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David C. Leitch
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The evolution of high-throughput experimentation in pharmaceutical development and perspectives on the future
SM Mennen, C Alhambra, CL Allen, M Barberis, S Berritt, TA Brandt, ...
Organic Process Research & Development 23 (6), 1213-1242, 2019
4202019
Chiral neutral zirconium amidate complexes for the asymmetric hydroamination of alkenes
MC Wood, DC Leitch, CS Yeung, JA Kozak, LL Schafer
Angewandte Chemie International Edition 46 (3), 354-358, 2007
3652007
Intramolecular Hydroamination of Unactived Olefins with Ti(NMe2)4 as a Precatalyst
JA Bexrud, JD Beard, DC Leitch, LL Schafer
Organic Letters 7 (10), 1959-1962, 2005
2552005
Broadening the scope of group 4 hydroamination catalysis using a tethered ureate ligand
DC Leitch, PR Payne, CR Dunbar, LL Schafer
Journal of the American Chemical Society 131 (51), 18246-18247, 2009
2032009
Selective C− H activation α to primary amines. Bridging metallaaziridines for catalytic, intramolecular α-alkylation
JA Bexrud, P Eisenberger, DC Leitch, PR Payne, LL Schafer
Journal of the American Chemical Society 131 (6), 2116-2118, 2009
2012009
An Easy‐To‐Use, Regioselective, and Robust Bis (amidate) Titanium Hydroamination Precatalyst: Mechanistic and Synthetic Investigations toward the Preparation of …
Z Zhang, DC Leitch, M Lu, BO Patrick, LL Schafer
Chemistry–A European Journal 13 (7), 2012-2022, 2007
1372007
Beyond bioisosteres: divergent synthesis of azabicyclohexanes and cyclobutenyl amines from bicyclobutanes
K Dhake, KJ Woelk, J Becica, A Un, SE Jenny, DC Leitch
Angewandte Chemie 134 (27), e202204719, 2022
1282022
Mechanistic Elucidation of Intramolecular Aminoalkene Hydroamination Catalyzed by a Tethered Bis (ureate) Complex: Evidence for Proton-Assisted C–N Bond Formation at Zirconium
DC Leitch, RH Platel, LL Schafer
Journal of the American Chemical Society 133 (39), 15453-15463, 2011
1082011
Bis (amidate) bis (amido) titanium complex: a regioselective intermolecular alkyne hydroamination catalyst
JCH Yim, JA Bexrud, RO Ayinla, DC Leitch, LL Schafer
The Journal of Organic Chemistry 79 (5), 2015-2028, 2014
1042014
The power and accessibility of high-throughput methods for catalysis research
CL Allen, DC Leitch, MS Anson, MA Zajac
Nature Catalysis 2 (1), 2-4, 2019
962019
Upgrading light hydrocarbons via tandem catalysis: a dual homogeneous Ta/Ir system for alkane/alkene coupling
DC Leitch, YC Lam, JA Labinger, JE Bercaw
Journal of the American Chemical Society 135 (28), 10302-10305, 2013
752013
A palladium-catalysed multicomponent coupling approach to conjugated poly (1, 3-dipoles) and polyheterocycles
DC Leitch, LV Kayser, ZY Han, AR Siamaki, EN Keyzer, A Gefen, ...
Nature Communications 6 (1), 7411, 2015
722015
Mechanistic Insight Enables Practical, Scalable, Room Temperature Chan–Lam N-Arylation of N-Aryl Sulfonamides
JC Vantourout, L Li, E Bendito-Moll, S Chabbra, K Arrington, BE Bode, ...
ACS Catalysis 8 (10), 9560-9566, 2018
692018
Isolation of catalytic intermediates in hydroamination reactions: insertion of internal alkynes into a zirconium–amido bond
DC Leitch, CS Turner, LL Schafer
Angewandte Chemie International Edition 49 (36), 6382-6386, 2010
692010
A reactivity model for oxidative addition to palladium enables quantitative predictions for catalytic cross-coupling reactions
J Lu, S Donnecke, I Paci, DC Leitch
Chemical Science 13 (12), 3477-3488, 2022
452022
Development and Cycloaddition Reactivity of a New Class of Pyridine‐Based Mesoionic 1, 3‐Dipole
H Erguven, DC Leitch, EN Keyzer, BA Arndtsen
Angewandte Chemie 129 (22), 6174-6178, 2017
422017
DMPDAB–Pd–MAH: A Versatile Pd(0) Source for Precatalyst Formation, Reaction Screening, and Preparative-Scale Synthesis
J Huang, M Isaac, R Watt, J Becica, E Dennis, MI Saidaminov, ...
ACS Catalysis 11 (9), 5636-5646, 2021
412021
Convergent synthesis of the NS5B inhibitor GSK8175 enabled by transition metal catalysis
K Arrington, GA Barcan, NA Calandra, GA Erickson, L Li, L Liu, MG Nilson, ...
The Journal of Organic Chemistry 84 (8), 4680-4694, 2018
372018
Development and scale-up of continuous electrocatalytic hydrogenation of functionalized nitro arenes, nitriles, and unsaturated aldehydes
JD Egbert, EC Thomsen, SA O’Neill-Slawecki, DM Mans, DC Leitch, ...
Organic Process Research & Development 23 (9), 1803-1812, 2019
352019
N, O‐Chelates of Group 4 Metals: Contrasting the Use of Amidates and Ureates in the Synthesis of Metal Dichlorides
DC Leitch, JD Beard, RK Thomson, VA Wright, BO Patrick, LL Schafer
European Journal of Inorganic Chemistry 2009 (18), 2691-2701, 2009
352009
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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