| AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA T Fernandes-Alnemri, JW Yu, P Datta, J Wu, ES Alnemri Nature 458 (7237), 509-513, 2009 | 2134 | 2009 |
| The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation T Fernandes-Alnemri, J Wu, JW Yu, P Datta, B Miller, W Jankowski, ... Cell Death & Differentiation 14 (9), 1590-1604, 2007 | 1219 | 2007 |
| The AIM2 inflammasome is critical for innate immunity to Francisella tularensis T Fernandes-Alnemri, JW Yu, C Juliana, L Solorzano, S Kang, J Wu, ... Nature immunology 11 (5), 385-393, 2010 | 866 | 2010 |
| Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome C Juliana, T Fernandes-Alnemri, J Wu, P Datta, L Solorzano, JW Yu, ... Journal of Biological Chemistry 285 (13), 9792-9802, 2010 | 652 | 2010 |
| Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization JW Yu, J Wu, Z Zhang, P Datta, I Ibrahimi, S Taniguchi, J Sagara, ... Cell Death & Differentiation 13 (2), 236-249, 2006 | 464 | 2006 |
| Mutations in NALP12 cause hereditary periodic fever syndromes I Jeru, P Duquesnoy, T Fernandes-Alnemri, E Cochet, JW Yu, ... Proceedings of the National Academy of Sciences 105 (5), 1614-1619, 2008 | 441 | 2008 |
| SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease SR Kim, SG Lee, SH Kim, JH Kim, E Choi, W Cho, JH Rim, I Hwang, ... Nature communications 11 (1), 2127, 2020 | 402 | 2020 |
| MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration E Lee, I Hwang, S Park, S Hong, B Hwang, Y Cho, J Son, JW Yu Cell Death & Differentiation 26 (2), 213-228, 2019 | 370 | 2019 |
| Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants JW Yu, T Fernandes-Alnemri, P Datta, J Wu, C Juliana, L Solorzano, ... Molecular cell 28 (2), 214-227, 2007 | 339 | 2007 |
| The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity S Park, C Juliana, S Hong, P Datta, I Hwang, T Fernandes-Alnemri, JW Yu, ... The Journal of Immunology 191 (8), 4358-4366, 2013 | 286 | 2013 |
| Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance JW Yu, MS Lee Archives of pharmacal research 39, 1503-1518, 2016 | 187 | 2016 |
| Defective mitochondrial fission augments NLRP3 inflammasome activation S Park, JH Won, I Hwang, S Hong, HK Lee, JW Yu Scientific reports 5 (1), 15489, 2015 | 171 | 2015 |
| 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome J Jang, S Park, H Jin Hur, HJ Cho, I Hwang, Y Pyo Kang, I Im, H Lee, ... Nature communications 7 (1), 13129, 2016 | 154 | 2016 |
| Rotenone-induced impairment of mitochondrial electron transport chain confers a selective priming signal for NLRP3 inflammasome activation JH Won, S Park, S Hong, S Son, JW Yu Journal of Biological Chemistry 290 (45), 27425-27437, 2015 | 134 | 2015 |
| Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism HS Park, JW Yu, JH Cho, MS Kim, SH Huh, K Ryoo, EJ Choi Journal of Biological Chemistry 279 (9), 7584-7590, 2004 | 130 | 2004 |
| Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa JE Oh, BC Kim, DH Chang, M Kwon, SY Lee, D Kang, JY Kim, I Hwang, ... Proceedings of the National Academy of Sciences 113 (6), E762-E771, 2016 | 92 | 2016 |
| SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models OC Kwon, JJ Song, Y Yang, SH Kim, JY Kim, MJ Seok, I Hwang, JW Yu, ... EMBO molecular medicine 13 (4), e13076, 2021 | 82 | 2021 |
| Advanced glycation end products impair NLRP3 inflammasome–mediated innate immune responses in macrophages S Son, I Hwang, SH Han, JS Shin, OS Shin, JW Yu Journal of Biological Chemistry 292 (50), 20437-20448, 2017 | 68 | 2017 |
| Distinct features of brain-resident macrophages: microglia and non-parenchymal brain macrophages E Lee, JC Eo, C Lee, JW Yu Molecules and cells 44 (5), 281-291, 2021 | 67 | 2021 |
| Bacterial outer membrane vesicle-mediated cytosolic delivery of flagellin triggers host NLRC4 canonical inflammasome signaling J Yang, I Hwang, E Lee, SJ Shin, EJ Lee, JH Rhee, JW Yu Frontiers in immunology 11, 581165, 2020 | 58 | 2020 |
Emad AlnemriThomas Eakins Professor of Biochemistry and Molecular Biology, Thomas Jefferson UniversityEmail verificata su jefferson.edu