| Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin T Hirano, K Yasukawa, H Harada, T Taga, Y Watanabe, T Matsuda, ... Nature 324 (6092), 73-76, 1986 | 2909 | 1986 |
| Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas M Kawano, T Hirano, T Matsuda, T Taga, Y Horii, K Iwato, H Asaoku, ... Nature 332 (6159), 83-85, 1988 | 2144 | 1988 |
| Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 T Taga, M Hibi, Y Hirata, K Yamasaki, K Yasukawa, T Matsuda, T Hirano, ... Cell 58 (3), 573-581, 1989 | 1909 | 1989 |
| A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family. S Akira, H Isshiki, T Sugita, O Tanabe, S Kinoshita, Y Nishio, T Nakajima, ... The EMBO journal 9 (6), 1897-1906, 1990 | 1891 | 1990 |
| Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF) S Akira, T Hirano, T Taga, T Kishimoto The FASEB journal 4 (11), 2860-2867, 1990 | 1794 | 1990 |
| Molecular cloning and expression of an IL-6 signal transducer, gp130 M Hibi, M Murakami, M Saito, T Hirano, T Taga, T Kishimoto Cell 63 (6), 1149-1157, 1990 | 1716 | 1990 |
| Biological and clinical aspects of interleukin 6 T Hirano, S Akira, T Taga, T Kishimoto Immunology today 11, 443-449, 1990 | 1583 | 1990 |
| Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors T Hirano, K Ishihara, M Hibi Oncogene 19 (21), 2548-2556, 2000 | 1565 | 2000 |
| Cloning and expression of the human interleukin-6 (BSF-2/IFNβ 2) receptor K Yamasaki, T Taga, Y Hirata, H Yawata, Y Kawanishi, B Seed, ... Science 241 (4867), 825-828, 1988 | 1507 | 1988 |
| IL-6 is produced by osteoblasts and induces bone resorption. Y Ishimi, C Miyaura, CH Jin, T Akatsu, E Abe, Y Nakamura, A Yamaguchi, ... Journal of Immunology (Baltimore, Md.: 1950) 145 (10), 3297-3303, 1990 | 1474 | 1990 |
| Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease K Yoshizaki, T Matsuda, N Nishimoto, T Kuritani, L Taeho, K Aozasa, ... | 1201 | 1989 |
| IL-6 in autoimmune disease and chronic inflammatory proliferative disease K Ishihara, T Hirano Cytokine & growth factor reviews 13 (4-5), 357-368, 2002 | 1133 | 2002 |
| The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. A Muraguchi, T Hirano, BO Tang, T Matsuda, Y Horii, K Nakajima, ... The Journal of experimental medicine 167 (2), 332-344, 1988 | 1085 | 1988 |
| Interleukin 6 and its receptor: ten years later T Hirano International reviews of immunology 16 (3-4), 249-284, 1998 | 1060 | 1998 |
| Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis T Hirano, T Matsuda, M Turner, N Miyasaka, G Buchan, B Tang, K Sato, ... European journal of immunology 18 (11), 1797-1802, 1988 | 1043 | 1988 |
| Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). T Hirano, T Taga, N Nakano, K Yasukawa, S Kashiwamura, K Shimizu, ... Proceedings of the National Academy of Sciences 82 (16), 5490-5494, 1985 | 1007 | 1985 |
| IL-6 in inflammation, autoimmunity and cancer T Hirano International immunology 33 (3), 127-148, 2021 | 959 | 2021 |
| IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages H Yasukawa, M Ohishi, H Mori, M Murakami, T Chinen, D Aki, T Hanada, ... Nature immunology 4 (6), 551-556, 2003 | 955 | 2003 |
| IL-6 signal transduction and its physiological roles: the signal orchestration model D Kamimura, K Ishihara, T Hirano Reviews of physiology, biochemistry and pharmacology, 1-38, 2004 | 931 | 2004 |
| COVID-19: a new virus, but a familiar receptor and cytokine release syndrome T Hirano, M Murakami Immunity 52 (5), 731-733, 2020 | 870 | 2020 |
