| S100A8/A9 drives the formation of procoagulant platelets through GPIbα M Colicchia, WC Schrottmaier, G Perrella, JS Reyat, J Begum, A Slater, ... Blood, The Journal of the American Society of Hematology 140 (24), 2626-2643, 2022 | 52 | 2022 |
| Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition P Billiald, A Slater, M Welin, JC Clark, S Loyau, M Pugnière, IG Jiacomini, ... Blood Advances 7 (7), 1258-1268, 2023 | 30 | 2023 |
| Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer A Slater, Y Di, JC Clark, NJ Jooss, EM Martin, F Alenazy, MR Thomas, ... Blood, The Journal of the American Society of Hematology 137 (24), 3443-3453, 2021 | 30 | 2021 |
| Evidence that GPVI is expressed as a mixture of monomers and dimers, and that the D2 domain is not essential for GPVI activation JC Clark, RAI Neagoe, M Zuidscherwoude, DM Kavanagh, A Slater, ... Thrombosis and Haemostasis 121 (11), 1435-1447, 2021 | 27 | 2021 |
| Adenosine and forskolin inhibit platelet aggregation by collagen but not the proximal signalling events JC Clark, DM Kavanagh, S Watson, JA Pike, RK Andrews, EE Gardiner, ... Thrombosis and Haemostasis 119 (07), 1124-1137, 2019 | 23 | 2019 |
| Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer? JC Clark, FN Damaskinaki, YFH Cheung, A Slater, SP Watson Platelets 32 (6), 724-732, 2021 | 20 | 2021 |
| Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins Z Maqsood, JC Clark, EM Martin, YFH Cheung, LA Morán, SET Watson, ... PLOS Computational Biology 18 (11), e1010708, 2022 | 8 | 2022 |
| Katacine is a new ligand of CLEC-2 that acts as a platelet agonist LA Morán, Y Di, MA Sowa, L Hermida-Nogueira, MN Barrachina, E Martin, ... Thrombosis and haemostasis 122 (08), 1361-1368, 2022 | 8 | 2022 |
| Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists JC Clark, EM Martin, LA Morán, Y Di, X Wang, M Zuidscherwoude, ... Communications Biology 6 (1), 376, 2023 | 7 | 2023 |
| Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+ D2 is independent of … FN Damaskinaki, NJ Jooss, EM Martin, JC Clark, MR Thomas, NS Poulter, ... Journal of Thrombosis and Haemostasis 21 (2), 317-328, 2023 | 5 | 2023 |
| Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2, and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand EM Martin, JC Clark, SJ Montague, LA Morán, Y Di, LJ Bull, L Whittle, ... Journal of Thrombosis and Haemostasis 22 (1), 271-285, 2024 | 3 | 2024 |
| Corrigendum to ‘Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand … EM Martin, JC Clark, SJ Montague, LA Morán, Y Di, LJ Bull, L Whittle, ... Journal of Thrombosis and Haemostasis 22 (8), 2378-2379, 2024 | | 2024 |
| PB0397 Differential Requirement for Ligand Valency in the Activation of CLEC-2 in Human and Humanised Mouse Platelets J Clark, E Martin, L Moran, Y Di, H Brown, B Nieswandt, D Stegner, ... Research and Practice in Thrombosis and Haemostasis 7, 2023 | | 2023 |
| Pharmacological Sciences OPEN ACCESS JC Clark, SP Watson, DM Owen Trends in Pharmacological Sciences 44 (10), 643, 2023 | | 2023 |
| Validation of agent-based models of surface receptor oligomerisation JC Clark, SP Watson, DM Owen Trends in Pharmacological Sciences, 2023 | | 2023 |
| The role of dimerisation in the activation of platelets by the collagen receptor GPVI JC Clark University of Birmingham, 2021 | | 2021 |
| This is a repository copy of Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer. A Slater, Y Di, JC Clark | | 2021 |
| Targeting platelet GPVI with glenzocimab P Billiald, A Slater, M Welin, J Clark, S Loyau, M Pugnière, IG Jiacomini, ... | | |
| Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor JC Clark, FN Damaskinaki, YFH Cheung, A Slater, SP Watson | | |
