| IDH mutation in glioma: molecular mechanisms and potential therapeutic targets S Han, Y Liu, SJ Cai, M Qian, J Ding, M Larion, MR Gilbert, C Yang British journal of cancer 122 (11), 1580-1589, 2020 | 561 | 2020 |
| Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells N Colwell, M Larion, AJ Giles, AN Seldomridge, S Sizdahkhani, ... Neuro-oncology 19 (7), 887-896, 2017 | 280 | 2017 |
| Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism D Yu, Y Liu, Y Zhou, V Ruiz-Rodado, M Larion, G Xu, C Yang Proceedings of the National Academy of Sciences 117 (18), 9964-9972, 2020 | 118 | 2020 |
| Targeting glycolysis through inhibition of lactate dehydrogenase impairs tumor growth in preclinical models of Ewing sarcoma C Yeung, AE Gibson, SH Issaq, N Oshima, JT Baumgart, LD Edessa, ... Cancer research 79 (19), 5060-5073, 2019 | 114 | 2019 |
| Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma L Ren, V Ruiz-Rodado, T Dowdy, S Huang, SH Issaq, J Beck, H Wang, ... Cancer & metabolism 8, 1-13, 2020 | 90 | 2020 |
| Order–disorder transitions govern kinetic cooperativity and allostery of monomeric human glucokinase M Larion, RK Salinas, L Bruschweiler-Li, BG Miller, R Brüschweiler PLoS biology 10 (12), e1001452, 2012 | 73 | 2012 |
| Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding MT Doyle, JR Jimah, T Dowdy, SI Ohlemacher, M Larion, JE Hinshaw, ... Cell 185 (7), 1143-1156. e13, 2022 | 72 | 2022 |
| Dual allosteric activation mechanisms in monomeric human glucokinase AC Whittington, M Larion, JM Bowler, KM Ramsey, R Brüschweiler, ... Proceedings of the National Academy of Sciences 112 (37), 11553-11558, 2015 | 68 | 2015 |
| IDH1 mutations induce organelle defects via dysregulated phospholipids A Lita, A Pliss, A Kuzmin, T Yamasaki, L Zhang, T Dowdy, C Burks, ... Nature Communications 12 (1), 614, 2021 | 60 | 2021 |
| Novel targeting of transcription and metabolism in glioblastoma YT Su, R Chen, H Wang, H Song, Q Zhang, LY Chen, H Lappin, ... Clinical Cancer Research 24 (5), 1124-1137, 2018 | 57 | 2018 |
| IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation A Mortazavi, I Fayed, M Bachani, T Dowdy, J Jahanipour, A Khan, ... Neuro-oncology 24 (9), 1423-1435, 2022 | 56 | 2022 |
| Homotropic allosteric regulation in monomeric mammalian glucokinase M Larion, BG Miller Archives of biochemistry and biophysics 519 (2), 103-111, 2012 | 56 | 2012 |
| T cell exhaustion in malignant gliomas MB Watowich, MR Gilbert, M Larion Trends in cancer 9 (4), 270-292, 2023 | 45 | 2023 |
| Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas V Ruiz-Rodado, TM Malta, T Seki, A Lita, T Dowdy, O Celiku, ... Neuro-oncology 22 (4), 480-492, 2020 | 41 | 2020 |
| Kinetic cooperativity in human pancreatic glucokinase originates from millisecond dynamics of the small domain M Larion, AL Hansen, F Zhang, L Bruschweiler‐Li, V Tugarinov, BG Miller, ... Angewandte Chemie 127 (28), 8247-8250, 2015 | 39 | 2015 |
| Advances in measuring cancer cell metabolism with subcellular resolution V Ruiz-Rodado, A Lita, M Larion Nature Methods 19 (9), 1048-1063, 2022 | 36 | 2022 |
| TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis T Gauthier, C Yao, T Dowdy, W Jin, YJ Lim, LC Patiño, N Liu, ... Science signaling 16 (797), eade0385, 2023 | 34 | 2023 |
| Direct evidence of conformational heterogeneity in human pancreatic glucokinase from high-resolution nuclear magnetic resonance M Larion, RK Salinas, L Bruschweiler-Li, R Brüschweiler, BG Miller Biochemistry 49 (37), 7969-7971, 2010 | 34 | 2010 |
| Detection of metabolic changes induced via drug treatments in live cancer cells and tissue using Raman imaging microscopy M Larion, T Dowdy, V Ruiz-Rodado, MW Meyer, H Song, W Zhang, ... Biosensors 9 (1), 5, 2018 | 31 | 2018 |
| Divergent evolution of function in the ROK sugar kinase superfamily: role of enzyme loops in substrate specificity M Larion, LB Moore, SM Thompson, BG Miller Biochemistry 46 (47), 13564-13572, 2007 | 31 | 2007 |
Roberto Kopke SalinasProfessor de Bioquímica, Universidade de São PauloEmail verificata su iq.usp.br