| Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints BJ Sánchez, C Zhang, A Nilsson, PJ Lahtvee, EJ Kerkhoven, J Nielsen Molecular systems biology 13 (8), 935, 2017 | 454 | 2017 |
| RAVEN 2.0: A versatile toolbox for metabolic network reconstruction and a case study on Streptomyces coelicolor H Wang, S Marcišauskas, BJ Sánchez, I Domenzain, D Hermansson, ... PLOS Computational Biology 14 (10), e1006541, 2018 | 357 | 2018 |
| An atlas of human metabolism JL Robinson, P Kocabaş, H Wang, PE Cholley, D Cook, A Nilsson, ... Science signaling 13 (624), eaaz1482, 2020 | 348 | 2020 |
| A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism H Lu, F Li, BJ Sánchez, Z Zhu, G Li, I Domenzain, S Marcišauskas, ... Nature communications 10 (1), 3586, 2019 | 342 | 2019 |
| Deep learning-based kcat prediction enables improved enzyme-constrained model reconstruction F Li, L Yuan, H Lu, G Li, Y Chen, MKM Engqvist, EJ Kerkhoven, J Nielsen Nature Catalysis 5 (8), 662-672, 2022 | 230 | 2022 |
| Barriers and opportunities in bio-based production of hydrocarbons YJ Zhou, EJ Kerkhoven, J Nielsen Nature Energy 3 (11), 925-935, 2018 | 192 | 2018 |
| Regulation of amino-acid metabolism controls flux to lipid accumulation in Yarrowia lipolytica EJ Kerkhoven, KR Pomraning, SE Baker, J Nielsen NPJ systems biology and applications 2, 16005, 2016 | 174 | 2016 |
| Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose DJ Creek, M Mazet, F Achcar, J Anderson, DH Kim, R Kamour, P Morand, ... PLoS pathogens 11 (3), e1004689, 2015 | 139 | 2015 |
| Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0 I Domenzain, B Sánchez, M Anton, EJ Kerkhoven, A Millán-Oropeza, ... Nature Communications 13, 2022 | 111 | 2022 |
| C/N ratio and carbon source-dependent lipid production profiling in Rhodotorula toruloides HJS Lopes, N Bonturi, EJ Kerkhoven, EA Miranda, PJ Lahtvee Applied microbiology and biotechnology 104 (6), 2639-2649, 2020 | 108 | 2020 |
| Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast C Malina, R Yu, J Björkeroth, EJ Kerkhoven, J Nielsen Proceedings of the National Academy of Sciences 118 (51), e2112836118, 2021 | 71 | 2021 |
| Proteome analysis of xylose metabolism in Rhodotorula toruloides during lipid production IA Tiukova, J Brandenburg, J Blomqvist, S Sampels, N Mikkelsen, ... Biotechnology for Biofuels 12 (1), 137, 2019 | 69 | 2019 |
| Advancing metabolic engineering of Yarrowia lipolytica using the CRISPR/Cas system TQ Shi, H Huang, EJ Kerkhoven, XJ Ji Applied microbiology and biotechnology 102, 9541-9548, 2018 | 67 | 2018 |
| A molecular genetic toolbox for Yarrowia lipolytica EL Bredeweg, KR Pomraning, Z Dai, J Nielsen, EJ Kerkhoven, SE Baker Biotechnology for biofuels 10 (1), 2, 2017 | 63 | 2017 |
| Genome‐scale model of Rhodotorula toruloides metabolism IA Tiukova, S Prigent, J Nielsen, M Sandgren, EJ Kerkhoven Biotechnology and bioengineering 116 (12), 3396-3408, 2019 | 62 | 2019 |
| Applications of computational modeling in metabolic engineering of yeast EJ Kerkhoven, PJ Lahtvee, J Nielsen FEMS Yeast Res 15 (1), 1-13, 2015 | 62 | 2015 |
| A domino effect in drug action: from metabolic assault towards parasite differentiation JR Haanstra, EJ Kerkhoven, A Van Tuijl, M Blits, M Wurst, R Van Nuland, ... Molecular microbiology 79 (1), 94-108, 2011 | 60 | 2011 |
| Genome‐scale metabolic model of Pichia pastoris with native and humanized glycosylation of recombinant proteins ZA Irani, EJ Kerkhoven, SA Shojaosadati, J Nielsen Biotechnology and bioengineering 113 (5), 961-969, 2016 | 58 | 2016 |
| Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei EJ Kerkhoven, F Achcar, VP Alibu, RJ Burchmore, IH Gilbert, M Trybiło, ... PLoS computational biology 9 (12), e1003371, 2013 | 57 | 2013 |
| SLIMEr: probing flexibility of lipid metabolism in yeast with an improved constraint-based modeling framework BJ Sánchez, F Li, EJ Kerkhoven, J Nielsen BMC Systems Biology 13 (1), 4, 2019 | 54 | 2019 |
Feiran Li 李斐然Tsinghua University, Chalmers Univeristy of TechnologyEmail verificata su sz.tsinghua.edu.cn