| ER stress triggers apoptosis by activating BH3-only protein Bim H Puthalakath, LA O'Reilly, P Gunn, L Lee, PN Kelly, ND Huntington, ... Cell 129 (7), 1337-1349, 2007 | 1709 | 2007 |
| p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa A Villunger, EM Michalak, L Coultas, F Mullauer, G Böck, ... Science 302 (5647), 1036-1038, 2003 | 1652 | 2003 |
| An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer ML Burr, CE Sparbier, KL Chan, YC Chan, A Kersbergen, EYN Lam, ... Cancer cell 36 (4), 385-401. e8, 2019 | 545 | 2019 |
| The roles of DNA, RNA and histone methylation in ageing and cancer EM Michalak, ML Burr, AJ Bannister, MA Dawson Nature reviews Molecular cell biology 20 (10), 573-589, 2019 | 478 | 2019 |
| BH3-only proteins Puma and Bim are rate-limiting for γ-radiation–and glucocorticoid-induced apoptosis of lymphoid cells in vivo M Erlacher, EM Michalak, PN Kelly, V Labi, H Niederegger, L Coultas, ... Blood 106 (13), 4131-4138, 2005 | 352 | 2005 |
| p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa LJ Valente, DHD Gray, EM Michalak, J Pinon-Hofbauer, A Egle, CL Scott, ... Cell reports 3 (5), 1339-1345, 2013 | 339 | 2013 |
| Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1 ND Huntington, H Puthalakath, P Gunn, E Naik, EM Michalak, MJ Smyth, ... Nature immunology 8 (8), 856-863, 2007 | 308 | 2007 |
| DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa JB Kerr, KJ Hutt, EM Michalak, M Cook, CJ Vandenberg, SH Liew, ... Molecular cell 48 (3), 343-352, 2012 | 286 | 2012 |
| Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction M Erlacher, V Labi, C Manzl, G Böck, A Tzankov, G Häcker, E Michalak, ... The Journal of experimental medicine 203 (13), 2939-2951, 2006 | 272 | 2006 |
| In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute EM Michalak, A Villunger, JM Adams, A Strasser Cell Death & Differentiation 15 (6), 1019-1029, 2008 | 252 | 2008 |
| Developmental stage‐specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland KE de Visser, M Ciampricotti, EM Michalak, DWM Tan, EN Speksnijder, ... The Journal of pathology 228 (3), 300-309, 2012 | 205 | 2012 |
| A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation EF Lee, PE Czabotar, MF Van Delft, EM Michalak, MJ Boyle, SN Willis, ... The Journal of cell biology 180 (2), 341-355, 2008 | 193 | 2008 |
| Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis EM Michalak, ES Jansen, L Happo, MS Cragg, L Tai, GK Smyth, ... Cell Death & Differentiation 16 (5), 684-696, 2009 | 189 | 2009 |
| Death squads enlisted by the tumour suppressor p53 E Michalak, A Villunger, M Erlacher, A Strasser Biochemical and biophysical research communications 331 (3), 786-798, 2005 | 164 | 2005 |
| Apoptosis-promoted tumorigenesis: γ-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death EM Michalak, CJ Vandenberg, ARD Delbridge, L Wu, CL Scott, JM Adams, ... Genes & development 24 (15), 1608-1613, 2010 | 148 | 2010 |
| Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa E Naik, EM Michalak, A Villunger, JM Adams, A Strasser The Journal of cell biology 176 (4), 415-424, 2007 | 148 | 2007 |
| Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer L Henneman, MH van Miltenburg, EM Michalak, TM Braumuller, ... Proceedings of the National Academy of Sciences 112 (27), 8409-8414, 2015 | 143 | 2015 |
| Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim L Happo, MS Cragg, B Phipson, JM Haga, ES Jansen, MJ Herold, ... Blood, The Journal of the American Society of Hematology 116 (24), 5256-5267, 2010 | 123 | 2010 |
| Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells IJ Huijbers, R Bin Ali, C Pritchard, M Cozijnsen, MC Kwon, N Proost, ... EMBO molecular medicine 6 (2), 212-225, 2014 | 93 | 2014 |
| Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma PG Ekert, AM Jabbour, A Manoharan, JE Heraud, J Yu, M Pakusch, ... Blood 108 (5), 1461-1468, 2006 | 91 | 2006 |