weerakoon, RJ Carbajo, L De Maria, C Tyrchan, H Zhao Journal of Chemical Information and Modeling 62 (2), 340-349, 2022	56	2022
Transformer-based molecular optimization beyond matched molecular pairs J He, E Nittinger, C Tyrchan, W Czechtizky, A Patronov, EJ Bjerrum, ... Journal of cheminformatics 14 (1), 18, 2022	54	2022
A class of highly selective inhibitors bind to an active state of PI3Kγ G Gangadhara, G Dahl, T Bohnacker, R Rae, J Gunnarsson, S Blaho, ... Nature chemical biology 15 (4), 348-357, 2019	53	2019
Discovery of highly isoform selective orally bioavailable phosphoinositide 3-kinase (PI3K)-γ inhibitors N Pemberton, M Mogemark, S Arlbrandt, P Bold, RJ Cox, C Gardelli, ... Journal of Medicinal Chemistry 61 (12), 5435-5441, 2018	44	2018
Physicochemical property profiles of marketed drugs, clinical candidates and bioactive compounds C Tyrchan, N Blomberg, O Engkvist, T Kogej, S Muresan Bioorganic & medicinal chemistry letters 19 (24), 6943-6947, 2009	43	2009

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