| AlphaFold and implications for intrinsically disordered proteins KM Ruff, RV Pappu Journal of Molecular Biology 433 (20), 167208, 2021 | 485 | 2021 |
| Relating sequence encoded information to form and function of intrinsically disordered proteins RK Das, KM Ruff, RV Pappu Current Opinion in Structural Biology 32, 102-112, 2015 | 414 | 2015 |
| Inert and seed-competent tau monomers suggest structural origins of aggregation H Mirbaha, D Chen, OA Morazova, KM Ruff, AM Sharma, X Liu, ... Elife 7, e36584, 2018 | 261 | 2018 |
| Unmasking the roles of N-and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation SL Crick, KM Ruff, K Garai, C Frieden, RV Pappu Proceedings of the National Academy of Sciences 110 (50), 20075-20080, 2013 | 243 | 2013 |
| Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements G Fuertes, N Banterle, KM Ruff, A Chowdhury, D Mercadante, C Koehler, ... Proceedings of the National Academy of Sciences 114 (31), E6342-E6351, 2017 | 219 | 2017 |
| Advances in understanding stimulus-responsive phase behavior of intrinsically disordered protein polymers KM Ruff, S Roberts, A Chilkoti, RV Pappu Journal of molecular biology 430 (23), 4619-4635, 2018 | 211 | 2018 |
| Ligand effects on phase separation of multivalent macromolecules KM Ruff, F Dar, RV Pappu Proceedings of the National Academy of Sciences 118 (10), e2017184118, 2021 | 131 | 2021 |
| PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins T Lazar, E Martínez-Pérez, F Quaglia, A Hatos, LB Chemes, JA Iserte, ... Nucleic Acids Research 49 (D1), D404-D411, 2021 | 128 | 2021 |
| Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers AE Posey, KM Ruff, TS Harmon, SL Crick, A Li, MI Diamond, RV Pappu Journal of Biological Chemistry 293 (10), 3734-3746, 2018 | 124 | 2018 |
| Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths JB Warner IV, KM Ruff, PS Tan, EA Lemke, RV Pappu, HA Lashuel Journal of the American Chemical Society 139 (41), 14456-14469, 2017 | 96 | 2017 |
| Conformational preferences and phase behavior of intrinsically disordered low complexity sequences: insights from multiscale simulations KM Ruff, RV Pappu, AS Holehouse Current opinion in structural biology 56, 1-10, 2019 | 90 | 2019 |
| CAMELOT: A machine learning approach for coarse-grained simulations of aggregation of block-copolymeric protein sequences KM Ruff, TS Harmon, RV Pappu The Journal of chemical physics 143 (24), 12B607_1, 2015 | 87 | 2015 |
| Sequence grammar underlying the unfolding and phase separation of globular proteins KM Ruff, YH Choi, D Cox, AR Ormsby, Y Myung, DB Ascher, SE Radford, ... Molecular cell 82 (17), 3193-3208. e8, 2022 | 78 | 2022 |
| A disordered region controls cBAF activity via condensation and partner recruitment A Patil, AR Strom, JA Paulo, CK Collings, KM Ruff, MK Shinn, A Sankar, ... Cell 186 (22), 4936-4955. e26, 2023 | 74 | 2023 |
| Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length EA Newcombe, KM Ruff, A Sethi, AR Ormsby, YM Ramdzan, A Fox, ... Journal of molecular biology 430 (10), 1442-1458, 2018 | 72 | 2018 |
| Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome L Ripaud, V Chumakova, M Antonin, AR Hastie, S Pinkert, R Körner, ... Proceedings of the National Academy of Sciences 111 (51), 18219-18224, 2014 | 64 | 2014 |
| Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins X Zeng, KM Ruff, RV Pappu Proceedings of the National Academy of Sciences 119 (19), e2200559119, 2022 | 56 | 2022 |
| Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient MR King, KM Ruff, AZ Lin, A Pant, M Farag, JM Lalmansingh, T Wu, ... Cell 187 (8), 1889-1906. e24, 2024 | 49 | 2024 |
| Polyphasic linkage and the impact of ligand binding on the regulation of biomolecular condensates KM Ruff, F Dar, RV Pappu Biophysics Reviews 2 (2), 021302, 2021 | 48 | 2021 |
| A Coarse-Grained Model for Polyglutamine Aggregation Modulated by Amphipathic Flanking Sequences KM Ruff, SJ Khan, RV Pappu Biophysical Journal 107 (5), 1226-1235, 2014 | 39 | 2014 |
