A single-cell transcriptomic atlas characterizes ageing tissues in the mouse Nature 583 (7817), 590-595, 2020 | 950 | 2020 |
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain J Marschallinger, T Iram, M Zardeneta, SE Lee, B Lehallier, MS Haney, ... Nature neuroscience 23 (2), 194-208, 2020 | 919 | 2020 |
Ageing hallmarks exhibit organ-specific temporal signatures N Schaum, B Lehallier, O Hahn, R Pálovics, S Hosseinzadeh, SE Lee, ... Nature 583 (7817), 596-602, 2020 | 482 | 2020 |
Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells A Abyzov, J Mariani, D Palejev, Y Zhang, MS Haney, L Tomasini, ... Nature 492 (7429), 438-442, 2012 | 450 | 2012 |
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens DW Morgens, M Wainberg, EA Boyle, O Ursu, CL Araya, CK Tsui, ... Nature communications 8 (1), 15178, 2017 | 390 | 2017 |
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains JV Pluvinage, MS Haney, BAH Smith, J Sun, T Iram, L Bonanno, L Li, ... Nature 568 (7751), 187-192, 2019 | 388 | 2019 |
CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity NJ Kramer, MS Haney, DW Morgens, A Jovičić, J Couthouis, A Li, J Ousey, ... Nature genetics 50 (4), 603-612, 2018 | 244 | 2018 |
Organ aging signatures in the plasma proteome track health and disease HSH Oh, J Rutledge, D Nachun, R Pálovics, O Abiose, P Moran-Losada, ... Nature 624 (7990), 164-172, 2023 | 213 | 2023 |
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens MS Haney, CJ Bohlen, DW Morgens, JA Ousey, AA Barkal, CK Tsui, ... Nature genetics 50 (12), 1716-1727, 2018 | 183 | 2018 |
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 T Iram, F Kern, A Kaur, S Myneni, AR Morningstar, H Shin, MA Garcia, ... Nature 605 (7910), 509-515, 2022 | 163 | 2022 |
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia MS Haney, R Pálovics, CN Munson, C Long, PK Johansson, O Yip, ... Nature 628 (8006), 154-161, 2024 | 138 | 2024 |
CRISPR-Cas9 screens identify the RNA helicase DDX3X as a repressor of C9ORF72 (GGGGCC) n repeat-associated non-AUG translation W Cheng, S Wang, Z Zhang, DW Morgens, LR Hayes, S Lee, B Portz, ... Neuron 104 (5), 885-898. e8, 2019 | 135 | 2019 |
Comprehensive, integrated, and phased whole-genome analysis of the primary ENCODE cell line K562 B Zhou, SS Ho, SU Greer, X Zhu, JM Bell, JG Arthur, N Spies, X Zhang, ... Genome research 29 (3), 472-484, 2019 | 116 | 2019 |
Molecular hallmarks of heterochronic parabiosis at single-cell resolution R Pálovics, A Keller, N Schaum, W Tan, T Fehlmann, M Borja, F Kern, ... Nature 603 (7900), 309-314, 2022 | 100 | 2022 |
Astrocyte‐to‐astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation J Li, RR Khankan, C Caneda, MI Godoy, MS Haney, MC Krawczyk, ... Glia 67 (8), 1571-1597, 2019 | 74 | 2019 |
Local and global chromatin interactions are altered by large genomic deletions associated with human brain development X Zhang, Y Zhang, X Zhu, C Purmann, MS Haney, T Ward, A Khechaduri, ... Nature communications 9 (1), 5356, 2018 | 49 | 2018 |
The role of glia in protein aggregation Q Li, MS Haney Neurobiology of Disease 143, 105015, 2020 | 43 | 2020 |
Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration RT Vest, CC Chou, H Zhang, MS Haney, L Li, NN Laqtom, B Chang, ... Proceedings of the National Academy of Sciences 119 (11), e2121609119, 2022 | 35 | 2022 |
Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72 N Chai, MS Haney, J Couthouis, DW Morgens, A Benjamin, K Wu, ... Brain Research 1728, 146601, 2020 | 30 | 2020 |
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C JV Pluvinage, J Sun, C Claes, RA Flynn, MS Haney, T Iram, X Meng, ... Science translational medicine 13 (622), eabg2919, 2021 | 29 | 2021 |