| Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin KN Nobles, K Xiao, S Ahn, AK Shukla, CM Lam, S Rajagopal, ... Science signaling 4 (185), ra51-ra51, 2011 | 731 | 2011 |
| Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors E Reiter, S Ahn, AK Shukla, RJ Lefkowitz Annual review of pharmacology and toxicology 52 (1), 179-197, 2012 | 707 | 2012 |
| GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling ARB Thomsen, B Plouffe, TJ Cahill, AK Shukla, JT Tarrasch, AM Dosey, ... Cell 166 (4), 907-919, 2016 | 584 | 2016 |
| Visualization of arrestin recruitment by a G-protein-coupled receptor AK Shukla, GH Westfield, K Xiao, RI Reis, LY Huang, P Tripathi-Shukla, ... Nature 512 (7513), 218-222, 2014 | 550 | 2014 |
| Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling AK Shukla, K Xiao, RJ Lefkowitz Trends in biochemical sciences 36 (9), 457-469, 2011 | 525 | 2011 |
| Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide AK Shukla, A Manglik, AC Kruse, K Xiao, RI Reis, WC Tseng, DP Staus, ... Nature 497 (7447), 137-141, 2013 | 497 | 2013 |
| Functional specialization of β-arrestin interactions revealed by proteomic analysis K Xiao, DB McClatchy, AK Shukla, Y Zhao, M Chen, SK Shenoy, ... Proceedings of the National Academy of Sciences 104 (29), 12011-12016, 2007 | 492 | 2007 |
| Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis TJ Cahill III, ARB Thomsen, JT Tarrasch, B Plouffe, AH Nguyen, F Yang, ... Proceedings of the National Academy of Sciences 114 (10), 2562-2567, 2017 | 397 | 2017 |
| Multiple ligand-specific conformations of the β2-adrenergic receptor AW Kahsai, K Xiao, S Rajagopal, S Ahn, AK Shukla, J Sun, TG Oas, ... Nature chemical biology 7 (10), 692-700, 2011 | 301 | 2011 |
| Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors AK Shukla, JD Violin, EJ Whalen, D Gesty-Palmer, SK Shenoy, ... Proceedings of the National Academy of Sciences 105 (29), 9988-9993, 2008 | 300 | 2008 |
| Methodological advances: the unsung heroes of the GPCR structural revolution E Ghosh, P Kumari, D Jaiman, AK Shukla Nature Reviews Molecular Cell Biology 16 (2), 69-81, 2015 | 265 | 2015 |
| β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice RW Walters, AK Shukla, JJ Kovacs, JD Violin, SM DeWire, CM Lam, ... The Journal of clinical investigation 119 (5), 1312-1321, 2009 | 261 | 2009 |
| Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor Y Lee, T Warne, R Nehmé, S Pandey, H Dwivedi-Agnihotri, M Chaturvedi, ... Nature 583 (7818), 862-866, 2020 | 243 | 2020 |
| Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR) K Xiao, J Sun, J Kim, S Rajagopal, B Zhai, J Villén, W Haas, JJ Kovacs, ... Proceedings of the National Academy of Sciences 107 (34), 15299-15304, 2010 | 234 | 2010 |
| β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2 SK Shenoy, AS Modi, AK Shukla, K Xiao, M Berthouze, S Ahn, ... Proceedings of the National Academy of Sciences 106 (16), 6650-6655, 2009 | 196 | 2009 |
| β-Arrestin–dependent activation of Ca2+/calmodulin kinase II after β1–adrenergic receptor stimulation S Mangmool, AK Shukla, HA Rockman Journal of Cell Biology 189 (3), 573-587, 2010 | 195 | 2010 |
| Functional competence of a partially engaged GPCR–β-arrestin complex P Kumari, A Srivastava, R Banerjee, E Ghosh, P Gupta, R Ranjan, X Chen, ... Nature communications 7 (1), 13416, 2016 | 171 | 2016 |
| Emerging functional divergence of β-arrestin isoforms in GPCR function A Srivastava, B Gupta, C Gupta, AK Shukla Trends in Endocrinology & Metabolism 26 (11), 628-642, 2015 | 166 | 2015 |
| Ubiquitination of β-arrestin links seven-transmembrane receptor endocytosis and ERK activation SK Shenoy, LS Barak, K Xiao, S Ahn, M Berthouze, AK Shukla, LM Luttrell, ... Journal of Biological Chemistry 282 (40), 29549-29562, 2007 | 163 | 2007 |
| Community guidelines for GPCR ligand bias: IUPHAR review 32 P Kolb, T Kenakin, SPH Alexander, M Bermudez, LM Bohn, CS Breinholt, ... British journal of pharmacology 179 (14), 3651-3674, 2022 | 157 | 2022 |