| Two distinct pools of B12 analogs reveal community interdependencies in the ocean KR Heal, W Qin, F Ribalet, AD Bertagnolli, W Coyote-Maestas, LR Hmelo, ... Proceedings of the National Academy of Sciences 114 (2), 364-369, 2017 | 190 | 2017 |
| Targeted insertional mutagenesis libraries for deep domain insertion profiling W Coyote-Maestas, D Nedrud, S Okorafor, Y He, D Schmidt Nucleic Acids Research, 2019 | 45 | 2019 |
| Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning W Coyote-Maestas, D Nedrud, Y He, D Schmidt Elife 11, e76903, 2022 | 42 | 2022 |
| DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology CB Macdonald, D Nedrud, PR Grimes, D Trinidad, JS Fraser, ... Genome biology 24 (1), 36, 2023 | 38* | 2023 |
| Domain insertion permissibility-guided engineering of allostery in ion channels W Coyote-Maestas, Y He, CL Myers, D Schmidt Nature communications 10 (1), 1-14, 2019 | 33 | 2019 |
| Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling W Coyote-Maestas, D Nedrud, A Suma, Y He, KA Matreyek, DM Fowler, ... Nature communications 12 (1), 7114, 2021 | 27 | 2021 |
| The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics SW Yee, CB Macdonald, D Mitrovic, X Zhou, ML Koleske, J Yang, ... Molecular cell 84 (10), 1932-1947. e10, 2024 | 20* | 2024 |
| Profiling the proximal proteome of the activated μ-opioid receptor BJ Polacco, BT Lobingier, EE Blythe, N Abreu, P Khare, MK Howard, ... Nature chemical biology 20 (9), 1133-1143, 2024 | 17* | 2024 |
| A large‐scale survey of pairwise epistasis reveals a mechanism for evolutionary expansion and specialization of PDZ domains D Nedrud, W Coyote‐Maestas, D Schmidt Proteins: Structure, Function, and Bioinformatics 89 (8), 899-914, 2021 | 17 | 2021 |
| Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain GO Estevam, EM Linossi, CB Macdonald, CA Espinoza, JM Michaud, ... Elife 12, RP91619, 2024 | 11 | 2024 |
| Molecular basis of proton sensing by G protein-coupled receptors MK Howard, N Hoppe, XP Huang, D Mitrovic, CB Billesbølle, ... Cell, 2025 | 7 | 2025 |
| Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage J Rao, R Xin, C Macdonald, MK Howard, GO Estevam, SW Yee, M Wang, ... Genome Biology 25 (1), 138, 2024 | 7 | 2024 |
| Using multiplexed functional data to reduce variant classification inequities in underrepresented populations M Dawood, S Fayer, S Pendyala, M Post, D Kalra, K Patterson, E Venner, ... Genome Medicine 16 (1), 1-16, 2024 | 3* | 2024 |
| Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning GO Estevam, E Linossi, J Rao, CB Macdonald, A Ravikumar, ... eLife 13, RP101882, 2025 | 1 | 2025 |
| DIMPLE library generation and assembly protocol C Macdonald, D Nedrud, PR Grimes, D Trinidad, C Shin, J Fraser, ... | 1 | 2023 |
| Rosace-AA: Enhancing Interpretation of Deep Mutational Scanning Data with Amino Acid Substitution and Position-Specific Insights J Rao, M Wang, MK Howard, C Macdonald, J Fraser, W Coyote-Maestas, ... bioRxiv, 2025.01. 09.632281, 2025 | | 2025 |
| A Suite of Foundation Models Captures the Contextual Interplay Between Codons M Naghipourfar, S Chen, MK Howard, CB Macdonald, A Saberi, T Hagen, ... bioRxiv, 2024 | | 2024 |
| Deep mutational scanning of EccD3 reveals the molecular basis of its essentiality in the mycobacterium ESX secretion system DD Trinidad, CB Macdonald, OS Rosenberg, JS Fraser, ... bioRxiv, 2024 | | 2024 |
| Deep mutational scanning reveals the impact of mutations on OCT1 function: Implications for precision medicine SW Yee, CB Macdonald, X Zhou, J Yang, D Trinidad, PR Grimes, ... PHARMACOGENETICS AND GENOMICS 33 (8), 183-184, 2023 | | 2023 |
| The Biophysical basis of protein domain compatibility D Schmidt, W Coyote-Maestas, D Nedrud, A Suma, Y He, KA Matreyek, ... PROTEIN SCIENCE 30, 73-74, 2021 | | 2021 |
