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Pascal Devant
Pascal Devant
Harvard Medical School
Email verificata su g.harvard.edu
Titolo
Citata da
Citata da
Anno
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
CL Evavold, I Hafner-Bratkovič, P Devant, JM D’Andrea, EM Ngwa, ...
Cell 184 (17), 4495-4511. e19, 2021
3222021
Molecular mechanisms of gasdermin D pore-forming activity
P Devant, JC Kagan
Nature Immunology 24 (7), 1064-1075, 2023
1152023
Gasdermin D pore-forming activity is redox-sensitive
P Devant, E Boršić, EM Ngwa, H Xiao, ET Chouchani, JR Thiagarajah, ...
Cell reports 42 (1), 2023
732023
Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
JP Borges, RSR Sætra, A Volchuk, M Bugge, P Devant, B Sporsheim, ...
Elife 11, e78609, 2022
632022
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis
A Balasubramanian, AY Hsu, L Ghimire, M Tahir, P Devant, P Fontana, ...
Science immunology 9 (94), eadn1452, 2024
602024
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D
G Du, LB Healy, L David, C Walker, TJ El-Baba, CA Lutomski, B Goh, ...
Nature, 1-3, 2024
532024
Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia
S Sekulovski, P Devant, S Panizza, T Gogakos, A Pitiriciu, K Heitmeier, ...
Nature communications 12 (1), 5610, 2021
372021
Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β–converting enzyme
P Devant, A Cao, JC Kagan
Science immunology 6 (62), eabh3567, 2021
342021
Structural insights into cytokine cleavage by inflammatory caspase-4
P Devant, Y Dong, J Mintseris, W Ma, SP Gygi, H Wu, JC Kagan
Nature 624 (7991), 451-459, 2023
312023
ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation
G Du, LB Healy, L David, C Walker, P Fontana, Y Dong, P Devant, ...
BioRxiv, 2023.03. 07.531538, 2023
272023
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors
D Zhivaki, SN Kennedy, J Park, F Boriello, P Devant, A Cao, KM Bahleda, ...
Cell, 2024
122024
Structural transitions enable interleukin-18 maturation and signaling
Y Dong, JP Bonin, P Devant, Z Liang, AIM Sever, J Mintseris, JM Aramini, ...
Immunity, 2024
72024
Engineering an antibody V gene-selective vaccine
L Ronsard, AS Yousif, J Peabody, V Okonkwo, P Devant, AT Mogus, ...
Frontiers in immunology 12, 730471, 2021
72021
The pore-forming protein gasdermin D is a cellular redox sensor
P Devant, E Boršić, EM Ngwa, JR Thiagarajah, I Hafner-Bratkovič, ...
bioRxiv, 2022.03. 11.484021, 2022
52022
Protocol to purify recombinant inflammatory caspases and assess their catalytic activity in vitro
P Devant, JC Kagan
STAR protocols 3 (4), 101848, 2022
32022
Evolution-inspired dissection of caspase activities enables the redesign of caspase-4 into an LPS sensing interleukin-1 converting enzyme
P Devant, A Cao, JC Kagan
bioRxiv, 2020.12. 07.413732, 2020
32020
LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules
AB Cao, P Devant, C Wang, M Sun, SN Kennedy, J Ruan, JC Kagan
bioRxiv, 2024
2024
Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4
P Devant, Y Dong, J Mintseris, W Ma, SP Gygi, H Wu, JC Kagan
Nature 625 (7995), E17-E17, 2024
2024
Molecular and Evolutionary Aspects of Inflammatory Caspase-Mediated Innate Immunity
PM Devant
Harvard University, 2024
2024
Regulating the unregulated: what host factors are required for GSDMD pore formation?
CL Evavold, I Hafner-Bratkovic, P Devant, JC Kagan
The Journal of Immunology 206 (1_Supplement), 111.06-111.06, 2021
2021
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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