| An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor X Zhang, J Gureasko, K Shen, PA Cole, J Kuriyan Cell 125 (6), 1137-1149, 2006 | 1929 | 2006 |
| Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING X Zhang, H Shi, J Wu, X Zhang, L Sun, C Chen, ZJ Chen Molecular cell 51 (2), 226-235, 2013 | 1093 | 2013 |
| Structural basis of STING binding with and phosphorylation by TBK1 C Zhang, G Shang, X Gui, X Zhang, X Bai, ZJ Chen Nature 567 (7748), 394-398, 2019 | 796 | 2019 |
| Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment N Jura, NF Endres, K Engel, S Deindl, R Das, MH Lamers, DE Wemmer, ... Cell 137 (7), 1293-1307, 2009 | 702 | 2009 |
| Structural and functional analysis of the costimulatory receptor programmed death-1 X Zhang, JCD Schwartz, X Guo, S Bhatia, E Cao, L Chen, ZY Zhang, ... Immunity 20 (3), 337-347, 2004 | 628 | 2004 |
| Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP G Shang, C Zhang, ZJ Chen, X Bai, X Zhang Nature 567 (7748), 389-393, 2019 | 579 | 2019 |
| Structures and mechanisms in the cGAS-STING innate immunity pathway X Zhang, X Bai, ZJ Chen Immunity 53 (1), 43-53, 2020 | 481 | 2020 |
| The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop X Zhang, J Wu, F Du, H Xu, L Sun, Z Chen, CA Brautigam, X Zhang, ... Cell reports 6 (3), 421-430, 2014 | 481 | 2014 |
| Structural basis for co-stimulation by the human CTLA-4/B7-2 complex JCD Schwartz, X Zhang, AA Fedorov, SG Nathenson, SC Almo Nature 410 (6828), 604-608, 2001 | 446 | 2001 |
| Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization Y Shan, MP Eastwood, X Zhang, ET Kim, A Arkhipov, RO Dror, J Jumper, ... Cell 149 (4), 860-870, 2012 | 418 | 2012 |
| Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface X Zhang, KA Pickin, R Bose, N Jura, PA Cole, J Kuriyan Nature 450 (7170), 741-744, 2007 | 402 | 2007 |
| Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms N Jura, X Zhang, NF Endres, MA Seeliger, T Schindler, J Kuriyan Molecular cell 42 (1), 9-22, 2011 | 345 | 2011 |
| Structural basis for the prion-like MAVS filaments in antiviral innate immunity H Xu, X He, H Zheng, L Huang, F Hou, Z Yu, MJ de la Cruz, B Borkowski, ... Biophysical Journal 106 (2), 684a, 2014 | 210 | 2014 |
| Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization Y Wang, H He, N Srivastava, S Vikarunnessa, Y Chen, J Jiang, ... Science's STKE 5 (207), ra6, 2012 | 185 | 2012 |
| Structural mechanisms of costimulation JCD Schwartz, X Zhang, SG Nathenson, SC Almo Nature immunology 3 (5), 427-434, 2002 | 170 | 2002 |
| Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling X Zhang, JCD Schwartz, SC Almo, SG Nathenson Proceedings of the National Academy of Sciences 100 (5), 2586-2591, 2003 | 126 | 2003 |
| Structural basis of the activation of c-MET receptor E Uchikawa, Z Chen, GY Xiao, X Zhang, X Bai Nature communications 12 (1), 4074, 2021 | 105 | 2021 |
| Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration H He, T Yang, JR Terman, X Zhang Proceedings of the National Academy of Sciences 106 (37), 15610-15615, 2009 | 104 | 2009 |
| Activation of STING by targeting a pocket in the transmembrane domain D Lu, G Shang, J Li, Y Lu, X Bai, X Zhang Nature 604 (7906), 557-562, 2022 | 101 | 2022 |
| The ErbB kinase domain: structural perspectives into kinase activation and inhibition R Bose, X Zhang Experimental cell research 315 (4), 649-658, 2009 | 97 | 2009 |
