| Multiplex genome engineering using CRISPR/Cas systems L Cong, FA Ran, D Cox, S Lin, R Barretto, N Habib, PD Hsu, X Wu, ... Science 339 (6121), 819-823, 2013 | 19178 | 2013 |
| DNA targeting specificity of RNA-guided Cas9 nucleases PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ... Nature biotechnology 31 (9), 827-832, 2013 | 5721 | 2013 |
| In vivo genome editing using Staphylococcus aureus Cas9 FA Ran, L Cong, WX Yan, DA Scott, JS Gootenberg, AJ Kriz, B Zetsche, ... Nature 520 (7546), 186-191, 2015 | 3210 | 2015 |
| Editing DNA methylation in the mammalian genome XS Liu, H Wu, X Ji, Y Stelzer, X Wu, S Czauderna, J Shu, D Dadon, ... Cell 167 (1), 233-247. e17, 2016 | 1335 | 2016 |
| Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells X Wu, S David, AJ Kriz, A Chiu, P Hsu, D Dadon, A Cheng, A Trevino, ... Nature Biotechnology, 2014 | 1215 | 2014 |
| Network‐based global inference of human disease genes X Wu, R Jiang, MQ Zhang, S Li Molecular systems biology 4 (1), 189, 2008 | 786 | 2008 |
| Rescue of fragile X syndrome neurons by DNA methylation editing of the FMR1 gene XS Liu, H Wu, M Krzisch, X Wu, J Graef, J Muffat, D Hnisz, CH Li, B Yuan, ... Cell 172 (5), 979-992. e6, 2018 | 508 | 2018 |
| Target specificity of the CRISPR-Cas9 system X Wu, A Kriz, P Sharp Quantitative Biology, 2014 | 444 | 2014 |
| Promoter directionality is controlled by U1 snRNP and polyadenylation signals AE Almada*, X Wu*, AJ Kriz, CB Burge, PA Sharp Nature 499 (7458), 360-363, 2013 | 444 | 2013 |
| Cell-type-specific alternative splicing governs cell fate in the developing cerebral cortex X Zhang, MH Chen, X Wu, A Kodani, J Fan, R Doan, M Ozawa, J Ma, ... Cell 166 (5), 1147-1162. e15, 2016 | 357 | 2016 |
| A random forest approach to the detection of epistatic interactions in case-control studies R Jiang, W Tang, X Wu, W Fu BMC bioinformatics 10, 1-12, 2009 | 357 | 2009 |
| Structural basis for the RNA-guided ribonuclease activity of CRISPR-Cas13d C Zhang, S Konermann, NJ Brideau, P Lotfy, X Wu, SJ Novick, ... Cell 175 (1), 212-223. e17, 2018 | 258 | 2018 |
| Single-molecule mRNA detection and counting in mammalian tissue A Lyubimova, S Itzkovitz, JP Junker, ZP Fan, X Wu, A Van Oudenaarden Nature protocols 8 (9), 1743-1758, 2013 | 224 | 2013 |
| Divergent transcription: a driving force for new gene origination X Wu, PA Sharp Cell 155 (5), 990-996, 2013 | 199 | 2013 |
| Widespread influence of 3′-end structures on mammalian mRNA processing and stability X Wu, D Bartel Cell 169, 905–917, 2017 | 151 | 2017 |
| Epistatic module detection for case-control studies: a Bayesian model with a Gibbs sampling strategy W Tang, X Wu, R Jiang, Y Li PLoS genetics 5 (5), e1000464, 2009 | 145 | 2009 |
| kpLogo: positional k-mer analysis reveals hidden specificity in biological sequences X Wu^, DP Bartel^ Nucleic Acids Research, gkx323, 2017 | 126 | 2017 |
| Transcriptional pause sites delineate stable nucleosome-associated premature polyadenylation suppressed by U1 snRNP AC Chiu, HI Suzuki, X Wu, DB Mahat, AJ Kriz, PA Sharp Molecular cell 69 (4), 648-663. e7, 2018 | 125 | 2018 |
| Align human interactome with phenome to identify causative genes and networks underlying disease families X Wu, Q Liu, R Jiang Bioinformatics 25 (1), 98-104, 2009 | 121 | 2009 |
| Global microRNA depletion suppresses tumor angiogenesis S Chen, Y Xue, X Wu, C Le, A Bhutkar, EL Bell, F Zhang, R Langer, ... Genes & development 28 (10), 1054-1067, 2014 | 101 | 2014 |
Rui JiangTsinghua UniversityEmail verificata su tsinghua.edu.cn
