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| Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine EH Walker, ME Pacold, O Perisic, L Stephens, PT Hawkins, MP Wymann, ... Molecular cell 6 (4), 909-919, 2000 | 1556 | 2000 |
| Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. A Jacobo-Molina, J Ding, RG Nanni, AD Clark Jr, X Lu, C Tantillo, ... Proceedings of the National Academy of Sciences 90 (13), 6320-6324, 1993 | 1527 | 1993 |
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| The emerging shape of the ESCRT machinery RL Williams, S Urbé Nature reviews Molecular cell biology 8 (5), 355-368, 2007 | 933 | 2007 |
| Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ ME Pacold, S Suire, O Perisic, S Lara-Gonzalez, CT Davis, EH Walker, ... Cell 103 (6), 931-944, 2000 | 806 | 2000 |
| Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ LO Essen, O Perisic, R Cheung, M Katan, RL Williams Nature 380 (6575), 595-602, 1996 | 731 | 1996 |
| Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage I Angulo, O Vadas, F Garçon, E Banham-Hall, V Plagnol, TR Leahy, ... Science 342 (6160), 866-871, 2013 | 675 | 2013 |
| Structural insights into phosphoinositide 3-kinase catalysis and signalling EH Walker, O Perisic, C Ried, L Stephens, RL Williams Nature 402 (6759), 313-320, 1999 | 645 | 1999 |
| Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases B Apsel, JA Blair, B Gonzalez, TM Nazif, ME Feldman, B Aizenstein, ... Nature chemical biology 4 (11), 691, 2008 | 580 | 2008 |
| Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit N Miled, Y Yan, WC Hon, O Perisic, M Zvelebil, Y Inbar, ... science 317 (5835), 239-242, 2007 | 480 | 2007 |
| Binding of the PX domain of p47phox to phosphatidylinositol 3, 4‐bisphosphate and phosphatidic acid is masked by an intramolecular interaction D Karathanassis, RV Stahelin, J Bravo, O Perisic, CM Pacold, W Cho, ... The EMBO journal, 2002 | 387 | 2002 |
| A role for the ESCRT system in cell division in archaea RY Samson, T Obita, SM Freund, RL Williams, SD Bell Science 322 (5908), 1710-1713, 2008 | 383 | 2008 |
| The p110δ structure: mechanisms for selectivity and potency of new PI (3) K inhibitors A Berndt, S Miller, O Williams, DD Le, BT Houseman, JI Pacold, F Gorrec, ... Nature chemical biology 6 (2), 117-124, 2010 | 357 | 2010 |
| The crystal structure of the PX domain from p40phox bound to phosphatidylinositol 3-phosphate J Bravo, D Karathanassis, CM Pacold, ME Pacold, CD Ellson, ... Molecular cell 8 (4), 829-839, 2001 | 342 | 2001 |
| Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4 T Obita, S Saksena, S Ghazi-Tabatabai, DJ Gill, O Perisic, SD Emr, ... Nature 449 (7163), 735-739, 2007 | 340 | 2007 |
| Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2 O Perisic, S Fong, DE Lynch, M Bycroft, RL Williams Journal of Biological Chemistry 273 (3), 1596-1604, 1998 | 336 | 1998 |
| Structural basis for activation and inhibition of class I phosphoinositide 3-kinases O Vadas, JE Burke, X Zhang, A Berndt, RL Williams Science signaling 4 (195), re2-re2, 2011 | 327 | 2011 |
| ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes H Teo, DJ Gill, J Sun, O Perisic, DB Veprintsev, Y Vallis, SD Emr, ... Cell 125 (1), 99-111, 2006 | 320 | 2006 |
| Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA) JE Burke, O Perisic, GR Masson, O Vadas, RL Williams Proceedings of the National Academy of Sciences 109 (38), 15259-15264, 2012 | 312 | 2012 |
John E BurkeProfessor of Biochemistry and Microbiology, University of VictoriaEmail verificata su uvic.ca