Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity MC Smith, JE Gestwicki Expert reviews in molecular medicine 14, 2012 | 332 | 2012 |
The E3 Ubiquitin Ligase CHIP and the Molecular Chaperone Hsc70 Form a Dynamic, Tethered Complex MC Smith, KM Scaglione, VA Assimon, S Patury, AD Thompson, ... Biochemistry 52 (32), 5354-5364, 2013 | 70 | 2013 |
Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes GM Walter, MC Smith, S Wisén, V Basrur, KSJ Elenitoba-Johnson, ... Journal of Biological Chemistry 286 (47), 40486-40493, 2011 | 34 | 2011 |
Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction CG Evans, MC Smith, JP Carolan, JE Gestwicki Bioorganic & medicinal chemistry letters 21 (9), 2587-2590, 2011 | 22 | 2011 |
Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction CG Evans, MC Smith, JP Carolan, JE Gestwicki Bioorganic & medicinal chemistry letters 21 (9), 2587-2590, 2011 | 22 | 2011 |
High‐Throughput Screen of Natural Product Extracts in A Yeast Model of Polyglutamine Proteotoxicity GM Walter, A Raveh, SA Mok, TJ McQuade, CJ Arevang, PJ Schultz, ... Chemical biology & drug design 83 (4), 440-449, 2014 | 20 | 2014 |
Inhibiting Protein-Protein Interactions in the Hsp70 Complex as a Means to Regulate Protein Homeostasis MC Smith University of Michigan, 2012 | 1 | 2012 |
Spergualin analogs as inhibitors of Hsp70-CHIP protein-protein interactions M Smith, V Assimon, CG Evans, JP Carolan, JE Gestwicki The FASEB Journal 26 (1 Supplement), lb106-lb106, 2012 | | 2012 |
Recent advances in medicinal chemistry BSJ Blagg, DS Johnson, RM Garbaccio, CG Evans, MC Smith, ... Bioorganic and Medicinal Chemistry Letters 21 (9), 2585, 2011 | | 2011 |