| Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli BW Biggs, CG Lim, K Sagliani, S Shankar, G Stephanopoulos, M De Mey, ... Proceedings of the National Academy of Sciences 113 (12), 3209-3214, 2016 | 239 | 2016 |
| Multivariate modular metabolic engineering for pathway and strain optimization BW Biggs, B De Paepe, CNS Santos, M De Mey, PK Ajikumar Current opinion in biotechnology 29, 156-162, 2014 | 158 | 2014 |
| Engineered bidirectional promoters enable rapid multi-gene co-expression optimization T Vogl, T Kickenweiz, J Pitzer, L Sturmberger, A Weninger, BW Biggs, ... Nature Communications 9 (1), 3589, 2018 | 116 | 2018 |
| Development of a genetic toolset for the highly engineerable and metabolically versatile Acinetobacter baylyi ADP1 BW Biggs, SR Bedore, E Arvay, S Huang, H Subramanian, EA McIntyre, ... Nucleic Acids Research 48 (9), 5169-5182, 2020 | 47 | 2020 |
| Predicting novel substrates for enzymes with minimal experimental effort with active learning DA Pertusi, ME Moura, JG Jeffryes, S Prabhu, BW Biggs, KEJ Tyo Metabolic engineering 44, 171-181, 2017 | 46 | 2017 |
| Orthogonal assays clarify the oxidative biochemistry of Taxol P450 CYP725A4 BW Biggs, JE Rouck, A Kambalyal, W Arnold, CG Lim, M De Mey, ... ACS chemical biology 11 (5), 1445-1451, 2016 | 42 | 2016 |
| Dynamic control of gene expression with riboregulated switchable feedback promoters CJ Glasscock, BW Biggs, JT Lazar, JH Arnold, LA Burdette, A Valdes, ... ACS synthetic biology 10 (5), 1199-1213, 2021 | 28* | 2021 |
| Engineering Acinetobacter baylyi ADP1 for mevalonate production from lignin-derived aromatic compounds E Arvay, BW Biggs, L Guerrero, V Jiang, K Tyo Metabolic engineering communications 13, e00173, 2021 | 27 | 2021 |
| Heterologous expression and characterization of plant Taxadiene-5α-Hydroxylase (CYP725A4) in Escherichia coli JE Rouck, BW Biggs, A Kambalyal, WR Arnold, M De Mey, PK Ajikumar, ... Protein expression and purification 132, 60-67, 2017 | 21 | 2017 |
| Enabling commercial success of industrial biotechnology BW Biggs, HS Alper, BF Pfleger, KEJ Tyo, CNS Santos, PK Ajikumar, ... Science 374 (6575), 1563-1565, 2021 | 18 | 2021 |
| Selective patterning of Si-based biosensor surfaces using isotropic silicon etchants BW Biggs, HK Hunt, AM Armani Journal of colloid and interface science 369 (1), 477-481, 2012 | 15 | 2012 |
| Improving the specificity and stability of label-free optical biosensors AM Armani, HK Hunt, CE Soteropulos, B Biggs, R Hawk IEEE Photonic Society 24th Annual Meeting, 417-418, 2011 | 3 | 2011 |
| High-throughput protein characterization by complementation using DNA barcoded fragment libraries BW Biggs, MN Price, D Lai, J Escobedo, Y Fortanel, YY Huang, K Kim, ... Molecular Systems Biology 20 (11), 1207-1229, 2024 | 2 | 2024 |
| Aromatic natural products synthesis from aromatic lignin monomers using Acinetobacter baylyi ADP1 BW Biggs, KEJ Tyo bioRxiv, 2023 | 2 | 2023 |
| Riboregulated Switchable Feedback Promoter Systems and Methods CJ Glasscock, JB Lucks, DT Ercek, K Tyo, BW Biggs US Patent App. 17/202,202, 2021 | 2 | 2021 |
| Chemically inducible chromosomal evolution (ciche) for multicopy metabolic pathway engineering AM Love, BW Biggs, KEJ Tyo, PK Ajikumar Microbial Metabolic Engineering: Methods and Protocols, 37-45, 2019 | 2 | 2019 |
| Genomic Fragment Library Generation (Coaux-Seq) B Biggs, AM Deutschbauer, A Arkin | | 2024 |
| Complementation, Selection Assays (Coaux-Seq) B Biggs, AM Deutschbauer, A Arkin | | 2024 |
| High-throughput protein characterization by complementation using DNA barcoded BW Biggs, MN Price, D Lai | | 2024 |
| Assaying for Realized Niche Expansion in Stressed Environments with Synthetic Microbial Communities B Biggs, M Datta, I Raza, M de Raad, T Northen, AP Arkin 2023 AIChE Annual Meeting, 2023 | | 2023 |
Keith TyoAssociate Professor of Chemical and Biological Engineering, Northwestern UniversityEmail verificata su northwestern.edu
