Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties NC Yip, IS Fombon, P Liu, S Brown, V Kannappan, AL Armesilla, B Xu, ... British journal of cancer 104 (10), 1564-1574, 2011 | 461 | 2011 |
Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells P Liu, S Brown, T Goktug, P Channathodiyil, V Kannappan, JP Hugnot, ... British journal of cancer 107 (9), 1488-1497, 2012 | 341 | 2012 |
Disulfiram‐mediated inhibition of NF‐κB activity enhances cytotoxicity of 5‐fluorouracil in human colorectal cancer cell lines W Wang, HL McLeod, J Cassidy International journal of cancer 104 (4), 504-511, 2003 | 301 | 2003 |
Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells P Liu, IS Kumar, S Brown, V Kannappan, PE Tawari, JZ Tang, W Jiang, ... British journal of cancer 109 (7), 1876-1885, 2013 | 212 | 2013 |
ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma L Yang, Y Ren, X Yu, F Qian, BSJ Bian, H Xiao, W Wang, S Xu, J Yang, ... Modern Pathology 27 (5), 775-783, 2014 | 165 | 2014 |
Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines X Guo, B Xu, S Pandey, E Goessl, J Brown, AL Armesilla, JL Darling, ... Cancer letters 290 (1), 104-113, 2010 | 164 | 2010 |
Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells W Wang, J Cassidy, V O’Brien, KM Ryan, E Collie-Duguid Cancer research 64 (22), 8167-8176, 2004 | 148 | 2004 |
Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo P Liu, Z Wang, S Brown, V Kannappan, PE Tawari, W Jiang, JM Irache, ... Oncotarget 5 (17), 7471, 2014 | 137 | 2014 |
Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2 B Xu, S Wang, R Li, K Chen, L He, M Deng, V Kannappan, J Zha, H Dong, ... Cell death & disease 8 (5), e2797-e2797, 2017 | 136 | 2017 |
Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition J Zha, F Chen, H Dong, P Shi, Y Yao, Y Zhang, R Li, S Wang, P Li, ... Journal of translational medicine 12, 1-9, 2014 | 115 | 2014 |
The cytotoxic mechanisms of disulfiram and copper (ii) in cancer cells PE Tawari, Z Wang, M Najlah, CW Tsang, V Kannappan, P Liu, ... Toxicology research 4 (6), 1439-1442, 2015 | 101 | 2015 |
Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells Z Wang, J Tan, C McConville, V Kannappan, PE Tawari, J Brown, J Ding, ... Nanomedicine: Nanotechnology, Biology and Medicine 13 (2), 641-657, 2017 | 100 | 2017 |
Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors W Wang, S Marsh, J Cassidy, HL McLeod Cancer research 61 (14), 5505-5510, 2001 | 99 | 2001 |
Recent advances in repurposing disulfiram and disulfiram derivatives as copper-dependent anticancer agents V Kannappan, M Ali, B Small, G Rajendran, S Elzhenni, H Taj, W Wang, ... Frontiers in Molecular Biosciences 8, 741316, 2021 | 98 | 2021 |
Insulin-like growth factor II and PAX3-FKHR cooperate in the oncogenesis of rhabdomyosarcoma W Wang, P Kumar, W Wang, J Epstein, L Helman, JV Moore, S Kumar Cancer research 58 (19), 4426-4433, 1998 | 90 | 1998 |
Development of injectable PEGylated liposome encapsulating disulfiram for colorectal cancer treatment M Najlah, A Said Suliman, I Tolaymat, S Kurusamy, V Kannappan, ... Pharmaceutics 11 (11), 610, 2019 | 83 | 2019 |
Cell cycle perturbation and acquired 5-fluorouracil chemoresistance X Guo, E Goessl, G Jin, ESR Collie-Duguid, J Cassidy, W Wang, ... Anticancer research 28 (1A), 9-14, 2008 | 80 | 2008 |
Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer M Najlah, Z Ahmed, M Iqbal, Z Wang, P Tawari, W Wang, C McConville European Journal of Pharmaceutics and Biopharmaceutics 112, 224-233, 2017 | 74 | 2017 |
A new strategy to target acute myeloid leukemia stem and progenitor cells using chidamide, a histone deacetylase inhibitor Y Li, K Chen, Y Zhou, Y Xiao, M Deng, Z Jiang, W Ye, X Wang, X Wei, J Li, ... Current cancer drug targets 15 (6), 493-503, 2015 | 73 | 2015 |
Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors Y Liu, F Chen, S Wang, X Guo, P Shi, W Wang, B Xu Cell death & disease 4 (12), e948-e948, 2013 | 72 | 2013 |