| A menin-MLL inhibitor induces specific chromatin changes and eradicates disease in models of MLL-rearranged leukemia AV Krivtsov, K Evans, JY Gadrey, BK Eschle, C Hatton, HJ Uckelmann, ... Cancer cell 36 (6), 660-673. e11, 2019 | 345 | 2019 |
| The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia GC Issa, I Aldoss, J DiPersio, B Cuglievan, R Stone, M Arellano, ... Nature 615 (7954), 920-924, 2023 | 275 | 2023 |
| Roles of JAK2 in aging, inflammation, hematopoiesis and malignant transformation F Perner, C Perner, T Ernst, FH Heidel Cells 8 (8), 854, 2019 | 207 | 2019 |
| Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms AK Jayavelu, TM Schnöder, F Perner, C Herzog, A Meiler, ... Nature 588 (7836), 157-163, 2020 | 126 | 2020 |
| MEN1 mutations mediate clinical resistance to menin inhibition F Perner, EM Stein, DV Wenge, S Singh, J Kim, A Apazidis, ... Nature 615 (7954), 913-919, 2023 | 113 | 2023 |
| The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML EB Heikamp, JA Henrich, F Perner, EM Wong, C Hatton, Y Wen, ... Blood, The Journal of the American Society of Hematology 139 (6), 894-906, 2022 | 111 | 2022 |
| Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia HJ Uckelmann, EL Haarer, R Takeda, EM Wong, C Hatton, C Marinaccio, ... Cancer discovery 13 (3), 746-765, 2023 | 73 | 2023 |
| Prevalence and dynamics of clonal hematopoiesis caused by leukemia-associated mutations in elderly individuals without hematologic disorders D Midic, J Rinke, F Perner, V Müller, A Hinze, F Pester, J Landschulze, ... Leukemia 34 (8), 2198-2205, 2020 | 48 | 2020 |
| Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease C Perner, F Perner, N Gaur, S Zimmermann, OW Witte, FH Heidel, ... Journal of neuroinflammation 16, 1-5, 2019 | 46 | 2019 |
| MLL:: AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape SN Olsen, L Godfrey, JP Healy, YA Choi, Y Kai, C Hatton, F Perner, ... Molecular cell 82 (6), 1140-1155. e11, 2022 | 43 | 2022 |
| Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts F Perner, JY Gadrey, Y Xiong, C Hatton, BK Eschle, A Weiss, F Stauffer, ... Blood, The Journal of the American Society of Hematology 136 (17), 1983-1988, 2020 | 41 | 2020 |
| The acetyltransferase GCN5 maintains ATRA-resistance in non-APL AML M Kahl, A Brioli, M Bens, F Perner, A Kresinsky, U Schnetzke, A Hinze, ... Leukemia 33 (11), 2628-2639, 2019 | 38 | 2019 |
| A molecular switch between mammalian MLL complexes dictates response to Menin–MLL inhibition YM Soto-Feliciano, FJ Sánchez-Rivera, F Perner, DW Barrows, ... Cancer discovery 13 (1), 146-169, 2023 | 35 | 2023 |
| IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia BJ Aubrey, JA Cutler, W Bourgeois, KA Donovan, S Gu, C Hatton, ... Nature cancer 3 (5), 595-613, 2022 | 34 | 2022 |
| YBX1 mediates translation of oncogenic transcripts to control cell competition in AML F Perner, TM Schnoeder, Y Xiong, AK Jayavelu, N Mashamba, ... Leukemia 36 (2), 426-437, 2022 | 30 | 2022 |
| Specificity of JAK-kinase inhibition determines impact on human and murine T-cell function F Perner, TM Schnöder, S Ranjan, D Wolleschak, C Ebert, MC Pils, S Frey, ... Leukemia 30 (4), 991-995, 2016 | 26 | 2016 |
| Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis PG Miller, AS Sperling, CJ Gibson, K Viswanathan, C Castellano, ... Blood, The Journal of the American Society of Hematology 136 (26), 3051-3055, 2020 | 25 | 2020 |
| Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients C Perner, F Perner, B Stubendorff, M Förster, OW Witte, FH Heidel, T Prell, ... Journal of Neuroinflammation 15, 1-5, 2018 | 25 | 2018 |
| Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function D Wolleschak, TS Mack, F Perner, S Frey, TM Schnöder, MC Wagner, ... Haematologica 99 (6), e90, 2014 | 23 | 2014 |
| The cell fate determinant Scribble is required for maintenance of hematopoietic stem cell function J Mohr, BP Dash, TM Schnoeder, D Wolleschak, C Herzog, ... Leukemia 32 (5), 1211-1221, 2018 | 22 | 2018 |